Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4651 KP13_06789 hypothetical protein ColabFold – – 0.289 No Hit 0.0% —
4652 KP13_02023 Peptide chain release factor 3 prfC AlphaFold + ColabFold –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0006415The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). +69 total
0.289 Hit 42.9% 6.08e-07
4653 KP13_01561 Septum site-determining protein minD minD AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0009898The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.289 Hit 26.8% 2.81e-09
4654 KP13_00542 hypothetical protein AlphaFold + ColabFold – – 0.289 No Hit 0.0% —
4655 KP13_04437 S-(hydroxymethyl)glutathione dehydrogenase AlphaFold + ColabFold
1.1.1.284
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006069OBSOLETE. An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. GO:0008270Binding to a zinc ion (Zn). +710 total
0.288 Hit 67.3% 4.95e-46
4656 KP13_04240 hypothetical protein AlphaFold + ColabFold – – 0.288 No Hit 0.0% —
4657 KP13_04220 Leucyl/phenylalanyl-tRNA--protein transferase aat AlphaFold + ColabFold –
GO:0030163The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. GO:0008914Catalysis of the reaction: L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H+ + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu). Can also transfer the leucyl residue on an N-terminal L-lysyl residue.
0.288 No Hit 0.0% —
4658 KP13_03868 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase fabA AlphaFold + ColabFold
4.2.1.59 5.3.3.14
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0008693OBSOLETE. Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O. +36 total
0.288 No Hit 0.0% —
4659 KP13_03211 Galactose/methyl galactoside import ATP-binding protein mglA mglA AlphaFold + ColabFold
7.5.2.11
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.288 Hit 36.1% 5.04e-07
4660 KP13_01855 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase folK AlphaFold + ColabFold
2.7.6.3
GO:0009396The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. GO:0003848Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.288 No Hit 0.0% —
4661 KP13_31872 putative transposase ColabFold – – 0.287 No Hit 0.0% —
4662 KP13_03967 Stability protein StbD AlphaFold + ColabFold – – 0.287 No Hit 0.0% —
4663 KP13_03236 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase kdsC Experimental + ColabFold
3.1.3.45
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0019143Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate. GO:0046872Binding to a metal ion. +25 total
0.287 Hit 32.3% 1.04e-18
4664 KP13_00714 Cytosine deaminase codA AlphaFold + ColabFold –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0004131Catalysis of the reaction: cytosine + H2O = uracil + NH4+. GO:0035888Catalysis of the reaction: H+ + H2O + isoguanine = NH4+ + xanthine. +25 total
0.287 No Hit 0.0% —
4665 KP13_00673 Glycerol-3-phosphate regulon repressor glpR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.287 No Hit 0.0% —
4666 KP13_08477 RNA polymerase sigma-32 factor rpoH AlphaFold + ColabFold –
GO:0006352The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place. GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.286 No Hit 0.0% —
4667 KP13_06735 conjugal transfer TrbG-like protein trbG AlphaFold + ColabFold – – 0.286 No Hit 0.0% —
4668 KP13_05083 HTH-type transcriptional regulator budR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
0.286 No Hit 0.0% —
4669 KP13_04046 Peptidase M15A ColabFold – – 0.286 No Hit 0.0% —
4670 KP13_03114 putative periplasmic protein AlphaFold + ColabFold – – 0.286 No Hit 0.0% —
4671 KP13_02614 2-isopropylmalate synthase AlphaFold + ColabFold
2.3.3.13
GO:0019752The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). GO:0003852Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+. GO:0009098The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid. +58 total
0.286 No Hit 0.0% —
4672 KP13_01298 GntR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.286 No Hit 0.0% —
4673 KP13_00062 hypothetical protein AlphaFold + ColabFold – – 0.286 No Hit 0.0% —
4674 KP13_05256 Putative GNAT family acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
0.285 Hit 27.7% 6.92e-06
4675 KP13_03426 Inhibitor of vertebrate lysozyme ivy AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0043086Any process that stops or reduces the activity of an enzyme.
0.285 No Hit 0.0% —
Page of 234 · 5842 total proteins