Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5001 KP13_02051 Glyoxalase/bleomycin resistance domain-containing protein AlphaFold + ColabFold – – 0.078 No Hit 0.0% —
5002 KP13_01473 hypothetical protein AlphaFold + ColabFold – – 0.078 No Hit 0.0% —
5003 KP13_04184 peptidoglycan binding-like protein AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +25 total
0.077 No Hit 0.0% —
5004 KP13_03003 hypothetical protein AlphaFold + ColabFold –
GO:0071468Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
0.077 No Hit 0.0% —
5005 KP13_02500 4-hydroxyphenylacetate catabolism regulatory protein AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.077 No Hit 0.0% —
5006 KP13_31766 cell division protein FtsY ftsY AlphaFold + ColabFold
3.6.5.4
GO:0006614The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. GO:0005525Binding to GTP, guanosine triphosphate. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +58 total
0.076 Hit 35.0% 1.48e-31
5007 KP13_03153 Transcriptional regulatory protein baeR baeR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
0.076 No Hit 0.0% —
5008 KP13_02303 putative propanediol utilization proteni AlphaFold + ColabFold –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
0.076 No Hit 0.0% —
5009 KP13_05156 HlyD-family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.075 No Hit 0.0% —
5010 KP13_04546 putative ABC transporter ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.075 Hit 50.0% 1.36e-06
5011 KP13_32243 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5012 KP13_32241 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5013 KP13_32147 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5014 KP13_06814 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5015 KP13_04583 Penicillin-binding protein 2 AlphaFold + ColabFold
3.4.16.4
GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. +69 total
0.074 No Hit 0.0% —
5016 KP13_04125 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5017 KP13_04120 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5018 KP13_03959 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5019 KP13_03730 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5020 KP13_02155 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5021 KP13_01585 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5022 KP13_01290 Aspartate carbamoyltransferase pyrB AlphaFold + ColabFold
2.1.3.2
GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. +47 total
0.074 Hit 42.3% 1.23e-74
5023 KP13_01069 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5024 KP13_05586 hypothetical protein AlphaFold + ColabFold – – 0.073 No Hit 0.0% —
5025 KP13_00114 hypothetical protein AlphaFold + ColabFold – – 0.073 No Hit 0.0% —
Page of 208 · 5192 total proteins