Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4376 KP13_03061 putative ThiJ/PfpI family peptidase AlphaFold DB model + ColabFold model – – No map 0.201 0.4 No Hit 0.0% —
4377 KP13_02848 PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit dhaK dhaK AlphaFold DB model + ColabFold model
2.7.1.121
GO:0004371Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.201 0.727 Hit 48.1% 2.19e-36
4378 KP13_01222 hypothetical protein ColabFold model – – No map N/A 0.201 No Hit 0.0% —
4379 KP13_01184 GckR family protein AlphaFold DB model + ColabFold model –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0016835Catalysis of the breakage of a carbon-oxygen bond. GO:0046348The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. +36 total
No map 0.201 0.671 No Hit 0.0% —
4380 KP13_01152 putative membrane protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.200 0.842 No Hit 0.0% —
4381 KP13_00501 Outer membrane usher protein lpfC lpfC AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. +25 total
No map 0.200 0.873 No Hit 0.0% —
4382 KP13_32404 hypothetical protein ColabFold model – – No map N/A 0.199 No Hit 0.0% —
4383 KP13_05449 Phage shock protein B pspB AlphaFold DB model + ColabFold model –
GO:0009271A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map N/A 0.199 No Hit 0.0% —
4384 KP13_03748 putative response regulatory protein AlphaFold DB model + ColabFold model –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +14 total
No map 0.199 0.256 No Hit 0.0% —
4385 KP13_01794 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha accA AlphaFold DB model + ColabFold model
2.1.3.15
GO:0003989Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. GO:0009317A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. GO:0016874Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient. +47 total
No map 0.199 0.968 Hit 28.8% 3.73e-08
4386 KP13_03626 hypothetical protein AlphaFold DB model + ColabFold model –
GO:1990238Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.198 0.589 No Hit 0.0% —
4387 KP13_01622 Crossover junction endodeoxyribonuclease ruvC ruvC AlphaFold DB model + ColabFold model
3.1.21.10
GO:0004520Catalysis of the cleavage of ester linkages within deoxyribonucleic acid by creating internal breaks. GO:0003676Binding to a nucleic acid. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +69 total
No map 0.198 0.304 No Hit 0.0% —
4388 KP13_00886 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.198 0.671 No Hit 0.0% —
4389 KP13_32047 putative ABC transport system AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +14 total
No map 0.197 0.402 Hit 31.3% 4.86e-07
4390 KP13_31577 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.197 0.997 No Hit 0.0% —
4391 KP13_02073 hypothetical protein ColabFold model – – No map 0.197 0.889 No Hit 0.0% —
4392 KP13_01066 hypothetical protein ColabFold model – – No map N/A 0.197 No Hit 0.0% —
4393 KP13_31593 Zinc uptake regulation protein zur AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
No map 0.196 0.381 No Hit 0.0% —
4394 KP13_04148 Tellurium resistance protein terD terD AlphaFold DB model + ColabFold model –
GO:0046690Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus.
No map 0.196 0.07 No Hit 0.0% —
4395 KP13_01453 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.196 No Hit 0.0% —
4396 KP13_03944 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.195 No Hit 0.0% —
4397 KP13_02777 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.195 0.172 No Hit 0.0% —
4398 KP13_00936 GDP-mannose pyrophosphatase nudK nudK AlphaFold DB model + ColabFold model –
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0046872Binding to a metal ion. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.195 0.491 Hit 33.1% 2.04e-09
4399 KP13_00275 Cellulose synthase operon protein AlphaFold DB model + ColabFold model – – No map 0.195 0.42 No Hit 0.0% —
4400 KP13_00211 Glutaredoxin-3 grxC AlphaFold DB model + ColabFold model –
GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0015038Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. +25 total
No map N/A 0.195 Hit 34.1% 3.47e-10
Page of 234 · 5842 total proteins