Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4651 KP13_00812 Signal peptidase I lepB AlphaFold DB model + ColabFold model
3.4.21.89
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006465OBSOLETE. The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +47 total
No map 0.150 0.733 No Hit 0.0% —
4652 KP13_06734 conjugal transfer TrbF-like protein trbF AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.149 0.578 No Hit 0.0% —
4653 KP13_03302 Protein seqA seqA AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0032297Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
No map 0.149 0.171 No Hit 0.0% —
4654 KP13_03075 Metallo-dependent phosphatases superfamily protein AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.149 0.553 No Hit 0.0% —
4655 KP13_02695 Acetolactate synthase isozyme 2 small subunit ilvM AlphaFold DB model + ColabFold model – – No map N/A 0.149 No Hit 0.0% —
4656 KP13_04355 hypothetical protein ColabFold model – – No map 0.148 0.602 No Hit 0.0% —
4657 KP13_01539 Proteasome subunit alpha/beta domain-containing protein AlphaFold DB model + ColabFold model –
GO:0005839A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. GO:0051603OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
No map 0.148 0.458 No Hit 0.0% —
4658 KP13_01528 High-affinity branched-chain amino acid transport system permease protein livH AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.148 0.85 No Hit 0.0% —
4659 KP13_00938 Nucleoid-associated protein ndpA ndpA AlphaFold DB model + ColabFold model –
GO:0009295The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.148 0.237 No Hit 0.0% —
4660 KP13_32199 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.147 No Hit 0.0% —
4661 KP13_31767 hypothetical protein ColabFold model – – No map N/A 0.147 No Hit 0.0% —
4662 KP13_02521 RNA polymerase sigma factor rpoS rpoS AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
No map 0.147 0.571 No Hit 0.0% —
4663 KP13_31783 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.146 No Hit 0.0% —
4664 KP13_07244 Bifunctional protein glmU glmU Experimental + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +58 total
No map 0.146 0.669 No Hit 0.0% —
4665 KP13_04987 Transcriptional regulator slyA AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.146 0.984 No Hit 0.0% —
4666 KP13_04846 hypothetical protein ColabFold model – – No map 0.146 0.89 No Hit 0.0% —
4667 KP13_02253 hypothetical protein ColabFold model – – No map 0.146 0.538 No Hit 0.0% —
4668 KP13_01493 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.146 0.149 No Hit 0.0% —
4669 KP13_00496 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.146 0.281 No Hit 0.0% —
4670 KP13_00005 D-ribose-binding periplasmic protein rbsB AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.146 0.307 No Hit 0.0% —
4671 KP13_15241 Prepilin peptidase-dependent protein B ppdB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
No map N/A 0.144 No Hit 0.0% —
4672 KP13_07162 Ribosomal RNA small subunit methyltransferase G rsmG AlphaFold DB model + ColabFold model
2.1.1.170
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008649Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. +25 total
No map 0.144 0.487 No Hit 0.0% —
4673 KP13_05598 hypothetical protein ColabFold model – – No map N/A 0.144 No Hit 0.0% —
4674 KP13_04226 Macrolide-specific efflux protein macA macA AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0019898The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. +69 total
No map N/A 0.144 No Hit 0.0% —
4675 KP13_02975 p-hydroxybenzoic acid efflux pump subunit aaeA aaeA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.144 0.086 No Hit 0.0% —
Page of 234 · 5842 total proteins