Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1626 KP13_04708 putative transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.727 No Hit 0.0% —
1627 KP13_03446 putative drug/metabolite transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.727 No Hit 0.0% —
1628 KP13_02848 PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit dhaK dhaK AlphaFold + ColabFold
2.7.1.121
GO:0004371Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.727 Hit 48.1% 2.19e-36
1629 KP13_02797 hypothetical protein AlphaFold + ColabFold – – 0.727 No Hit 0.0% —
1630 KP13_02101 Penicillin-binding protein ampH ampH AlphaFold + ColabFold –
GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain.
0.727 Hit 30.3% 3.80e-16
1631 KP13_00252 4-hydroxybenzoate transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.727 Hit 31.7% 3.87e-06
1632 KP13_03384 hypothetical protein AlphaFold + ColabFold – – 0.726 No Hit 0.0% —
1633 KP13_03169 FGGY carbohydrate kinase domain-containing protein AlphaFold + ColabFold –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +36 total
0.726 Hit 49.4% 5.24e-51
1634 KP13_01485 hypothetical protein AlphaFold + ColabFold – – 0.726 No Hit 0.0% —
1635 KP13_00237 Xylose import ATP-binding protein xylG xylG AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015614Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) = ADP + phosphate + D-xylose(in). GO:0015753The process in which D-xylose is transported across a lipid bilayer, from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides. +36 total
0.726 Hit 33.7% 4.20e-09
1636 KP13_00031 Phosphate transport system permease protein pstC pstC AlphaFold + ColabFold –
GO:0005315Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006817The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.726 No Hit 0.0% —
1637 KP13_04308 DNA protection during starvation protein dps AlphaFold + ColabFold
1.16.-.-
GO:0008199Binding to a ferric iron ion, Fe(III). GO:0016722Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
0.725 No Hit 0.0% —
1638 KP13_03493 Helix-turn-helix type 3 domain-containing protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0001046Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
0.725 No Hit 0.0% —
1639 KP13_03138 CBS domain-containing protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.725 No Hit 0.0% —
1640 KP13_01784 Prolyl-tRNA synthetase proS AlphaFold + ColabFold
6.1.1.15
GO:0004827Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. +69 total
0.725 Hit 45.6% 6.86e-64
1641 KP13_01610 Phosphogluconate dehydratase edd AlphaFold + ColabFold
4.2.1.12
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0009255A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
0.725 No Hit 0.0% —
1642 KP13_00195 Lipopolysaccharide core heptosyltransferase rfaQ rfaQ AlphaFold + ColabFold
2.4.99.25
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008713Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. +14 total
0.725 No Hit 0.0% —
1643 KP13_05335 Fe(3+)-citrate import system permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.724 No Hit 0.0% —
1644 KP13_05113 Oligopeptide ABC transport system ATP-binding component AlphaFold + ColabFold
7.4.2.9
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
0.724 Hit 34.4% 4.11e-06
1645 KP13_04900 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.724 No Hit 0.0% —
1646 KP13_04680 putative salt-induced outer membrane protein AlphaFold + ColabFold – – 0.724 No Hit 0.0% —
1647 KP13_04173 Serine transporter AlphaFold + ColabFold –
GO:0003333The process in which an amino acid is transported across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.724 No Hit 0.0% —
1648 KP13_04003 DNA-damage-inducible protein I dinI AlphaFold + ColabFold –
GO:0009432An error-prone process for repairing damaged microbial DNA.
0.724 No Hit 0.0% —
1649 KP13_03145 Signal transduction response regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +47 total
0.724 No Hit 0.0% —
1650 KP13_02748 Ornithine decarboxylase, constitutive speC AlphaFold + ColabFold
4.1.1.17
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. +58 total
0.724 No Hit 0.0% —
Page of 208 · 5192 total proteins