Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4701 KP13_00453 Protein phnJ phnJ AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0019700The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.
0.282 No Hit 0.0% —
4702 KP13_05232 HpxE hpxE AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. +14 total
0.281 No Hit 0.0% —
4703 KP13_00788 hypothetical protein AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.281 No Hit 0.0% —
4704 KP13_00496 hypothetical protein AlphaFold + ColabFold – – 0.281 No Hit 0.0% —
4705 KP13_31585 Mercuric transport protein periplasmic component merP AlphaFold + ColabFold –
GO:0045340Binding to a mercury ion (Hg2+). GO:0015097Enables the transfer of mercury (Hg2+) ions from one side of a membrane to the other. GO:0015694The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
0.28 Hit 32.8% 2.39e-07
4706 KP13_05414 Selenide, water dikinase selD AlphaFold + ColabFold
2.7.9.3
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016260The chemical reactions and pathways resulting in the formation of L-selenocysteine, an essential component of glutathione peroxidase and some other proteins. GO:0004756Catalysis of the reaction: ATP + H2O + hydrogen selenide = AMP + 3 H+ + phosphate + selenophosphorate. +25 total
0.28 Hit 56.8% 3.89e-08
4707 KP13_04702 UTP--glucose-1-phosphate uridylyltransferase galU AlphaFold + ColabFold
2.7.7.9
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0006011The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate. GO:0003983Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. +14 total
0.28 Hit 26.4% 2.91e-06
4708 KP13_04407 Mannonate dehydratase AlphaFold + ColabFold
4.2.1.8
GO:0008927Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. GO:0006064The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid. GO:0008198Binding to a ferrous iron ion, Fe(II). +25 total
0.28 No Hit 0.0% —
4709 KP13_04150 Tellurium resistance protein terF AlphaFold + ColabFold –
GO:0046690Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus.
0.28 No Hit 0.0% —
4710 KP13_03191 Putative osmoprotectant uptake system substrate-binding protein osmF osmF AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.28 No Hit 0.0% —
4711 KP13_02018 putative deoxyribonuclease AlphaFold + ColabFold –
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046872Binding to a metal ion.
0.28 Hit 34.6% 6.47e-14
4712 KP13_01889 Prepilin peptidase-dependent protein D ppdD AlphaFold + ColabFold –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.28 No Hit 0.0% —
4713 KP13_00603 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.28 No Hit 0.0% —
4714 KP13_00228 Selenocysteine-specific elongation factor selB AlphaFold + ColabFold –
GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +710 total
0.28 Hit 31.6% 4.80e-10
4715 KP13_00187 50S ribosomal protein L33 rpmG AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
0.28 Hit 44.4% 3.45e-07
4716 KP13_05003 hypothetical protein AlphaFold + ColabFold – – 0.279 No Hit 0.0% —
4717 KP13_04183 Hedgehog signaling domain-containing protein AlphaFold + ColabFold –
GO:0046872Binding to a metal ion. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +14 total
0.279 No Hit 0.0% —
4718 KP13_02793 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA cpdA AlphaFold + ColabFold
3.1.4.53
GO:0004115Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. GO:0004112Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +25 total
0.279 No Hit 0.0% —
4719 KP13_02346 Cysteine sulfinate desulfinase csdA AlphaFold + ColabFold
2.8.1.7
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. +25 total
0.279 Hit 30.1% 2.15e-07
4720 KP13_02194 Flavodoxin-2 fldB AlphaFold + ColabFold –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
0.279 No Hit 0.0% —
4721 KP13_01382 Transcriptional regulatory protein zraR zraR AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +36 total
0.279 No Hit 0.0% —
4722 KP13_32373 hypothetical protein ColabFold – – 0.278 No Hit 0.0% —
4723 KP13_04487 L-asparagine permease ansP AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.278 Hit 23.6% 3.76e-07
4724 KP13_03997 AFG1-family ATPase protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
0.278 Hit 50.0% 5.41e-12
4725 KP13_02668 hypothetical protein AlphaFold + ColabFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
0.278 No Hit 0.0% —
Page of 234 · 5842 total proteins