Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1451 KP13_31937 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.829 No Hit 0.0% —
1452 KP13_16529 Transport-associated and nodulation domain-containing protein AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map N/A 0.829 No Hit 0.0% —
1453 KP13_04085 Metal-dependent phosphohydrolase AlphaFold DB model + ColabFold model – – No map 0.829 0.538 No Hit 0.0% —
1454 KP13_02359 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. +58 total
No map 0.829 0.134 No Hit 0.0% —
1455 KP13_02149 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.829 No Hit 0.0% —
1456 KP13_01589 Protease htpX htpX AlphaFold DB model + ColabFold model
3.4.24.-
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.829 0.678 No Hit 0.0% —
1457 KP13_00831 Serine hydroxymethyltransferase glyA AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0035999The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesize other tetrahydrofolate molecules. GO:0004372Catalysis of the reaction: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine. +25 total
No map 0.829 0.418 Hit 57.0% 6.95e-42
1458 KP13_32204 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.828 No Hit 0.0% —
1459 KP13_31563 Endoglucanase AlphaFold DB model + ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond.
No map 0.828 0.469 No Hit 0.0% —
1460 KP13_14812 Arginine exporter protein argO argO AlphaFold DB model + ColabFold model –
GO:0061459Enables the transfer of L-arginine from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:1903826The directed movement of L-arginine across a membrane. +25 total
No map 0.828 0.912 No Hit 0.0% —
1461 KP13_05429 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.828 0.268 No Hit 0.0% —
1462 KP13_03473 RNA polymerase sigma factor 54, interaction domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
No map 0.828 0.846 No Hit 0.0% —
1463 KP13_02945 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.828 No Hit 0.0% —
1464 KP13_02572 Formate hydrogenlyase regulatory protein hycA hycA AlphaFold DB model + ColabFold model – – No map N/A 0.828 No Hit 0.0% —
1465 KP13_01614 Pyruvate kinase II pykA AlphaFold DB model + ColabFold model
2.7.1.40
GO:0030955Binding to a potassium ion (K+). GO:0000287Binding to a magnesium (Mg) ion. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +47 total
No map 0.828 0.537 Hit 50.0% 5.61e-06
1466 KP13_05130 type VI secretion ATPase, ClpV1 family AlphaFold DB model + ColabFold model – – No map N/A 0.826 No Hit 0.0% —
1467 KP13_04082 carboxylyase-related protein Experimental + ColabFold model –
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
No map 0.826 0.858 No Hit 0.0% —
1468 KP13_03604 Protein qmcA qmcA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No map N/A 0.826 Hit 51.0% 5.95e-07
1469 KP13_03135 putative phosphatidic acid phosphatase protein in cps region AlphaFold DB model + ColabFold model – – No map 0.826 0.897 No Hit 0.0% —
1470 KP13_02704 putative outer membrane protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
No map 0.826 0.922 No Hit 0.0% —
1471 KP13_02625 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.826 No Hit 0.0% —
1472 KP13_02399 Alkaline phosphatase isozyme conversion protein iap AlphaFold DB model + ColabFold model –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008235Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0004177Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. +14 total
No map 0.826 0.369 No Hit 0.0% —
1473 KP13_04250 Inner membrane protein AlphaFold DB model + ColabFold model – – No map 0.825 0.964 No Hit 0.0% —
1474 KP13_04188 Protein smtA smtA AlphaFold DB model + ColabFold model
2.1.1.-
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0097697Catalysis of the reaction: 5-carboxymethoxyuridine34 in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine34 in tRNA + S-adenosyl-L-homocysteine. The methylation occurs on the modified base. GO:0032259The process in which a methyl group is covalently attached to a molecule. +14 total
No map 0.825 0.933 No Hit 0.0% —
1475 KP13_03628 HTH-type transcriptional regulator AcrR acrR AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +25 total
No map 0.825 0.869 No Hit 0.0% —
Page of 234 · 5842 total proteins