Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4526 KP13_31611 Propanediol utilization protein pduB pduB AlphaFold + ColabFold –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy. GO:0005198The action of a molecule that contributes to the structural integrity of a complex.
0.215 No Hit 0.0% —
4527 KP13_03347 Sec-independent protein translocase protein tatE tatE AlphaFold + ColabFold –
GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043953The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex. +25 total
0.215 No Hit 0.0% —
4528 KP13_02366 hypothetical protein AlphaFold + ColabFold – – 0.215 No Hit 0.0% —
4529 KP13_04948 hypothetical protein AlphaFold + ColabFold – – 0.214 No Hit 0.0% —
4530 KP13_02216 MSF superfamily transporter AlphaFold + ColabFold – – 0.214 No Hit 0.0% —
4531 KP13_02201 putative lipoprotein AlphaFold + ColabFold –
GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.214 No Hit 0.0% —
4532 KP13_04029 Gp10 phage protein AlphaFold + ColabFold – – 0.213 No Hit 0.0% —
4533 KP13_00358 hypothetical protein AlphaFold + ColabFold – – 0.213 No Hit 0.0% —
4534 KP13_31855 GCN5-like N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.212 No Hit 0.0% —
4535 KP13_31743 putative serine protease AlphaFold + ColabFold
3.4.21.-
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
0.212 No Hit 0.0% —
4536 KP13_04633 Protein sufA sufA AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.212 Hit 37.7% 9.44e-25
4537 KP13_03485 WD40/YVTN repeat-like domain-containing protein AlphaFold + ColabFold –
GO:0005515Binding to a protein.
0.212 No Hit 0.0% —
4538 KP13_02724 hypothetical protein AlphaFold + ColabFold – – 0.212 No Hit 0.0% —
4539 KP13_02718 Rieske [2Fe-2S] iron-sulfur domain-containing protein AlphaFold + ColabFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
0.212 Hit 34.3% 5.67e-09
4540 KP13_02282 hypothetical protein AlphaFold + ColabFold – – 0.212 No Hit 0.0% —
4541 KP13_01787 peptidyl-tRNA hydrolase domain-containing protein AlphaFold + ColabFold
3.1.1.29
GO:0003747Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. GO:0006415The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
0.212 No Hit 0.0% —
4542 KP13_00143 Alpha-xylosidase AlphaFold + ColabFold
3.2.1.177
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +25 total
0.212 Hit 29.5% 4.82e-41
4543 KP13_05697 hypothetical protein AlphaFold + ColabFold – – 0.211 No Hit 0.0% —
4544 KP13_03235 Lipopolysaccharide export system protein lptC lptC AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015221Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. GO:0015920The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. +36 total
0.211 No Hit 0.0% —
4545 KP13_01065 hypothetical protein AlphaFold + ColabFold – – 0.211 No Hit 0.0% —
4546 KP13_01040 hypothetical protein AlphaFold + ColabFold
3.1.-.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0004521Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks. GO:0019843Binding to a ribosomal RNA. +14 total
0.211 No Hit 0.0% —
4547 KP13_32003 hypothetical protein AlphaFold + ColabFold – – 0.21 No Hit 0.0% —
4548 KP13_04719 Nitrate transport protein nasD nasD AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015112Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. GO:0015706The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
0.21 Hit 38.8% 9.15e-06
4549 KP13_03377 Cytosine deaminase AlphaFold + ColabFold –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0004131Catalysis of the reaction: cytosine + H2O = uracil + NH4+. GO:0035888Catalysis of the reaction: H+ + H2O + isoguanine = NH4+ + xanthine. +25 total
0.21 No Hit 0.0% —
4550 KP13_02758 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
0.21 No Hit 0.0% —
Page of 208 · 5192 total proteins