Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
976 KP13_31547 Multidrug resistance protein D emrD AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.844 No Hit 0.0% —
977 KP13_03150 Multidrug resistance protein mdtC mdtC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.844 No Hit 0.0% —
978 KP13_02415 Bifunctional T-protein tyrA AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004665Catalysis of the reaction: NADP+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADPH. GO:0006571The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. +47 total
0.844 No Hit 0.0% —
979 KP13_01703 Protein hemY hemY AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515Binding to a protein. GO:0042168The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. +25 total
0.844 No Hit 0.0% —
980 KP13_03609 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase AlphaFold + ColabFold
4.2.-.-
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. +14 total
0.843 No Hit 0.0% —
981 KP13_02809 Undecaprenyl-diphosphatase uppP AlphaFold + ColabFold
3.6.1.27
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016311The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. GO:0050380Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate. +58 total
0.843 No Hit 0.0% —
982 KP13_02434 START-like domain-containing protein AlphaFold + ColabFold –
GO:0045333The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. GO:0048039Binding to ubiquinone, a quinone derivative with a tail of isoprene units.
0.843 Hit 28.1% 4.71e-12
983 KP13_01741 3-ketoacyl-CoA thiolase fadA AlphaFold + ColabFold
2.3.1.16
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016042The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
0.843 Hit 45.2% 5.85e-71
984 KP13_01554 Na(+)/H(+) antiporter nhaB nhaB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015385Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). +14 total
0.843 No Hit 0.0% —
985 KP13_01532 Threonine/serine transporter tdcC tdcC AlphaFold + ColabFold –
GO:0032329The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0003333The process in which an amino acid is transported across a membrane. GO:0022889OBSOLETE. Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid. +811 total
0.843 No Hit 0.0% —
986 KP13_00399 Ferrienterobactin receptor fepA AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). +58 total
0.843 No Hit 0.0% —
987 KP13_00170 methylated-DNA/protein-cysteine methyltransferase AlphaFold + ColabFold
2.1.1.63
GO:0008270Binding to a zinc ion (Zn). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +710 total
0.843 Hit 31.3% 2.39e-16
988 KP13_04539 putative D,D-dipeptide transport system permease protein ddpC ddpC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.842 No Hit 0.0% —
989 KP13_04127 hypothetical protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.842 No Hit 0.0% —
990 KP13_01681 putative inner membrane protein AlphaFold + ColabFold – – 0.842 No Hit 0.0% —
991 KP13_01673 hypothetical protein AlphaFold + ColabFold – – 0.842 No Hit 0.0% —
992 KP13_01152 putative membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.842 No Hit 0.0% —
993 KP13_05502 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.841 No Hit 0.0% —
994 KP13_04313 putative mscS family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. +14 total
0.841 No Hit 0.0% —
995 KP13_02717 hypothetical protein AlphaFold + ColabFold – – 0.841 No Hit 0.0% —
996 KP13_01360 DNA-directed RNA polymerase subunit beta rpoB Experimental + AlphaFold + ColabFold –
GO:0003899Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
0.841 Hit 43.9% 5.96e-09
997 KP13_06740 putative lipoprotein AlphaFold + ColabFold – – 0.84 No Hit 0.0% —
998 KP13_05412 Quinone oxidoreductase PIG3 AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0070402Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. GO:0016651Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
0.84 Hit 41.7% 4.99e-14
999 KP13_04730 MltA-interacting protein mipA AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.
0.84 No Hit 0.0% —
1000 KP13_04688 hypothetical protein AlphaFold + ColabFold – – 0.84 No Hit 0.0% —
Page of 208 · 5192 total proteins