Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4576 KP13_05258 putative acyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.203 No Hit 0.0% —
4577 KP13_03481 Xylose isomerase-like, TIM barrel domain-containing protein AlphaFold + ColabFold – – 0.203 No Hit 0.0% —
4578 KP13_03266 Protein tolA tolA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0019534Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. GO:0043213The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain.
0.203 No Hit 0.0% —
4579 KP13_02488 Malate/L-lactate dehydrogenase domain-containing protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.203 No Hit 0.0% —
4580 KP13_01710 Diaminopimelate epimerase dapF AlphaFold + ColabFold
5.1.1.7
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0008837Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate. +14 total
0.203 No Hit 0.0% —
4581 KP13_03204 tRNA-dihydrouridine synthase C dusC AlphaFold + ColabFold
1.3.1.-
GO:0017150Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H. GO:0002943The process whereby a uridine in a transfer RNA is converted to dihydrouridine. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. +47 total
0.202 Hit 36.6% 4.71e-11
4582 KP13_02675 hypothetical protein AlphaFold + ColabFold – – 0.202 No Hit 0.0% —
4583 KP13_02120 hypothetical protein AlphaFold + ColabFold – – 0.202 No Hit 0.0% —
4584 KP13_01783 hypothetical protein AlphaFold + ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0089715Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine at position 37 = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine at position 37. GO:0032259The process in which a methyl group is covalently attached to a molecule. +14 total
0.202 Hit 40.4% 8.29e-19
4585 KP13_01582 Peptidoglycan synthase ftsI ftsI AlphaFold + ColabFold
3.4.16.4
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +811 total
0.202 No Hit 0.0% —
4586 KP13_00052 Phosphatase AlphaFold + ColabFold
3.1.3.23
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.202 No Hit 0.0% —
4587 KP13_31782 putative phospholipid ABC transporter-binding protein mlaD mlaD AlphaFold + ColabFold –
GO:0015914The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. GO:0005543Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. GO:0005548OBSOLETE. Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.
0.201 No Hit 0.0% —
4588 KP13_05436 Peptide transport system ATP-binding protein sapF sapF AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.201 Hit 33.3% 1.48e-06
4589 KP13_05336 putative siderophore transport system ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.201 Hit 34.2% 9.55e-07
4590 KP13_02392 7-carboxy-7-deazaguanine synthase-like protein AlphaFold + ColabFold
4.3.99.3
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +47 total
0.201 No Hit 0.0% —
4591 KP13_01664 hypothetical protein AlphaFold + ColabFold – – 0.201 No Hit 0.0% —
4592 KP13_01288 RutC family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
0.201 Hit 47.4% 4.98e-18
4593 KP13_04341 Hcp family type VI secretion system protein AlphaFold + ColabFold – – 0.2 No Hit 0.0% —
4594 KP13_00482 hypothetical protein AlphaFold + ColabFold – – 0.2 No Hit 0.0% —
4595 KP13_06651 hypothetical protein AlphaFold + ColabFold –
GO:0016311The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
0.199 No Hit 0.0% —
4596 KP13_05449 Phage shock protein B pspB AlphaFold + ColabFold –
GO:0009271A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.199 No Hit 0.0% —
4597 KP13_04097 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.199 No Hit 0.0% —
4598 KP13_03758 hypothetical protein AlphaFold + ColabFold – – 0.199 No Hit 0.0% —
4599 KP13_03212 D-galactose-binding periplasmic protein mglB AlphaFold + ColabFold –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0046872Binding to a metal ion. +14 total
0.199 No Hit 0.0% —
4600 KP13_00601 Alpha-galactosidase rafA AlphaFold + ColabFold
3.2.1.22
GO:0004557Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids. GO:0016052The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +14 total
0.199 No Hit 0.0% —
Page of 208 · 5192 total proteins