Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
26 KP13_02520 Lipoprotein nlpD nlpD AlphaFold + ColabFold –
GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.005 No Hit 0.0% —
27 KP13_04723 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.005 No Hit 0.0% —
28 KP13_05544 Cell envelope integrity inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0019534Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. GO:0043213The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain.
0.006 No Hit 0.0% —
29 KP13_06826 hypothetical protein AlphaFold + ColabFold – – 0.006 No Hit 0.0% —
30 KP13_00504 hypothetical protein ColabFold – – 0.007 No Hit 0.0% —
31 KP13_01737 Deoxyribonuclease tatD tatD AlphaFold + ColabFold
3.1.11.- 3.1.13.-
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.007 Hit 36.4% 3.42e-14
32 KP13_03389 putative oxidoreductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0046872Binding to a metal ion.
0.007 No Hit 0.0% —
33 KP13_05123 hypothetical protein AlphaFold + ColabFold – – 0.007 No Hit 0.0% —
34 KP13_02224 Protein fimH fimH Experimental + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.008 No Hit 0.0% —
35 KP13_05215 hypothetical protein AlphaFold + ColabFold – – 0.009 No Hit 0.0% —
36 KP13_32015 hypothetical protein ColabFold – – 0.01 No Hit 0.0% —
37 KP13_04783 hypothetical protein ColabFold – – 0.011 No Hit 0.0% —
38 KP13_01022 Protein dedD dedD AlphaFold + ColabFold –
GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0030428A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. GO:0032506A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). +25 total
0.012 No Hit 0.0% —
39 KP13_03803 putative glycosyltransferase family 2 in cps region AlphaFold + ColabFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
0.012 No Hit 0.0% —
40 KP13_01337 hypothetical protein AlphaFold + ColabFold –
GO:0006302The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0000731Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.
0.013 No Hit 0.0% —
41 KP13_00906 hypothetical protein AlphaFold + ColabFold – – 0.014 No Hit 0.0% —
42 KP13_04498 putative GST-like protein AlphaFold + ColabFold – – 0.014 No Hit 0.0% —
43 KP13_05328 hypothetical protein AlphaFold + ColabFold – – 0.014 No Hit 0.0% —
44 KP13_32212 Iron-binding protein iscA iscA AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.014 Hit 54.8% 7.79e-07
45 KP13_04157 hypothetical protein AlphaFold + ColabFold – – 0.016 No Hit 0.0% —
46 KP13_01359 50S ribosomal protein L7/L12 rplL AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +25 total
0.017 Hit 38.7% 7.16e-06
47 KP13_04814 hypothetical protein ColabFold – – 0.018 No Hit 0.0% —
48 KP13_05529 N-Acetyltransferase domain-containing protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.018 No Hit 0.0% —
49 KP13_00870 GMP synthase guaA AlphaFold + ColabFold –
GO:0006164The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0003922Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +25 total
0.019 Hit 36.5% 2.23e-93
50 KP13_03528 putative transposase InsK for insertion sequence element IS150 insK AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.019 No Hit 0.0% —
Page of 234 · 5842 total proteins