Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4751 KP13_04571 hypothetical protein Experimental + ColabFold model –
GO:0005254Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion.
No map 0.128 0.975 No Hit 0.0% —
4752 KP13_00871 Putative prophage CPS-53 integrase intS AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.128 0.083 No Hit 0.0% —
4753 KP13_00062 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.128 0.286 No Hit 0.0% —
4754 KP13_32387 hypothetical protein ColabFold model – – No map N/A 0.127 No Hit 0.0% —
4755 KP13_05427 translation initiation factor SUI1-like protein AlphaFold DB model + ColabFold model –
GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. GO:0006413The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. GO:0003729Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. +36 total
No map N/A 0.127 No Hit 0.0% —
4756 KP13_03871 Outer membrane protein A ompA AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. +36 total
No map 0.127 0.361 No Hit 0.0% —
4757 KP13_03598 putative ABC transporter ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.127 0.614 Hit 34.4% 1.71e-12
4758 KP13_03450 putative binding-protein-dependent transport system protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.127 0.738 No Hit 0.0% —
4759 KP13_00097 Putative 2-aminoethylphosphonate transport system permease protein phnU phnU AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0033223The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.127 0.736 No Hit 0.0% —
4760 KP13_31498 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut AlphaFold DB model + ColabFold model
3.6.1.23
GO:0000287Binding to a magnesium (Mg) ion. GO:0006226The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate). GO:0046081The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate. +14 total
No map 0.126 0.387 Hit 37.8% 1.74e-10
4761 KP13_04747 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.126 0.571 No Hit 0.0% —
4762 KP13_03522 putative ABC transporter permease AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.126 0.812 No Hit 0.0% —
4763 KP13_03008 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.126 0.579 No Hit 0.0% —
4764 KP13_00992 NADH-quinone oxidoreductase subunit B nuoB AlphaFold DB model + ColabFold model
7.1.1.-
GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. +710 total
No map 0.126 0.79 Hit 57.3% 5.01e-44
4765 KP13_00190 Lipopolysaccharide core biosynthesis glycosyltransferase waaE waaE AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.126 0.687 No Hit 0.0% —
4766 KP13_32056 F-type conjugative transfer system pilin assembly TraW AlphaFold DB model + ColabFold model – – No map 0.125 0.942 No Hit 0.0% —
4767 KP13_02540 Hemin import ATP-binding protein hmuV hmuV AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.125 0.3 Hit 34.1% 3.00e-17
4768 KP13_02036 LuxR family transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.125 0.258 No Hit 0.0% —
4769 KP13_31914 Fumarate hydratase class II fumC AlphaFold DB model + ColabFold model
4.2.1.2
GO:0006106The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. GO:0045239Any of the heteromeric enzymes that act in the TCA cycle. +69 total
No map 0.124 0.806 Hit 61.4% 6.20e-178
4770 KP13_03047 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.124 0.418 No Hit 0.0% —
4771 KP13_02448 Cystine-binding periplasmic protein AlphaFold DB model + ColabFold model – – No map 0.124 0.498 No Hit 0.0% —
4772 KP13_01792 Glyoxalase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion.
No map 0.124 0.238 No Hit 0.0% —
4773 KP13_00251 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map N/A 0.124 No Hit 0.0% —
4774 KP13_00030 Phosphate-binding protein pstS pstS AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0035435The process in which a phosphate is transported across a membrane. GO:0042301Binding to a phosphate ion.
No map 0.124 0.693 No Hit 0.0% —
4775 KP13_04851 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.123 0.559 No Hit 0.0% —
Page of 234 · 5842 total proteins