Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
76 KP13_01364 PEP-sugar phosphotransferase enzyme IIB subunit AlphaFold + ColabFold
2.7.1.205 2.7.1.- 2.7.1.191 +14 total
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.03 No Hit 0.0% —
77 KP13_01410 hypothetical protein AlphaFold + ColabFold – – 0.03 No Hit 0.0% —
78 KP13_01424 hypothetical protein AlphaFold + ColabFold – – 0.03 No Hit 0.0% —
79 KP13_04770 Signal transduction protein pmrD pmrD AlphaFold + ColabFold – – 0.03 No Hit 0.0% —
80 KP13_02226 Protein fimF fimF AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.031 No Hit 0.0% —
81 KP13_00829 Flavohemoprotein hmp AlphaFold + ColabFold
1.14.12.17
GO:0008941Catalysis of the reaction: 2 NO + 2 O2 + NAD(P)H + H+ = 2 nitrate + NAD(P)+. GO:0051409Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +811 total
0.032 Hit 26.0% 1.34e-08
82 KP13_01397 hypothetical protein AlphaFold + ColabFold – – 0.032 No Hit 0.0% —
83 KP13_04607 4-hydroxy-2-oxovalerate aldolase mhpE AlphaFold + ColabFold
4.1.3.39
GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. GO:0016833Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
0.032 Hit 26.5% 5.31e-07
84 KP13_01702 hypothetical protein AlphaFold + ColabFold – – 0.033 No Hit 0.0% —
85 KP13_00572 hypothetical protein AlphaFold + ColabFold – – 0.034 No Hit 0.0% —
86 KP13_03431 GCN5-related N-acetyltransferase (GNAT) domain-containing protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.034 No Hit 0.0% —
87 KP13_03548 Pyridoxine kinase pdxK AlphaFold + ColabFold
2.7.1.35
GO:0009443Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis. GO:0008478Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.034 Hit 29.5% 5.80e-22
88 KP13_00430 putative adhesin AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.035 No Hit 0.0% —
89 KP13_00486 Divalent-cation tolerance protein cutA cutA AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005507Binding to a copper (Cu) ion. GO:0010038Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
0.035 Hit 40.5% 8.45e-16
90 KP13_00900 hypothetical protein AlphaFold + ColabFold – – 0.035 No Hit 0.0% —
91 KP13_01062 hypothetical protein AlphaFold + ColabFold – – 0.035 No Hit 0.0% —
92 KP13_05324 putative glyoxalase family protein AlphaFold + ColabFold –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
0.036 No Hit 0.0% —
93 KP13_02230 Fimbrial subunit type 1 fim AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.037 No Hit 0.0% —
94 KP13_02456 Type 1 fimbrial protein subunit AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.037 No Hit 0.0% —
95 KP13_04560 hypothetical protein AlphaFold + ColabFold – – 0.037 No Hit 0.0% —
96 KP13_00014 Regulatory protein asnC asnC AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.038 No Hit 0.0% —
97 KP13_01380 Zinc resistance-associated protein zraP AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.038 No Hit 0.0% —
98 KP13_01714 DNA helicase II uvrD AlphaFold + ColabFold
5.6.2.4
GO:0006268OBSOLETE. The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +1013 total
0.038 No Hit 0.0% —
99 KP13_03115 putative periplasmic protein AlphaFold + ColabFold – – 0.038 No Hit 0.0% —
100 KP13_04684 Protein tonB tonB AlphaFold + ColabFold –
GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
0.038 No Hit 0.0% —
Page of 234 · 5842 total proteins