Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5651 KP13_05054 GTP cyclohydrolase 1 folE AlphaFold DB model + ColabFold model
3.5.4.16
GO:0003934Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+. GO:0046654The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
No map 0.425 Hit 36.0% 2.62e-34
5652 KP13_03362 Aminotransferase AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
No map 0.165 Hit 34.2% 7.54e-35
5653 KP13_05547 Phosphotriesterase family protein AlphaFold DB model + ColabFold model –
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0008270Binding to a zinc ion (Zn). GO:0009056A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
No map 0.662 Hit 35.5% 3.60e-35
5654 KP13_04974 putative 3-hydroxybutyryl-CoA dehydrogenase paaH AlphaFold DB model + ColabFold model –
GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +14 total
No map 0.438 Hit 42.7% 2.11e-35
5655 KP13_03495 Histone deacetylase superfamily protein Experimental + ColabFold model
3.5.1.-
GO:0004407Removal of an acetyl group from a lysine residue in a histone. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. +14 total
No map 0.974 Hit 36.2% 2.04e-35
5656 KP13_03811 Phosphoribosylglycinamide formyltransferase purN AlphaFold DB model + ColabFold model
2.1.2.2
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0004644Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. +14 total
No map 0.601 Hit 44.0% 1.92e-35
5657 KP13_02992 Aldose 1-epimerase galM AlphaFold DB model + ColabFold model
5.1.3.3
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0006012The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. +710 total
No map 0.3 Hit 39.0% 1.20e-35
5658 KP13_31885 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA Experimental + ColabFold model
2.6.1.62
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. GO:0004015Catalysis of the reaction: (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = S-adenosyl-4-methylsulfanyl-2-oxobutanoate + (7R,8S)-7,8-diammoniononanoate. +36 total
No map 0.536 Hit 29.7% 9.59e-36
5659 KP13_02198 Peptide chain release factor 2 prfB AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003747Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. GO:0006415The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). +14 total
No map 0.048 Hit 49.2% 7.54e-36
5660 KP13_03022 Histidine ammonia-lyase hutH AlphaFold DB model + ColabFold model
4.3.1.3
GO:0016841Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004397Catalysis of the reaction: L-histidine = trans-urocanate + NH4+. +47 total
No map 0.438 Hit 50.3% 2.87e-36
5661 KP13_05264 L-lactate dehydrogenase 2 ldh2 AlphaFold DB model + ColabFold model
1.1.1.27
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0019752The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
No map 0.568 Hit 34.4% 2.64e-36
5662 KP13_00308 Oligopeptidase A prlC AlphaFold DB model + ColabFold model
3.4.24.70
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. +47 total
No map 0.84 Hit 41.4% 2.25e-36
5663 KP13_02848 PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit dhaK dhaK AlphaFold DB model + ColabFold model
2.7.1.121
GO:0004371Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.727 Hit 48.1% 2.19e-36
5664 KP13_02352 L-fucose mutarotase fucU AlphaFold DB model + ColabFold model
5.1.3.29
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0042354The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants. GO:0016854Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. +69 total
No map 0.415 Hit 47.2% 2.05e-36
5665 KP13_03348 putative hydrolase AlphaFold DB model + ColabFold model –
GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
No map 0.327 Hit 36.1% 1.51e-36
5666 KP13_01743 Xaa-Pro dipeptidase pepQ AlphaFold DB model + ColabFold model
3.4.13.9
GO:0016795Catalysis of the hydrolysis of a phosphoric triester. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004177Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. +47 total
No map 0.76 Hit 33.2% 9.09e-37
5667 KP13_02841 1,3-propanediol dehydrogenase dhaT Experimental + ColabFold model
1.1.1.202
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046872Binding to a metal ion. GO:0047516Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+. +14 total
No map 0.464 Hit 27.3% 8.49e-37
5668 KP13_04222 ATP-dependent Clp protease ATP-binding subunit clpA clpA AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0043335The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state. +47 total
No map 0.461 Hit 41.7% 6.27e-38
5669 KP13_01853 Glutamyl-Q tRNA(Asp) synthetase gluQ AlphaFold DB model + ColabFold model –
GO:0008270Binding to a zinc ion (Zn). GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +47 total
No map 0.147 Hit 36.9% 4.51e-38
5670 KP13_05360 putative hydroxypyruvate reductase ttuD AlphaFold DB model + ColabFold model –
GO:0008887Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.477 Hit 44.1% 1.01e-38
5671 KP13_03461 RomA protein romA AlphaFold DB model + ColabFold model –
GO:0008270Binding to a zinc ion (Zn). GO:0070290Catalysis of the reaction: an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) + H2O = an N-acylethanolamine (NAE) + a 1,2-diacyl-sn-glycero-3-phosphate + H+.
No map 0.408 Hit 31.4% 2.75e-39
5672 KP13_31803 glycine cleavage system aminomethyltransferase T gcvT AlphaFold DB model + ColabFold model –
GO:0006546The chemical reactions and pathways resulting in the breakdown of glycine. GO:0005515Binding to a protein. GO:0004047Catalysis of the reaction: N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4+.
No map 0.944 Hit 34.2% 1.99e-39
5673 KP13_00707 Ribulose-phosphate 3-epimerase rpe AlphaFold DB model + ColabFold model
5.1.3.1
GO:0004750Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016857Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. +47 total
No map 0.267 Hit 39.5% 1.96e-39
5674 KP13_03277 2-oxoglutarate dehydrogenase E1 component sucA AlphaFold DB model + ColabFold model
1.2.4.2
GO:0016624Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. GO:0004591Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2. GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. +36 total
No map 0.729 Hit 47.1% 1.94e-39
5675 KP13_05200 SMP-30/Gluconolaconase/LRE domain-containing protein AlphaFold DB model + ColabFold model –
GO:0005509Binding to a calcium ion (Ca2+). GO:0004341Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. GO:0019853The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
No map 0.546 Hit 32.3% 1.75e-39
Page of 234 · 5842 total proteins