Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5401 KP13_31555 Mannitol operon repressor mtlR AlphaFold + ColabFold –
GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
0.452 No Hit 0.0% —
5402 KP13_31556 Electron transport protein hydN AlphaFold + ColabFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
0.445 No Hit 0.0% —
5403 KP13_31558 Protein bax bax AlphaFold + ColabFold –
GO:0004040Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH4+.
0.637 No Hit 0.0% —
5404 KP13_31559 Inner membrane protein AlphaFold + ColabFold
2.3.1.-
GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0016413Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. +14 total
0.688 No Hit 0.0% —
5405 KP13_31560 putative lipoprotein AlphaFold + ColabFold – – 0.639 No Hit 0.0% —
5406 KP13_31561 DNA-3-methyladenine glycosylase 1 tag AlphaFold + ColabFold
3.2.2.20
GO:0008725Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site. GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
0.248 No Hit 0.0% —
5407 KP13_31562 Phosphoethanolamine transferase eptB eptB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. +47 total
0.929 No Hit 0.0% —
5408 KP13_31563 Endoglucanase AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond.
0.469 No Hit 0.0% —
5409 KP13_31565 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase arnB AlphaFold + ColabFold
2.6.1.87
GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
0.56 No Hit 0.0% —
5410 KP13_31566 Anaerobic nitric oxide reductase flavorubredoxin norV AlphaFold + ColabFold –
GO:0016966Catalysis of the reaction: H2O + 2 ferricytochrome c + nitrous oxide = 2 H+ + 2 ferrocytochrome c + 2 nitric oxide. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0046872Binding to a metal ion. +47 total
0.519 No Hit 0.0% —
5411 KP13_31567 Glucitol/sorbitol permease IIC component srlA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
0.766 No Hit 0.0% —
5412 KP13_31568 Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE arnE AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:1901505Enables the transfer of carbohydrate derivative from one side of a membrane to the other. +36 total
0.74 No Hit 0.0% —
5413 KP13_31569 Protein dcrB dcrB AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.172 No Hit 0.0% —
5414 KP13_31572 Aminoglycoside N(6')-acetyltransferase aacA4 AlphaFold + ColabFold
2.3.1.82
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0047663Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H+. This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
0.042 No Hit 0.0% —
5415 KP13_31575 Plasmid segregation protein parM AlphaFold + ColabFold – – 0.695 No Hit 0.0% —
5416 KP13_31576 Multidrug resistance protein A AlphaFold + ColabFold –
GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.085 No Hit 0.0% —
5417 KP13_31577 hypothetical protein AlphaFold + ColabFold – – 0.997 No Hit 0.0% —
5418 KP13_31578 EAL domain-containing protein AlphaFold + ColabFold –
GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
0.619 No Hit 0.0% —
5419 KP13_31579 HTH-type transcriptional regulator merD merD AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.548 No Hit 0.0% —
5420 KP13_31581 Mercuric resistance protein merC merC AlphaFold + ColabFold –
GO:0015097Enables the transfer of mercury (Hg2+) ions from one side of a membrane to the other. GO:0015694The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.944 No Hit 0.0% —
5421 KP13_31584 Type-2 restriction enzyme EcoRII AlphaFold + ColabFold –
GO:0009307A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme. GO:0009036Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.771 No Hit 0.0% —
5422 KP13_31586 hypothetical protein ColabFold – – 0.188 No Hit 0.0% —
5423 KP13_31587 hypothetical protein AlphaFold + ColabFold – – 0.26 No Hit 0.0% —
5424 KP13_31588 putative alpha/beta-Hydrolases superfamily protein AlphaFold + ColabFold – – 0.165 No Hit 0.0% —
5425 KP13_31589 hypothetical protein ColabFold – – 0.166 No Hit 0.0% —
Page of 234 · 5842 total proteins