Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1401 KP13_00177 putative ABC transport system, permease component AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.815 No Hit 0.0% —
1402 KP13_00182 HTH-type protein slmA slmA Experimental + ColabFold –
GO:0010974Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.11 No Hit 0.0% —
1403 KP13_00185 hypothetical protein AlphaFold + ColabFold –
GO:0046872Binding to a metal ion. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.7 No Hit 0.0% —
1404 KP13_00189 Phosphopantetheine adenylyltransferase coaD Experimental + ColabFold
2.7.7.3
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0015937The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
0.457 No Hit 0.0% —
1405 KP13_00190 Lipopolysaccharide core biosynthesis glycosyltransferase waaE waaE AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.687 No Hit 0.0% —
1406 KP13_00191 3-deoxy-D-manno-octulosonic-acid transferase waaA AlphaFold + ColabFold
2.4.99.12
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0043842Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP. +25 total
0.276 No Hit 0.0% —
1407 KP13_00193 putative glycosyltransferase in waa region AlphaFold + ColabFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135The chemical reactions and pathways involving carbohydrate derivative.
0.225 No Hit 0.0% —
1408 KP13_00194 Lipopolysaccharide core biosynthesis protein rfaG rfaG AlphaFold + ColabFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135The chemical reactions and pathways involving carbohydrate derivative.
0.672 No Hit 0.0% —
1409 KP13_00195 Lipopolysaccharide core heptosyltransferase rfaQ rfaQ AlphaFold + ColabFold
2.4.99.25
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008713Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. +14 total
0.725 No Hit 0.0% —
1410 KP13_00196 putative protein in waa region AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
0.556 No Hit 0.0% —
1411 KP13_00197 putative heptosyltransferas in waa region AlphaFold + ColabFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008713Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. +14 total
0.547 No Hit 0.0% —
1412 KP13_00198 O-antigen ligase protein in waa region waaL AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.87 No Hit 0.0% —
1413 KP13_00199 lipopolysaccharide core biosynthesis protein RfaZ rfaZ AlphaFold + ColabFold – – 0.478 No Hit 0.0% —
1414 KP13_00200 Lipopolysaccharide heptosyltransferase 1 rfaC AlphaFold + ColabFold
2.4.99.23
GO:0009244The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0008920Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+. +36 total
0.118 No Hit 0.0% —
1415 KP13_00201 ADP-heptose--LPS heptosyltransferase 2 rfaF AlphaFold + ColabFold
2.4.99.24
GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.05 No Hit 0.0% —
1416 KP13_00205 putative glycosyltransferase, family 2 AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.468 No Hit 0.0% —
1417 KP13_00206 hypothetical protein AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
0.35 No Hit 0.0% —
1418 KP13_00208 2,3-bisphosphoglycerate-independent phosphoglycerate mutase gpmI AlphaFold + ColabFold
5.4.2.12
GO:0004619Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate. GO:0030145Binding to a manganese ion (Mn). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
0.425 No Hit 0.0% —
1419 KP13_00210 rhodanese-like domain-containing protein AlphaFold + ColabFold – – 0.416 No Hit 0.0% —
1420 KP13_00212 Protein-export protein secB secB AlphaFold + ColabFold –
GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0051082Binding to an unfolded protein. GO:0051262The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. +25 total
0.834 No Hit 0.0% —
1421 KP13_00214 Serine acetyltransferase cysE Experimental + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0009001Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA. +14 total
0.415 No Hit 0.0% —
1422 KP13_00215 putative tRNA/rRNA methyltransferase AlphaFold + ColabFold
2.1.1.207
GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +811 total
0.475 No Hit 0.0% —
1423 KP13_00217 Putative L-lactate dehydrogenase operon regulatory protein lldR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.138 No Hit 0.0% —
1424 KP13_00218 L-lactate permease lldP AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015129Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. GO:0015727The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. +14 total
0.834 No Hit 0.0% —
1425 KP13_00219 hypothetical protein AlphaFold + ColabFold – – 0.393 No Hit 0.0% —
Page of 234 · 5842 total proteins