Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4676 KP13_02573 Formate hydrogenlyase subunit 2 hycB AlphaFold + ColabFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
0.285 No Hit 0.0% —
4677 KP13_02371 Serine transporter sdaC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0003333The process in which an amino acid is transported across a membrane. +36 total
0.285 No Hit 0.0% —
4678 KP13_32099 F-type conjugal transfer TraF-like protein AlphaFold + ColabFold – – 0.284 No Hit 0.0% —
4679 KP13_04664 Vitamin B12 transport periplasmic protein btuE btuE AlphaFold + ColabFold
1.11.1.24 1.11.1.9
GO:0004602Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0140824Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O. +14 total
0.284 Hit 56.5% 3.33e-17
4680 KP13_03665 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.284 No Hit 0.0% —
4681 KP13_01388 Streptomycin 3''-adenylyltransferase aadA AlphaFold + ColabFold
2.7.7.47
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0070566Catalysis of the transfer of an adenylyl group to an acceptor. +25 total
0.284 No Hit 0.0% —
4682 KP13_01330 Carbonic anhydrase 2 AlphaFold + ColabFold
4.2.1.1
GO:0004089Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. GO:0008270Binding to a zinc ion (Zn). GO:0015976A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. +25 total
0.284 No Hit 0.0% —
4683 KP13_00800 putative tRNA/rRNA methyltransferase AlphaFold + ColabFold –
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. +36 total
0.284 Hit 31.9% 1.17e-09
4684 KP13_00466 Plasmid stability protein stbB stbB AlphaFold + ColabFold – – 0.284 No Hit 0.0% —
4685 KP13_32021 hypothetical protein AlphaFold + ColabFold – – 0.283 No Hit 0.0% —
4686 KP13_05269 putative dihydrodipicolinate synthase AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0008840Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+. GO:0044281The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
0.283 Hit 28.8% 3.78e-18
4687 KP13_05022 Dihydrofolate reductase folM folM AlphaFold + ColabFold
1.5.1.3 1.5.1.50
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004146Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. GO:0006730The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
0.283 Hit 27.8% 5.70e-06
4688 KP13_04918 Acyl carrier protein acpP AlphaFold + ColabFold –
GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
0.283 Hit 51.9% 2.27e-13
4689 KP13_04882 putative ribose-5-phosphate isomerase B AlphaFold + ColabFold
5.3.1.6
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004751Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate.
0.283 No Hit 0.0% —
4690 KP13_04419 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.283 No Hit 0.0% —
4691 KP13_02842 Diol/glycerol dehydratase reactivating factor, small subunit Experimental + ColabFold –
GO:0046872Binding to a metal ion.
0.283 No Hit 0.0% —
4692 KP13_02508 hypothetical protein ColabFold – – 0.283 No Hit 0.0% —
4693 KP13_01888 Nicotinate-nucleotide pyrophosphorylase carboxylating nadC AlphaFold + ColabFold
2.4.2.19
GO:0004514Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). +25 total
0.283 Hit 38.6% 1.06e-13
4694 KP13_00524 epoxyqueosine reductase queG AlphaFold + ColabFold
1.17.99.6
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0008616The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in position 34 of tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. +58 total
0.283 No Hit 0.0% —
4695 KP13_32054 ATP-dependent DNA helicase TrhI trhI AlphaFold + ColabFold
5.6.2.4
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +47 total
0.282 No Hit 0.0% —
4696 KP13_12888 Mce domain-containing protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.282 No Hit 0.0% —
4697 KP13_05367 Short-chain dehydrogenase/reductase SDR protein AlphaFold + ColabFold –
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
0.282 Hit 26.4% 3.41e-06
4698 KP13_05149 Lactoylglutathione lyase gloA AlphaFold + ColabFold
4.4.1.5
GO:0004462Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. GO:0046872Binding to a metal ion. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.282 Hit 35.9% 1.03e-23
4699 KP13_02183 hypothetical protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016209Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
0.282 No Hit 0.0% —
4700 KP13_00838 Stationary phase-inducible protein CsiE csiE AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.282 No Hit 0.0% —
Page of 234 · 5842 total proteins