Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4376 KP13_05263 putative HTH-type transcriptional regulator Experimental + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.331 No Hit 0.0% —
4377 KP13_04630 FeS cluster assembly protein sufD sufD AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
0.331 No Hit 0.0% —
4378 KP13_00892 hypothetical protein ColabFold – – 0.331 No Hit 0.0% —
4379 KP13_00746 Bacterioferritin bfr AlphaFold + ColabFold
1.16.3.1
GO:0008199Binding to a ferric iron ion, Fe(III). GO:0006879A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +47 total
0.331 No Hit 0.0% —
4380 KP13_00463 Alpha-galactosidase melA AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
0.331 No Hit 0.0% —
4381 KP13_03449 putative oligopeptide/dipeptide ABC transporter AlphaFold + ColabFold
7.4.2.10
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
0.33 Hit 52.6% 9.67e-06
4382 KP13_02734 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.33 No Hit 0.0% —
4383 KP13_00154 Sulfate-binding protein sbp AlphaFold + ColabFold –
GO:1901681Binding to a sulfur compound. GO:0140104Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. GO:1902358The directed movement of sulfate across a membrane. +14 total
0.33 No Hit 0.0% —
4384 KP13_32207 hypothetical protein AlphaFold + ColabFold – – 0.329 No Hit 0.0% —
4385 KP13_31929 putative transposase AlphaFold + ColabFold –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.329 No Hit 0.0% —
4386 KP13_04668 LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.329 No Hit 0.0% —
4387 KP13_03533 Ethanolamine utilization protein eutK eutK AlphaFold + ColabFold –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
0.329 No Hit 0.0% —
4388 KP13_02998 Molybdate-binding periplasmic protein modA Experimental + ColabFold –
GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0046872Binding to a metal ion. +25 total
0.329 No Hit 0.0% —
4389 KP13_02893 putative signal transduction response regulator ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.329 No Hit 0.0% —
4390 KP13_01632 Copper homeostasis protein cutC cutC AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005507Binding to a copper (Cu) ion.
0.329 Hit 50.9% 1.52e-48
4391 KP13_01502 putative transposase AlphaFold + ColabFold –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.329 No Hit 0.0% —
4392 KP13_05425 tetratricopeptide repeat-containing protein AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0008653The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. GO:0009898The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. +25 total
0.328 No Hit 0.0% —
4393 KP13_05257 Altronate oxidoreductase uxaB AlphaFold + ColabFold
1.1.1.58
GO:0009026Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + H+ + NADH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.328 No Hit 0.0% —
4394 KP13_03620 nucleoid-associated protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.328 No Hit 0.0% —
4395 KP13_01250 Inorganic pyrophosphatase ppa AlphaFold + ColabFold
3.6.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006796The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.328 No Hit 0.0% —
4396 KP13_03348 putative hydrolase AlphaFold + ColabFold –
GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
0.327 Hit 36.1% 1.51e-36
4397 KP13_01347 insertion element IS1 protein InsB insB ColabFold –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.327 No Hit 0.0% —
4398 KP13_00033 Phosphate import ATP-binding protein pstB ABC phosphate transporter pstB AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005315Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.327 Hit 33.9% 2.20e-23
4399 KP13_00012 Protein viaA viaA AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.327 No Hit 0.0% —
4400 KP13_04163 hypothetical protein AlphaFold + ColabFold – – 0.326 No Hit 0.0% —
Page of 234 · 5842 total proteins