Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
476 KP13_03292 Inner membrane transporter AlphaFold DB model + ColabFold model –
GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. +710 total
No map 0.952 0.985 Hit 33.3% 6.04e-21
477 KP13_03220 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +14 total
No map 0.952 0.595 Hit 24.0% 3.38e-11
478 KP13_03130 Dihydropteroate synthase type-1 sulI AlphaFold DB model + ColabFold model
2.5.1.15
GO:0042558The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. GO:0004156Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. GO:0009396The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. +58 total
No map 0.952 0.923 No Hit 0.0% —
479 KP13_03124 Dihydropteroate synthase type-1 sul1 AlphaFold DB model + ColabFold model –
GO:0042558The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. GO:0004156Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. GO:0009396The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. +14 total
No map 0.952 0.923 No Hit 0.0% —
480 KP13_02258 Raffinose permease AlphaFold DB model + ColabFold model –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005351Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). +47 total
No map 0.952 0.436 No Hit 0.0% —
481 KP13_01892 GMP reductase guaC AlphaFold DB model + ColabFold model –
GO:0009117The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003920Catalysis of the reaction: IMP + NADP+ + NH4 = GMP + 2 H+ + NADPH. +25 total
No map 0.952 0.659 Hit 87.5% 2.28e-18
482 KP13_01610 Phosphogluconate dehydratase edd AlphaFold DB model + ColabFold model
4.2.1.12
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0009255A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
No map 0.952 0.725 No Hit 0.0% —
483 KP13_01466 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE Experimental + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016114The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. GO:0050515Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H+.
No map 0.952 0.628 No Hit 0.0% —
484 KP13_01230 D-serine/D-alanine/glycine transporter cycA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.952 0.892 Hit 25.2% 5.74e-06
485 KP13_01121 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA AlphaFold DB model + ColabFold model
2.5.1.7
GO:0008760Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. GO:0019277The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +69 total
No map 0.952 0.245 No Hit 0.0% —
486 KP13_00973 2-succinylbenzoate--CoA ligase menE AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008756Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate. GO:0009234The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2.
No map 0.952 0.121 Hit 31.0% 3.20e-12
487 KP13_00869 Inosine-5'-monophosphate dehydrogenase guaB AlphaFold DB model + ColabFold model
1.1.1.205
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003938Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
No map 0.952 0.501 Hit 50.4% 6.61e-27
488 KP13_00684 Ferrous iron transport protein B feoB Experimental + AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015093Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.952 0.993 No Hit 0.0% —
489 KP13_00559 Metal-binding protein AlphaFold DB model + ColabFold model –
GO:0008270Binding to a zinc ion (Zn).
No map 0.952 0.978 No Hit 0.0% —
490 KP13_00204 L-threonine 3-dehydrogenase tdh AlphaFold DB model + ColabFold model
1.1.1.103
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn). GO:0006567The chemical reactions and pathways resulting in the breakdown of L-threonine. +36 total
No map 0.952 0.45 Hit 32.4% 1.06e-08
491 KP13_32232 Formate dehydrogenase, nitrate-inducible, major subunit fdnG ColabFold model –
GO:0047111Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0008863Catalysis of the reaction: formate + NAD+ = CO2 + NADH. +1013 total
No map 0.951 0.928 No Hit 0.0% —
492 KP13_32163 maltose-inducible porin Maltoporin AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034219The process in which a carbohydrate is transported across a membrane. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
No map 0.951 0.632 No Hit 0.0% —
493 KP13_31939 Electron transport complex protein rnfC rnfC AlphaFold DB model + ColabFold model
7.-.-.-
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
No map 0.951 0.643 No Hit 0.0% —
494 KP13_20988 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.951 0.872 No Hit 0.0% —
495 KP13_05517 Nitronate monooxygenase AlphaFold DB model + ColabFold model –
GO:0018580Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite.
No map 0.951 0.663 No Hit 0.0% —
496 KP13_05404 carboxymuconolactone decarboxylase family protein AlphaFold DB model + ColabFold model –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
No map 0.951 0.739 No Hit 0.0% —
497 KP13_05375 Ferric enterobactin receptor pfeA AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). +14 total
No map 0.951 0.996 No Hit 0.0% —
498 KP13_05323 Major facilitator superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.951 0.964 No Hit 0.0% —
499 KP13_04708 putative transporter AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.951 0.727 No Hit 0.0% —
500 KP13_04445 Aryl-alcohol dehydrogenase AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.951 0.894 Hit 49.4% 5.33e-16
Page of 234 · 5842 total proteins