Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
426 KP13_31592 GCN5-related N-acetyltransferase AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.955 0.836 No Hit 0.0% —
427 KP13_04646 putative MFS-type transporter AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.955 0.695 No Hit 0.0% —
428 KP13_04359 putative oxidoreductase AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.955 0.524 Hit 36.7% 2.63e-09
429 KP13_03768 Histidinol dehydrogenase hisD AlphaFold DB model + ColabFold model
1.1.1.23
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0046872Binding to a metal ion. +58 total
No map 0.955 0.866 No Hit 0.0% —
430 KP13_03063 Short-chain dehydrogenases/reductases family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.955 0.974 Hit 39.8% 2.71e-11
431 KP13_01166 Thermostable carboxypeptidase 1 AlphaFold DB model + ColabFold model
3.4.17.19
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0004181Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0008270Binding to a zinc ion (Zn).
No map 0.955 0.102 No Hit 0.0% —
432 KP13_01104 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.955 0.846 No Hit 0.0% —
433 KP13_31765 reductase SDR family protein AlphaFold DB model + ColabFold model – – No map 0.954 0.809 Hit 35.2% 1.32e-10
434 KP13_05231 HpxD hpxD AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005506Binding to an iron (Fe) ion. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
No map 0.954 0.92 No Hit 0.0% —
435 KP13_04447 Ribosomal-protein-serine acetyltransferase rimL AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990189Catalysis of the reaction: acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-seryl-[protein]. +14 total
No map 0.954 0.209 No Hit 0.0% —
436 KP13_03218 Glutamate synthase [NADPH] small chain gltD AlphaFold DB model + ColabFold model
1.4.1.13
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. +36 total
No map 0.954 0.767 Hit 30.6% 4.10e-08
437 KP13_02822 putative O-sialoglycoprotein endopeptidase gcp AlphaFold DB model + ColabFold model
2.3.1.234
GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005506Binding to an iron (Fe) ion. +14 total
No map 0.954 0.606 Hit 42.4% 3.35e-14
438 KP13_02727 Galactose-proton symporter galP AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map 0.954 0.253 Hit 37.6% 1.09e-12
439 KP13_02505 Carbon starvation protein AlphaFold DB model + ColabFold model –
GO:0009267Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.954 0.996 No Hit 0.0% —
440 KP13_02469 Phosphoglycerol transferase I mdoB AlphaFold DB model + ColabFold model –
GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.
No map 0.954 0.986 No Hit 0.0% —
441 KP13_01335 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.954 0.852 No Hit 0.0% —
442 KP13_01092 Tryptophan-specific transport protein mtr AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015801The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0003333The process in which an amino acid is transported across a membrane. +14 total
No map 0.954 0.95 No Hit 0.0% —
443 KP13_00350 Malate synthase A aceB AlphaFold DB model + ColabFold model –
GO:0004474Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006097A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
No map 0.954 0.522 No Hit 0.0% —
444 KP13_31833 Isoleucyl-tRNA synthetase ileS AlphaFold DB model + ColabFold model
6.1.1.5
GO:0004822Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+. GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. +710 total
No map 0.953 0.944 Hit 36.7% 0.00e+00
445 KP13_06819 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.953 No Hit 0.0% —
446 KP13_05435 putative permease AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.953 0.855 No Hit 0.0% —
447 KP13_05395 Succinylglutamate desuccinylase astE AlphaFold DB model + ColabFold model –
GO:0008270Binding to a zinc ion (Zn). GO:0019545OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including succinate. GO:0009017Catalysis of the reaction: N-succinyl-L-glutamate + H2O = L-glutamate + succinate. +25 total
No map 0.953 0.678 No Hit 0.0% —
448 KP13_05056 Colicin I receptor cirA AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015344Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). GO:0044718The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore.
No map 0.953 0.943 No Hit 0.0% —
449 KP13_04740 putative oxidoreductase AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.953 0.162 Hit 39.8% 3.40e-06
450 KP13_04368 Alcohol dehydrogenase zinc-binding domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn).
No map 0.953 0.805 Hit 48.1% 7.41e-06
Page of 234 · 5842 total proteins