Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
451 KP13_03594 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK AlphaFold DB model + ColabFold model
6.3.4.18
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0046872Binding to a metal ion. +36 total
No map 0.953 0.56 No Hit 0.0% —
452 KP13_03546 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.953 0.953 No Hit 0.0% —
453 KP13_02862 Autoinducer 2 kinase lsrK lsrK AlphaFold DB model + ColabFold model
2.7.1.189
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0009372The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms. +25 total
No map 0.953 0.57 Hit 23.4% 5.69e-06
454 KP13_02806 Adenylate cyclase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0050355Catalysis of the reaction: H2O + inorganic triphosphate = diphosphate + phosphate. GO:0046872Binding to a metal ion.
No map 0.953 0.636 No Hit 0.0% —
455 KP13_02731 Glutathione synthetase gshB AlphaFold DB model + ColabFold model
6.3.2.3
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004363Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate. GO:0006750The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. +25 total
No map 0.953 0.974 No Hit 0.0% —
456 KP13_02380 putative glucarate transporter gudP AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map 0.953 0.908 Hit 31.5% 7.54e-07
457 KP13_02179 Glycine dehydrogenase gcvP AlphaFold DB model + ColabFold model
1.4.4.2
GO:0006546The chemical reactions and pathways resulting in the breakdown of glycine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006544The chemical reactions and pathways involving glycine, aminoethanoic acid. +69 total
No map 0.953 0.961 Hit 67.3% 2.72e-20
458 KP13_01878 Dihydrolipoyl dehydrogenase lpdA AlphaFold DB model + ColabFold model
1.8.1.4
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016668Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. +47 total
No map 0.953 0.981 Hit 52.8% 7.04e-16
459 KP13_01752 Multidrug resistance protein mdtM mdtM AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.953 0.716 No Hit 0.0% —
460 KP13_01162 Voltage-gated ClC-type chloride channel clcB clcB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005247Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. GO:0006821The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +47 total
No map 0.953 0.516 No Hit 0.0% —
461 KP13_00998 hypothetical protein AlphaFold DB model + ColabFold model
3.1.3.89
GO:0002953Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. +14 total
No map 0.953 0.233 No Hit 0.0% —
462 KP13_00494 60 kDa chaperonin groL AlphaFold DB model + ColabFold model
5.6.1.7
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140662Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. GO:0042026The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. +47 total
No map 0.953 0.209 Hit 75.0% 5.59e-08
463 KP13_32066 putative ramA repressor, RamR AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003723Binding to an RNA molecule or a portion thereof.
No map 0.952 0.826 No Hit 0.0% —
464 KP13_20430 extracellular solute-binding protein AlphaFold DB model + ColabFold model –
GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.952 0.794 No Hit 0.0% —
465 KP13_05199 Putative tartrate transporter AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.952 0.371 No Hit 0.0% —
466 KP13_05135 Multidrug resistance protein mdtK mdtK AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015297Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +14 total
No map 0.952 0.827 Hit 22.7% 7.92e-11
467 KP13_04877 Aldehyde dehydrogenase AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
No map 0.952 0.836 No Hit 0.0% —
468 KP13_04554 putative oxidoreductase AlphaFold DB model + ColabFold model –
GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
No map 0.952 0.847 Hit 41.2% 2.59e-07
469 KP13_04537 putative monooxygenase AlphaFold DB model + ColabFold model –
GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
No map 0.952 0.14 No Hit 0.0% —
470 KP13_04515 Methyl viologen resistance protein smvA smvA AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.952 0.931 No Hit 0.0% —
471 KP13_04293 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.952 0.868 No Hit 0.0% —
472 KP13_04210 Anaerobic dimethyl sulfoxide reductase chain A dmsA AlphaFold DB model + ColabFold model –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0009389Catalysis of the reaction: dimethyl sulfide + a menaquinone + H2O = dimethyl sulfoxide + a menaquinol. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +69 total
No map 0.952 0.922 No Hit 0.0% —
473 KP13_03791 putative glycosyltransferase family 2 AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.952 0.697 No Hit 0.0% —
474 KP13_03346 Lipoyl synthase lipA AlphaFold DB model + ColabFold model
2.8.1.8
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016992Catalysis of the reaction: [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
No map 0.952 0.819 Hit 45.1% 4.07e-48
475 KP13_03313 Glucosamine-6-phosphate deaminase AlphaFold DB model + ColabFold model
3.5.99.6
GO:0004342Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0006044The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. +58 total
No map 0.952 0.562 Hit 61.2% 9.23e-69
Page of 234 · 5842 total proteins