Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
526 KP13_00843 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ trmJ AlphaFold DB model + ColabFold model
2.1.1.200
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
No map 0.352 No Hit 0.0% —
527 KP13_00844 HTH-type transcriptional regulator iscR iscR AlphaFold DB model + ColabFold model –
GO:0003690Binding to double-stranded DNA. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
No map 0.096 No Hit 0.0% —
528 KP13_00851 Protein iscX iscX AlphaFold DB model + ColabFold model –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
No map 0.098 No Hit 0.0% —
529 KP13_00853 Protein sseB sseB AlphaFold DB model + ColabFold model – – No map 0.528 No Hit 0.0% —
530 KP13_00854 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.968 No Hit 0.0% —
531 KP13_00857 Penicillin-binding protein 1C pbpC AlphaFold DB model + ColabFold model
2.4.99.28
GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0008955Catalysis of the reaction: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+. +36 total
No map 0.635 No Hit 0.0% —
532 KP13_00859 Ribosomal RNA large subunit methyltransferase N rlmN AlphaFold DB model + ColabFold model
2.1.1.192
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0030488The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. GO:0070475The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. +1013 total
No map 0.583 No Hit 0.0% —
533 KP13_00860 Cytoskeleton protein rodZ rodZ AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008360Any process that modulates the surface configuration of a cell. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.457 No Hit 0.0% —
534 KP13_00861 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase ispG AlphaFold DB model + ColabFold model –
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0016114The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. GO:0005506Binding to an iron (Fe) ion. +25 total
No map 0.458 No Hit 0.0% —
535 KP13_00863 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0044877Binding to a macromolecular complex. GO:0005515Binding to a protein. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.395 No Hit 0.0% —
536 KP13_00864 Lipoprotein Experimental + ColabFold model –
GO:0005515Binding to a protein. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. +14 total
No map 0.438 No Hit 0.0% —
537 KP13_00866 putative oxidoreductase AlphaFold DB model + ColabFold model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
No map 0.221 No Hit 0.0% —
538 KP13_00867 putative oxidoreductase AlphaFold DB model + ColabFold model – – No map 0.604 No Hit 0.0% —
539 KP13_00868 Exodeoxyribonuclease 7 large subunit xseA AlphaFold DB model + ColabFold model
3.1.11.6
GO:0008855Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides. GO:0003676Binding to a nucleic acid. GO:0006308The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. +25 total
No map 0.29 No Hit 0.0% —
540 KP13_00871 Putative prophage CPS-53 integrase intS AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.083 No Hit 0.0% —
541 KP13_00872 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
No map 0.143 No Hit 0.0% —
542 KP13_00873 phage modification methylase MunI munIM AlphaFold DB model + ColabFold model –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
No map 0.506 No Hit 0.0% —
543 KP13_00874 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.6 No Hit 0.0% —
544 KP13_00875 hypothetical protein ColabFold model – – No map 0.879 No Hit 0.0% —
545 KP13_00876 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.338 No Hit 0.0% —
546 KP13_00877 hypothetical protein ColabFold model – – No map 0.482 No Hit 0.0% —
547 KP13_00878 Prophage CP4-57 regulatory protein AlphaFold DB model + ColabFold model – – No map 0.08 No Hit 0.0% —
548 KP13_00879 RecT-like protein AlphaFold DB model + ColabFold model –
GO:0006259Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.633 No Hit 0.0% —
549 KP13_00880 ReE-like protein AlphaFold DB model + ColabFold model – – No map 0.322 No Hit 0.0% —
550 KP13_00881 hypothetical protein ColabFold model – – No map 0.951 No Hit 0.0% —
Page of 234 · 5842 total proteins