Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4676 KP13_01488 Sulphatase-modifying factor domain-containing protein AlphaFold DB model + ColabFold model –
GO:0120147Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O.
No map 0.144 0.428 Hit 35.3% 1.71e-06
4677 KP13_31991 pyridoxamine 5'-phosphate oxidase pdxH AlphaFold DB model + ColabFold model
1.4.3.5
GO:0016638Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0008615The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. GO:0004733Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + H2O2. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + H2O2. +14 total
No map 0.143 0.553 Hit 47.4% 2.30e-42
4678 KP13_05257 Altronate oxidoreductase uxaB AlphaFold DB model + ColabFold model
1.1.1.58
GO:0009026Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + H+ + NADH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No map 0.143 0.328 No Hit 0.0% —
4679 KP13_04685 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.143 0.388 No Hit 0.0% —
4680 KP13_04166 hypothetical protein ColabFold model – – No map N/A 0.143 No Hit 0.0% —
4681 KP13_01914 Protein mraZ mraZ AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.143 0.272 No Hit 0.0% —
4682 KP13_00872 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
No map N/A 0.143 No Hit 0.0% —
4683 KP13_31591 putative metalloprotease AlphaFold DB model + ColabFold model –
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
No map 0.142 0.359 No Hit 0.0% —
4684 KP13_03202 Beta-glucoside operon antiterminator arbG AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0003723Binding to an RNA molecule or a portion thereof.
No map 0.142 0.229 No Hit 0.0% —
4685 KP13_02037 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.142 0.738 No Hit 0.0% —
4686 KP13_06704 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.141 No Hit 0.0% —
4687 KP13_05252 Putative type VI secretion system effector, Hcp1 family ColabFold model – – No map 0.141 0.107 No Hit 0.0% —
4688 KP13_04371 Methionine import ATP-binding protein metN 1 AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.141 0.657 Hit 46.2% 5.12e-07
4689 KP13_04214 DNA translocase ftsK ftsK AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +47 total
No map 0.141 0.849 Hit 31.4% 9.04e-06
4690 KP13_01541 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.141 0.719 No Hit 0.0% —
4691 KP13_00744 hypothetical protein ColabFold model – – No map 0.141 0.785 No Hit 0.0% —
4692 KP13_00440 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.141 0.711 No Hit 0.0% —
4693 KP13_05082 Alpha-acetolactate decarboxylase budA AlphaFold DB model + ColabFold model
4.1.1.5
GO:0047605Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2. GO:0045151The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone.
No map 0.140 0.298 No Hit 0.0% —
4694 KP13_04574 morphology and auto-aggregation control protein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.140 0.907 No Hit 0.0% —
4695 KP13_04936 hypothetical protein ColabFold model – – No map 0.139 0.141 No Hit 0.0% —
4696 KP13_02802 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
No map N/A 0.139 No Hit 0.0% —
4697 KP13_00924 hypothetical protein ColabFold model – – No map 0.139 0.21 No Hit 0.0% —
4698 KP13_00817 Holo-[acyl-carrier-protein] synthase acpS AlphaFold DB model + ColabFold model
2.7.8.7
GO:0008897Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. GO:0000287Binding to a magnesium (Mg) ion. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +14 total
No map 0.139 0.047 No Hit 0.0% —
4699 KP13_31949 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.138 No Hit 0.0% —
4700 KP13_04915 hypothetical protein AlphaFold DB model + ColabFold model
4.2.2.29
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0008932Catalysis of the endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. +25 total
No map 0.138 0.631 No Hit 0.0% —
Page of 234 · 5842 total proteins