Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4376 KP13_02339 Cobalt import ATP-binding protein CbiO cbiO AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
0.245 Hit 33.9% 4.16e-13
4377 KP13_01121 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA AlphaFold + ColabFold
2.5.1.7
GO:0008760Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. GO:0019277The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +69 total
0.245 No Hit 0.0% —
4378 KP13_03534 HTH-type transcriptional regulator eutR eutR AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.244 No Hit 0.0% —
4379 KP13_02742 hypothetical protein AlphaFold + ColabFold – – 0.244 No Hit 0.0% —
4380 KP13_01970 Non-specific ribonucleoside hydrolase rihC rihC AlphaFold + ColabFold
3.2.-.-
GO:0016798Catalysis of the hydrolysis of any glycosyl bond. GO:0016799Catalysis of the hydrolysis of any N-glycosyl bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
0.244 No Hit 0.0% —
4381 KP13_00078 GCN5-related N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.244 No Hit 0.0% —
4382 KP13_03284 Endonuclease 8 bifunctional protein nei AlphaFold + ColabFold
3.2.2.- 4.2.99.18
GO:0008270Binding to a zinc ion (Zn). GO:0003684Binding to damaged DNA. GO:0003906Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). +811 total
0.243 Hit 32.8% 3.75e-07
4383 KP13_02990 putative triphosphoribosyl-dephospho-CoA protein AlphaFold + ColabFold
2.4.2.52
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0046917Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. +14 total
0.243 No Hit 0.0% —
4384 KP13_00483 hypothetical protein AlphaFold + ColabFold – – 0.243 No Hit 0.0% —
4385 KP13_04980 hypothetical protein AlphaFold + ColabFold –
GO:0016846Catalysis of the elimination of hydrogen sulfide or substituted H2S. GO:0046872Binding to a metal ion.
0.242 Hit 42.9% 4.27e-09
4386 KP13_04968 Phenylacetic acid degradation protein paaB paaB Experimental + AlphaFold + ColabFold – – 0.242 No Hit 0.0% —
4387 KP13_03511 putative ABC transporter AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.242 Hit 35.7% 1.35e-19
4388 KP13_03379 Inositol-1-monophosphatase AlphaFold + ColabFold
3.1.3.25
GO:0008934Catalysis of the reaction: 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. GO:0046872Binding to a metal ion. GO:0006020The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. +25 total
0.242 Hit 35.0% 2.58e-06
4389 KP13_03049 putative glycoside hydrolase family 24 protein AlphaFold + ColabFold – – 0.242 No Hit 0.0% —
4390 KP13_02365 putative lipoprotein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.242 No Hit 0.0% —
4391 KP13_02177 Glycine cleavage system H protein gcvH AlphaFold + ColabFold –
GO:0005960A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. GO:0019464The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.242 Hit 47.8% 7.78e-24
4392 KP13_06286 hypothetical protein AlphaFold + ColabFold – – 0.241 No Hit 0.0% —
4393 KP13_05306 Cytochrome c-type biogenesis protein ccmE ccmE AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0017003The covalent linkage of heme and a protein. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +25 total
0.241 No Hit 0.0% —
4394 KP13_05189 Deoxyribose-phosphate aldolase AlphaFold + ColabFold
4.1.2.4
GO:0009264The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0004139Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. +36 total
0.241 Hit 34.8% 3.84e-07
4395 KP13_03700 2-dehydropantoate 2-reductase panE AlphaFold + ColabFold
1.1.1.169
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008677Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH. GO:0015940The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. +25 total
0.241 No Hit 0.0% —
4396 KP13_02241 Fimbria adhesin protein mrkD AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.241 No Hit 0.0% —
4397 KP13_00942 Ecotin eco AlphaFold + ColabFold –
GO:0004867Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.241 No Hit 0.0% —
4398 KP13_00748 30S ribosomal protein S10 rpsJ AlphaFold + ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +36 total
0.241 Hit 30.7% 1.59e-07
4399 KP13_31994 hypothetical protein AlphaFold + ColabFold – – 0.24 No Hit 0.0% —
4400 KP13_05182 AraC family transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.24 No Hit 0.0% —
Page of 208 · 5192 total proteins