Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
151 KP13_00577 ATP-dependent protease hslV hslV AlphaFold + ColabFold
3.4.25.2
GO:0004298Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0051603OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. +36 total
0.059 No Hit 0.0% —
152 KP13_01836 General secretion pathway protein C Experimental + AlphaFold + ColabFold –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0005515Binding to a protein. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. +14 total
0.059 No Hit 0.0% —
153 KP13_02156 Fimbria A protein smfA AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.06 No Hit 0.0% —
154 KP13_00274 hypothetical protein AlphaFold + ColabFold – – 0.061 No Hit 0.0% —
155 KP13_00725 putative phosphoribulokinase prkB AlphaFold + ColabFold
2.7.1.19
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +14 total
0.061 No Hit 0.0% —
156 KP13_02229 Fimbrin-like protein fimI fimI AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.061 No Hit 0.0% —
157 KP13_04651 hypothetical protein AlphaFold + ColabFold – – 0.061 No Hit 0.0% —
158 KP13_01660 putative amino-acid ABC transporter ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
0.062 Hit 37.1% 5.41e-27
159 KP13_31886 putative reverse transcriptase retA AlphaFold + ColabFold – – 0.062 No Hit 0.0% —
160 KP13_31958 putative reverse transcriptase AlphaFold + ColabFold – – 0.062 No Hit 0.0% —
161 KP13_31995 putative reverse transcriptase AlphaFold + ColabFold – – 0.062 No Hit 0.0% —
162 KP13_32366 putative reverse transcriptase AlphaFold + ColabFold –
GO:0003964Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time.
0.062 No Hit 0.0% —
163 KP13_00787 hypothetical protein AlphaFold + ColabFold – – 0.065 No Hit 0.0% —
164 KP13_00581 6-phosphofructokinase pfkA AlphaFold + ColabFold
2.7.1.11
GO:0008443Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule. GO:0006002The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +1013 total
0.066 Hit 57.8% 6.10e-09
165 KP13_02035 Transcriptional activator protein BglJ bgIJ AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.067 No Hit 0.0% —
166 KP13_02197 Single-stranded-DNA-specific exonuclease recJ recJ AlphaFold + ColabFold –
GO:0008409Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. GO:0003676Binding to a nucleic acid. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +14 total
0.067 No Hit 0.0% —
167 KP13_02502 4-hydroxyphenylacetate 3-monooxygenase reductase component hpaC AlphaFold + ColabFold
1.5.1.36
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016651Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +47 total
0.067 No Hit 0.0% —
168 KP13_02556 N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component chbA AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0046872Binding to a metal ion. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.067 No Hit 0.0% —
169 KP13_05504 GCN5-related N-acetyltransferase AlphaFold + ColabFold
2.3.1.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.067 No Hit 0.0% —
170 KP13_31608 putative lipoprotein AlphaFold + ColabFold – – 0.067 No Hit 0.0% —
171 KP13_01498 hypothetical protein AlphaFold + ColabFold – – 0.068 No Hit 0.0% —
172 KP13_05032 Methylated-DNA--protein-cysteine methyltransferase ogt AlphaFold + ColabFold
2.1.1.63
GO:0003908Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +36 total
0.069 Hit 45.5% 2.50e-21
173 KP13_01374 NADH pyrophosphatase nudC AlphaFold + ColabFold
3.6.1.- 3.6.1.22
GO:0000210Catalysis of the reaction: NAD+ + H2O = AMP + NMN. GO:0046872Binding to a metal ion. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +811 total
0.07 Hit 40.7% 1.43e-19
174 KP13_01708 Protein cyaY cyaY AlphaFold + ColabFold –
GO:0008199Binding to a ferric iron ion, Fe(III). GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.07 No Hit 0.0% —
175 KP13_02639 hypothetical protein AlphaFold + ColabFold – – 0.07 No Hit 0.0% —
Page of 234 · 5842 total proteins