Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
501 KP13_03875 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.951 0.467 No Hit 0.0% —
502 KP13_03499 Arylsulfatase atsA AlphaFold DB model + ColabFold model –
GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. GO:0004065Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. GO:0046872Binding to a metal ion.
No map 0.951 0.784 Hit 41.4% 1.43e-10
503 KP13_00881 hypothetical protein ColabFold model – – No map N/A 0.951 No Hit 0.0% —
504 KP13_00602 HTH-type transcriptional regulator rafR rafR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.951 0.733 No Hit 0.0% —
505 KP13_00433 Acetyl-coenzyme A synthetase acs AlphaFold DB model + ColabFold model
6.2.1.1
GO:0019427OBSOLETE. The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate. GO:0016208Binding to AMP, adenosine monophosphate. GO:0003987Catalysis of the reaction: acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate. +47 total
No map 0.951 0.32 Hit 52.2% 1.61e-25
506 KP13_05477 hypothetical protein ColabFold model – – No map N/A 0.95 No Hit 0.0% —
507 KP13_03814 6-phospho-beta-glucosidase bglA AlphaFold DB model + ColabFold model
3.2.1.86
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.950 0.78 Hit 30.0% 7.30e-47
508 KP13_03169 FGGY carbohydrate kinase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +36 total
No map 0.950 0.726 Hit 49.4% 5.24e-51
509 KP13_02563 6-phospho-beta-glucosidase gmuD AlphaFold DB model + ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.950 0.983 Hit 32.8% 4.51e-28
510 KP13_02180 oxidoreductase AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
No map 0.950 0.77 Hit 39.0% 1.19e-10
511 KP13_01028 Erythronate-4-phosphate dehydrogenase pdxB AlphaFold DB model + ColabFold model
1.1.1.290
GO:0008615The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0033711Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H+ + NADH. +58 total
No map 0.950 0.439 Hit 31.2% 1.40e-11
512 KP13_00966 Inner membrane transport protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.950 0.797 Hit 24.1% 2.35e-11
513 KP13_00314 FAD-dependent oxidoreductase AlphaFold DB model + ColabFold model – – No map 0.950 0.999 No Hit 0.0% —
514 KP13_04929 Virulence factor mviN mviN AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015648Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +36 total
No map 0.949 0.789 No Hit 0.0% —
515 KP13_03164 Xylulose kinase AlphaFold DB model + ColabFold model
2.7.1.17
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +58 total
No map 0.949 0.367 Hit 23.9% 3.08e-26
516 KP13_03161 Mandelate racemase/muconate lactonizing enzyme family protein AlphaFold DB model + ColabFold model –
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0000287Binding to a magnesium (Mg) ion. GO:0016052The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.949 0.542 Hit 25.4% 1.75e-06
517 KP13_02368 Acyl-CoA dehydrogenase family protein AlphaFold DB model + ColabFold model –
GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0008470Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]. +14 total
No map 0.949 0.83 No Hit 0.0% —
518 KP13_02261 Putative ABC transporter substrate-binding protein AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
No map 0.949 0.363 No Hit 0.0% —
519 KP13_00516 Putative lysyl-tRNA synthetase poxA AlphaFold DB model + ColabFold model
6.3.2.-
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006430The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA. +710 total
No map 0.949 0.207 Hit 27.8% 6.40e-31
520 KP13_05552 putative carbohydrate kinase Experimental + ColabFold model –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006014The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. GO:0004747Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate.
No map 0.948 0.796 Hit 28.3% 1.24e-21
521 KP13_05355 Anthranilate synthase component 1 trpE AlphaFold DB model + ColabFold model
4.1.3.27
GO:0004049Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0046872Binding to a metal ion. +14 total
No map 0.948 0.663 No Hit 0.0% —
522 KP13_04995 Succinylglutamate desuccinylase AlphaFold DB model + ColabFold model
3.5.1.96
GO:0008270Binding to a zinc ion (Zn). GO:0019545OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including succinate. GO:0009017Catalysis of the reaction: N-succinyl-L-glutamate + H2O = L-glutamate + succinate. +25 total
No map 0.948 0.753 No Hit 0.0% —
523 KP13_04545 HTH-type DNA-binding domain-containing acetyltransferase AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.948 0.957 Hit 30.2% 2.10e-06
524 KP13_03568 Lysyl-tRNA synthetase AlphaFold DB model + ColabFold model
6.1.1.6
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003676Binding to a nucleic acid. +912 total
No map 0.948 0.755 Hit 51.2% 2.61e-17
525 KP13_03035 Phosphoethanolamine transferase eptA eptA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.
No map 0.948 0.941 No Hit 0.0% —
Page of 234 · 5842 total proteins