Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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155 proteins Structure: Experimental

Scoring formula None

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
51 KP13_04591 putative epoxide hydrolase protein Experimental + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.786 Hit 33.3% 1.63e-11
52 KP13_01137 CinA family protein Experimental + ColabFold – – 0.781 No Hit 0.0% —
53 KP13_03769 Histidinol-phosphate aminotransferase hisC Experimental + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0004400Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. +36 total
0.775 Hit 30.7% 1.30e-08
54 KP13_01471 Peptidyl-tRNA hydrolase pth Experimental + ColabFold –
GO:0004045Catalysis of the reaction: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H+.
0.769 Hit 34.9% 3.14e-20
55 KP13_01911 Peptidoglycan synthase ftsI Experimental + ColabFold
3.4.16.4
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +811 total
0.756 No Hit 0.0% —
56 KP13_02795 ADP-ribose pyrophosphatase nudF Experimental + ColabFold
3.6.1.13
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0046872Binding to a metal ion. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +69 total
0.75 No Hit 0.0% —
57 KP13_01259 hypothetical protein Experimental + ColabFold –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
0.741 No Hit 0.0% —
58 KP13_31502 Gamma-glutamyltransferase Experimental + ColabFold – – 0.734 Hit 30.5% 2.52e-07
59 KP13_03709 hypothetical protein Experimental + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.73 No Hit 0.0% —
60 KP13_03381 Histidine acid phosphatase family protein Experimental + ColabFold
3.1.3.8
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0016158Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate. GO:0046872Binding to a metal ion. +14 total
0.725 No Hit 0.0% —
61 KP13_04769 AMP nucleosidase amn Experimental + ColabFold
3.2.2.4
GO:0044209The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis. GO:0009116The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
0.712 No Hit 0.0% —
62 KP13_00056 2-oxo-3-deoxygalactonate kinase dgoK Experimental + ColabFold –
GO:0008671Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+. GO:0034194The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid.
0.709 No Hit 0.0% —
63 KP13_03173 Hydroxyethylthiazole kinase thiM Experimental + ColabFold –
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0000287Binding to a magnesium (Mg) ion. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.708 No Hit 0.0% —
64 KP13_01272 putative aldolase Experimental + ColabFold – – 0.706 No Hit 0.0% —
65 KP13_02356 L-fuculose phosphate aldolase fucA Experimental + ColabFold –
GO:0008738Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate. GO:0008270Binding to a zinc ion (Zn). GO:0006004The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose.
0.703 No Hit 0.0% —
66 KP13_04201 Phosphoserine aminotransferase serC Experimental + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006564The chemical reactions and pathways resulting in the formation of L-serine. GO:0004648Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.
0.699 Hit 47.8% 1.14e-118
67 KP13_02839 glycerol dehydratase large subunit dhaB Experimental + ColabFold
4.2.1.30
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0031419Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +14 total
0.699 No Hit 0.0% —
68 KP13_02837 glycerol dehydratase small subunit dhaE Experimental + ColabFold
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
0.695 No Hit 0.0% —
69 KP13_19569 Betaine aldehyde dehydrogenase betB Experimental + ColabFold
1.2.1.8
GO:0019285The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline. GO:0046872Binding to a metal ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +25 total
0.692 Hit 53.1% 3.72e-08
70 KP13_31534 6-phosphogluconate dehydrogenase, decarboxylating gnd Experimental + ColabFold
1.1.1.44
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0004616Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. +25 total
0.687 Hit 58.2% 4.94e-76
71 KP13_05266 4-hydroxythreonine-4-phosphate dehydrogenase 2 pdxA2 Experimental + ColabFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0046872Binding to a metal ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.682 No Hit 0.0% —
72 KP13_00069 6-phospho-alpha-glucosidase aglB Experimental + ColabFold
3.2.1.122
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +47 total
0.681 No Hit 0.0% —
73 KP13_02775 Cystathionine beta-lyase metC Experimental + ColabFold
4.4.1.13
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0004121OBSOLETE. Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. +69 total
0.673 Hit 31.9% 4.89e-47
74 KP13_02816 Urease subunit alpha ureC Experimental + ColabFold
3.5.1.5
GO:0016151Binding to a nickel (Ni) cation. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0009039Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+. +47 total
0.672 No Hit 0.0% —
75 KP13_07244 Bifunctional protein glmU glmU Experimental + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +58 total
0.669 No Hit 0.0% —
Page of 7 · 155 total proteins