Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1126 KP13_02615 Multidrug resistance protein B emrB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.822 No Hit 0.0% —
1127 KP13_00962 Anaerobic glycerol-3-phosphate dehydrogenase subunit A glpA AlphaFold + ColabFold
1.1.5.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0009331An enzyme complex that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate, with concurrent reduction of flavin adenine dinucleotide (FAD) to FADH2. In E. coli, the complex is either a GlpA-GlpB-GlpC heterotrimer that functions in anaerobic conditions, or a GlpD homodimer that functions in aerobic conditions. +710 total
0.822 Hit 50.0% 5.53e-06
1128 KP13_00508 Entericidin B ecnB AlphaFold + ColabFold –
GO:0009636Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.822 No Hit 0.0% —
1129 KP13_31633 Phosphoheptose isomerase gmhA AlphaFold + ColabFold
5.3.1.28
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0008968Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate. GO:0097367Binding to a carbohydrate derivative. +47 total
0.821 No Hit 0.0% —
1130 KP13_05607 hypothetical protein AlphaFold + ColabFold –
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA.
0.821 No Hit 0.0% —
1131 KP13_05270 putative dehydrogenase AlphaFold + ColabFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.821 Hit 44.3% 1.46e-15
1132 KP13_04672 Phenylalanyl-tRNA synthetase beta chain pheT AlphaFold + ColabFold
6.1.1.20
GO:0004826Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). GO:0000049Binding to a transfer RNA. GO:0006432The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. +47 total
0.821 Hit 22.7% 5.50e-10
1133 KP13_05154 Superoxide dismutase Cu-Zn sodC AlphaFold + ColabFold
1.15.1.1
GO:0005507Binding to a copper (Cu) ion. GO:0006801The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. GO:0046872Binding to a metal ion. +14 total
0.82 Hit 30.9% 2.59e-06
1134 KP13_04130 Protein kinase-like domain-containing protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006468The process of introducing a phosphate group on to a protein. GO:0004672Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
0.82 No Hit 0.0% —
1135 KP13_03789 Wzy polymerase in cps region wzy AlphaFold + ColabFold – – 0.82 No Hit 0.0% —
1136 KP13_03607 Copper-exporting P-type ATPase A copA AlphaFold + ColabFold
7.2.2.8
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0046872Binding to a metal ion. +1316 total
0.82 Hit 41.3% 1.09e-10
1137 KP13_02729 Endonuclease-1 endA AlphaFold + ColabFold –
GO:0004518Catalysis of the cleavage of ester linkages within nucleic acids. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.82 No Hit 0.0% —
1138 KP13_01570 Para-aminobenzoate synthase component 1 pabB AlphaFold + ColabFold
2.6.1.85
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0009396The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. GO:0046820Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. +36 total
0.82 No Hit 0.0% —
1139 KP13_01546 Endo-type membrane-bound lytic murein transglycosylase A emtA AlphaFold + ColabFold
4.2.2.n1
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000270The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008933Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. +25 total
0.82 No Hit 0.0% —
1140 KP13_00773 DNA-directed RNA polymerase subunit alpha rpoA AlphaFold + ColabFold
2.7.7.6
GO:0003899Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. GO:0006351The synthesis of an RNA transcript from a DNA template. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
0.82 No Hit 0.0% —
1141 KP13_05271 Major facilitator superfamily transporter AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.819 Hit 31.7% 2.63e-07
1142 KP13_04292 Sugar phosphatase supH supH AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.819 No Hit 0.0% —
1143 KP13_03346 Lipoyl synthase lipA AlphaFold + ColabFold
2.8.1.8
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016992Catalysis of the reaction: [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
0.819 Hit 45.1% 4.07e-48
1144 KP13_05086 3-hydroxyacyl-CoA dehydrogenase AlphaFold + ColabFold
1.1.1.45
GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +36 total
0.818 Hit 34.8% 5.01e-15
1145 KP13_04904 NADH dehydrogenase ndh AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. GO:0019646A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient.
0.818 No Hit 0.0% —
1146 KP13_04713 Nitrite extrusion protein 1 narK AlphaFold + ColabFold –
GO:0015707The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015112Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +710 total
0.818 No Hit 0.0% —
1147 KP13_04186 Chromosome partition protein mukE mukE AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0030261The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. +36 total
0.818 No Hit 0.0% —
1148 KP13_03820 TPR repeat-containing protein AlphaFold + ColabFold
3.4.-.-
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +69 total
0.818 No Hit 0.0% —
1149 KP13_01942 Ribulokinase araB AlphaFold + ColabFold
2.7.1.16
GO:0019569The chemical reactions and pathways resulting in the breakdown of L-arabinose into D-xylulose 5-phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +47 total
0.818 Hit 25.1% 2.82e-20
1150 KP13_07457 RCK domain-containing protein AlphaFold + ColabFold –
GO:0006813The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008324Enables the transfer of cation from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.817 No Hit 0.0% —
Page of 208 · 5192 total proteins