Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 / 5842 proteins

Scoring formula None

Sorted by Human E-value (ascending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4301 KP13_04491 putative hydrolase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0050118Catalysis of the reaction: H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + acetate. +14 total
No map 0.541 No Hit 0.0% —
4302 KP13_04492 hypothetical protein AlphaFold + ColabFold
1.-.-.-
GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
No map 0.643 No Hit 0.0% —
4303 KP13_04493 Cystine-binding periplasmic protein AlphaFold + ColabFold – – No map 0.259 No Hit 0.0% —
4304 KP13_04494 putative acyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.113 No Hit 0.0% —
4305 KP13_04495 Inner membrane amino-acid ABC transporter permease protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +36 total
No map 0.938 No Hit 0.0% —
4306 KP13_04497 Cystine-binding periplasmic protein AlphaFold + ColabFold – – No map 0.86 No Hit 0.0% —
4307 KP13_04498 putative GST-like protein AlphaFold + ColabFold – – No map 0.014 No Hit 0.0% —
4308 KP13_04499 Tautomerase pptA pptA AlphaFold + ColabFold
5.3.2.-
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0016862Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears. GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. +14 total
No map 0.541 No Hit 0.0% —
4309 KP13_04500 Sucrose porin AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034219The process in which a carbohydrate is transported across a membrane. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. +58 total
No map 0.839 No Hit 0.0% —
4310 KP13_04502 putative sugar hydrolase AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.617 No Hit 0.0% —
4311 KP13_04503 HTH-type transcriptional activator rhaS AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.176 No Hit 0.0% —
4312 KP13_04504 flavin reductase domain-containing protein AlphaFold + ColabFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016646Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.
No map 0.315 No Hit 0.0% —
4313 KP13_04506 putative ABC transporter substrate binding protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0046872Binding to a metal ion. GO:0030975Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. +25 total
No map 0.439 No Hit 0.0% —
4314 KP13_04507 Ferric transport system permease protein fbpB fbpB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.924 No Hit 0.0% —
4315 KP13_04509 Respiratory nitrate reductase 2 gamma chain narV AlphaFold + ColabFold
1.7.5.1
GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0008940Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +69 total
No map 0.999 No Hit 0.0% —
4316 KP13_04510 Respiratory nitrate reductase 2 delta chain narW AlphaFold + ColabFold –
GO:0051131The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. GO:0051082Binding to an unfolded protein. GO:0016530Binding to and delivering metal ions to a target protein. +14 total
No map 0.868 No Hit 0.0% —
4317 KP13_04511 Respiratory nitrate reductase 2 beta chain narY AlphaFold + ColabFold
1.7.5.1
GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0042126The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid. GO:0008940Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. +811 total
No map 0.613 No Hit 0.0% —
4318 KP13_04512 Respiratory nitrate reductase 2 alpha chain narZ AlphaFold + ColabFold
1.7.5.1
GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +811 total
No map 0.885 No Hit 0.0% —
4319 KP13_04513 Nitrite extrusion protein 2 narU AlphaFold + ColabFold –
GO:0015707The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015112Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +710 total
No map 0.794 No Hit 0.0% —
4320 KP13_04514 HTH-type transcriptional regulator betI AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.997 No Hit 0.0% —
4321 KP13_04515 Methyl viologen resistance protein smvA smvA AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.931 No Hit 0.0% —
4322 KP13_04516 Pca regulon regulatory protein pcaR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.514 No Hit 0.0% —
4323 KP13_04517 Muconate cycloisomerase 1 Experimental + ColabFold –
GO:0009063The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. GO:0030145Binding to a manganese ion (Mn). GO:0018850Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate. +14 total
No map 0.804 No Hit 0.0% —
4324 KP13_04518 Muconolactone Delta-isomerase catC AlphaFold + ColabFold
5.3.3.4
GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. GO:0016159Catalysis of the reaction: (S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate. GO:0042952A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates.
No map 0.022 No Hit 0.0% —
4325 KP13_04519 Catechol 1,2-dioxygenase AlphaFold + ColabFold
1.13.11.1
GO:0016702Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. GO:0009712The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. +69 total
No map 0.131 No Hit 0.0% —
Page of 234 · 5842 total proteins