Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4701 KP13_03939 hypothetical protein ColabFold model – – No map N/A 0.138 No Hit 0.0% —
4702 KP13_01989 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0033194Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
No map 0.138 0.55 No Hit 0.0% —
4703 KP13_01268 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.138 0.799 No Hit 0.0% —
4704 KP13_00692 33 kDa chaperonin hslO AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051082Binding to an unfolded protein. GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +25 total
No map 0.138 0.294 No Hit 0.0% —
4705 KP13_00577 ATP-dependent protease hslV hslV AlphaFold DB model + ColabFold model
3.4.25.2
GO:0004298Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0051603OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. +36 total
No map 0.138 0.059 No Hit 0.0% —
4706 KP13_00226 glutathione S-transferase gst AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.138 0.673 Hit 30.3% 1.76e-08
4707 KP13_03300 putative transmembrane protein AlphaFold DB model + ColabFold model – – No map 0.137 0.792 No Hit 0.0% —
4708 KP13_03199 Multidrug resistance outer membrane protein mdtQ mdtQ AlphaFold DB model + ColabFold model –
GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.137 0.197 No Hit 0.0% —
4709 KP13_04859 Prophage lambda integrase intE ColabFold model –
GO:0008907Catalysis of the integration of one DNA segment into another. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.136 0.358 No Hit 0.0% —
4710 KP13_03991 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.136 0.082 No Hit 0.0% —
4711 KP13_03454 Phosphodiester alpha-GlcNAcase family protein AlphaFold DB model + ColabFold model – – No map 0.136 0.691 No Hit 0.0% —
4712 KP13_03424 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.136 0.627 No Hit 0.0% —
4713 KP13_02313 Propanediol utilization protein PduH pduH AlphaFold DB model + ColabFold model – – No map N/A 0.136 No Hit 0.0% —
4714 KP13_01153 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.136 No Hit 0.0% —
4715 KP13_00297 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.136 0.401 No Hit 0.0% —
4716 KP13_31634 Cysteine/O-acetylserine efflux protein eamB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.135 0.798 No Hit 0.0% —
4717 KP13_02636 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.135 No Hit 0.0% —
4718 KP13_01508 OmpA domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.135 0.75 No Hit 0.0% —
4719 KP13_06138 Thiol:disulfide interchange protein dsbA AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0015036Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. +14 total
No map 0.134 0.38 No Hit 0.0% —
4720 KP13_31860 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.133 No Hit 0.0% —
4721 KP13_05260 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.133 0.497 No Hit 0.0% —
4722 KP13_03393 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.133 No Hit 0.0% —
4723 KP13_01014 Histidine transport system permease protein hisM hisM AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +36 total
No map 0.133 0.704 No Hit 0.0% —
4724 KP13_04674 50S ribosomal protein L20 rplT AlphaFold DB model + ColabFold model –
GO:0019843Binding to a ribosomal RNA. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +14 total
No map N/A 0.132 Hit 40.4% 1.69e-07
4725 KP13_04664 Vitamin B12 transport periplasmic protein btuE btuE AlphaFold DB model + ColabFold model
1.11.1.24 1.11.1.9
GO:0004602Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0140824Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O. +14 total
No map 0.132 0.284 Hit 56.5% 3.33e-17
Page of 234 · 5842 total proteins