Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
826 KP13_05241 putative D-methionine transport system permease protein metI AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.871 No Hit 0.0% —
827 KP13_02619 putative inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1903785The directed movement of L-valine across a membrane.
0.871 No Hit 0.0% —
828 KP13_02599 putative ABC transporter protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.871 No Hit 0.0% —
829 KP13_00597 putative rhamnose ABC transporter, permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.871 No Hit 0.0% —
830 KP13_31931 hypothetical protein AlphaFold + ColabFold – – 0.87 No Hit 0.0% —
831 KP13_05118 putative chloramphenicol acetyltransferase AlphaFold + ColabFold –
GO:0008811Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA.
0.87 No Hit 0.0% —
832 KP13_04941 hypothetical protein AlphaFold + ColabFold
1.14.-.-
GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
0.87 Hit 31.2% 4.43e-31
833 KP13_03261 Quinolinate synthase A nadA AlphaFold + ColabFold
2.5.1.72
GO:0008987Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +47 total
0.87 No Hit 0.0% —
834 KP13_03158 putative ABC transporter permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.87 No Hit 0.0% —
835 KP13_01318 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase iolD AlphaFold + ColabFold –
GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. GO:0016823Catalysis of the hydrolysis of any carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group. GO:0000287Binding to a magnesium (Mg) ion. +25 total
0.87 Hit 31.8% 1.18e-07
836 KP13_01048 Inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.87 No Hit 0.0% —
837 KP13_00837 putative 3-phenylpropionic acid transporter hcaT AlphaFold + ColabFold – – 0.87 No Hit 0.0% —
838 KP13_00198 O-antigen ligase protein in waa region waaL AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.87 No Hit 0.0% —
839 KP13_04428 Adenosine deaminase add AlphaFold + ColabFold
3.5.4.4
GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R). GO:0004000Catalysis of the reaction: adenosine + H2O = inosine + NH4+. GO:0009168The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. +710 total
0.869 Hit 43.9% 5.36e-06
840 KP13_03710 Sensor kinase cusS cusS AlphaFold + ColabFold
2.7.13.3
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0004673Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. +69 total
0.869 No Hit 0.0% —
841 KP13_03628 HTH-type transcriptional regulator AcrR acrR AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +25 total
0.869 No Hit 0.0% —
842 KP13_03225 Aerobic respiration control sensor protein arcB arcB AlphaFold + ColabFold
2.7.13.3
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). +811 total
0.869 No Hit 0.0% —
843 KP13_00141 hypothetical protein AlphaFold + ColabFold – – 0.869 No Hit 0.0% —
844 KP13_31619 Glutamate synthase [NADPH] large chain gltB AlphaFold + ColabFold
1.4.1.13
GO:0006537OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. GO:0016638Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +69 total
0.868 No Hit 0.0% —
845 KP13_04510 Respiratory nitrate reductase 2 delta chain narW AlphaFold + ColabFold –
GO:0051131The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. GO:0051082Binding to an unfolded protein. GO:0016530Binding to and delivering metal ions to a target protein. +14 total
0.868 No Hit 0.0% —
846 KP13_04293 hypothetical protein AlphaFold + ColabFold – – 0.868 No Hit 0.0% —
847 KP13_04133 TerY type protein AlphaFold + ColabFold – – 0.868 No Hit 0.0% —
848 KP13_04048 Phage DNA adenine methylase AlphaFold + ColabFold
2.1.1.-
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0006306OBSOLETE. The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. GO:0003676Binding to a nucleic acid. +36 total
0.868 No Hit 0.0% —
849 KP13_02994 Galactose-1-phosphate uridylyltransferase galT AlphaFold + ColabFold
2.7.7.12
GO:0006012The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. GO:0008270Binding to a zinc ion (Zn). GO:0033499The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose. +25 total
0.868 Hit 58.6% 4.52e-18
850 KP13_02827 G/U mismatch-specific DNA glycosylase mug AlphaFold + ColabFold
3.2.2.28
GO:0006285The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired. GO:0000700Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.868 Hit 47.5% 6.66e-07
Page of 208 · 5192 total proteins