Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4751 KP13_05012 Maltose regulon regulatory protein malI malI AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.272 No Hit 0.0% —
4752 KP13_03215 Stringent starvation protein A sspA AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.272 Hit 32.2% 3.12e-09
4753 KP13_02590 Anaerobic nitric oxide reductase transcription regulator norR norR AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +69 total
0.272 No Hit 0.0% —
4754 KP13_01914 Protein mraZ mraZ AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.272 No Hit 0.0% —
4755 KP13_01598 Serine/threonine-protein phosphatase 1 AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.272 No Hit 0.0% —
4756 KP13_00316 Nickel-responsive regulator nikR AlphaFold + ColabFold –
GO:0016151Binding to a nickel (Ni) cation. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0010045Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus. +36 total
0.272 No Hit 0.0% —
4757 KP13_04317 C4-type zinc finger protein, DksA/TraR family AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:1900378Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.
0.271 No Hit 0.0% —
4758 KP13_03262 hypothetical protein AlphaFold + ColabFold – – 0.271 No Hit 0.0% —
4759 KP13_01963 hypothetical protein AlphaFold + ColabFold – – 0.271 No Hit 0.0% —
4760 KP13_01958 Protein apaG apaG AlphaFold + ColabFold –
GO:0070987The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
0.271 Hit 43.2% 2.11e-12
4761 KP13_01430 Tryptophanyl-tRNA synthetase AlphaFold + ColabFold – – 0.271 Hit 26.2% 8.32e-07
4762 KP13_00691 hypothetical protein AlphaFold + ColabFold – – 0.271 No Hit 0.0% —
4763 KP13_00303 putative iron-containing alcohol dehydrogenase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046872Binding to a metal ion. GO:0004022Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
0.271 Hit 27.5% 7.33e-15
4764 KP13_05136 Riboflavin synthase alpha chain ribE AlphaFold + ColabFold
2.5.1.9
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004746Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
0.27 No Hit 0.0% —
4765 KP13_04505 putative ABC transport system substrate-binding component AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015408Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.27 Hit 50.0% 1.02e-06
4766 KP13_03916 protein rutD rutD AlphaFold + ColabFold –
GO:0006212The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide.
0.27 Hit 28.4% 4.27e-06
4767 KP13_02708 Short-chain dehydrogenase/reductase family protein AlphaFold + ColabFold – – 0.27 Hit 39.1% 2.50e-07
4768 KP13_02490 Homoprotocatechuate degradative operon repressor hpcR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
0.27 No Hit 0.0% —
4769 KP13_02332 Cobalt-precorrin-3B C(17)-methyltransferase cbiH AlphaFold + ColabFold –
GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
0.27 No Hit 0.0% —
4770 KP13_02225 Protein fimG fimG AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.27 No Hit 0.0% —
4771 KP13_00418 Glutathione S-transferase 1 AlphaFold + ColabFold – – 0.27 Hit 25.3% 1.19e-06
4772 KP13_04858 Excisionase-like protein from lambdoid prophage 14 xisE AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.269 No Hit 0.0% —
4773 KP13_03226 Enhancing lycopene biosynthesis protein 2 elbB AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.269 Hit 54.8% 8.90e-31
4774 KP13_01489 hypothetical protein ColabFold – – 0.269 No Hit 0.0% —
4775 KP13_05491 hypothetical protein AlphaFold + ColabFold – – 0.268 No Hit 0.0% —
Page of 234 · 5842 total proteins