Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1801 KP13_00824 hypothetical protein AlphaFold + ColabFold – – 0.568 No Hit 0.0% —
1802 KP13_00825 Putative sensor-like histidine kinase AlphaFold + ColabFold –
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. +14 total
0.706 No Hit 0.0% —
1803 KP13_00826 hypothetical protein AlphaFold + ColabFold – – 0.194 No Hit 0.0% —
1804 KP13_00827 signal transduction response regulator protein AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. +36 total
0.25 No Hit 0.0% —
1805 KP13_00828 Nitrogen regulatory protein P-II glnB AlphaFold + ColabFold –
GO:0030234A molecular function regulator that modulates a catalytic activity. GO:0006808Any process that modulates the frequency, rate or extent of nitrogen utilization. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.102 No Hit 0.0% —
1806 KP13_00830 hypothetical protein ColabFold – – 0.423 No Hit 0.0% —
1807 KP13_00832 Inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.948 No Hit 0.0% —
1808 KP13_00834 Tetratricopeptide repeat-containing protein AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.736 No Hit 0.0% —
1809 KP13_00836 putative epimerase AlphaFold + ColabFold –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +14 total
0.767 No Hit 0.0% —
1810 KP13_00837 putative 3-phenylpropionic acid transporter hcaT AlphaFold + ColabFold – – 0.87 No Hit 0.0% —
1811 KP13_00838 Stationary phase-inducible protein CsiE csiE AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.282 No Hit 0.0% —
1812 KP13_00839 hypothetical protein AlphaFold + ColabFold – – 0.151 No Hit 0.0% —
1813 KP13_00840 Nickel/cobalt efflux system AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0035444The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. GO:0015099Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. +47 total
0.976 No Hit 0.0% —
1814 KP13_00841 hypothetical protein AlphaFold + ColabFold – – 0.707 No Hit 0.0% —
1815 KP13_00843 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ trmJ AlphaFold + ColabFold
2.1.1.200
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
0.352 No Hit 0.0% —
1816 KP13_00844 HTH-type transcriptional regulator iscR iscR AlphaFold + ColabFold –
GO:0003690Binding to double-stranded DNA. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.096 No Hit 0.0% —
1817 KP13_00851 Protein iscX iscX AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
0.098 No Hit 0.0% —
1818 KP13_00853 Protein sseB sseB AlphaFold + ColabFold – – 0.528 No Hit 0.0% —
1819 KP13_00854 hypothetical protein AlphaFold + ColabFold – – 0.968 No Hit 0.0% —
1820 KP13_00857 Penicillin-binding protein 1C pbpC AlphaFold + ColabFold
2.4.99.28
GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0008955Catalysis of the reaction: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+. +36 total
0.635 No Hit 0.0% —
1821 KP13_00859 Ribosomal RNA large subunit methyltransferase N rlmN AlphaFold + ColabFold
2.1.1.192
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0030488The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. GO:0070475The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. +1013 total
0.583 No Hit 0.0% —
1822 KP13_00860 Cytoskeleton protein rodZ rodZ AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008360Any process that modulates the surface configuration of a cell. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
0.457 No Hit 0.0% —
1823 KP13_00861 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase ispG AlphaFold + ColabFold –
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0016114The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. GO:0005506Binding to an iron (Fe) ion. +25 total
0.458 No Hit 0.0% —
1824 KP13_00863 hypothetical protein AlphaFold + ColabFold –
GO:0044877Binding to a macromolecular complex. GO:0005515Binding to a protein. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.395 No Hit 0.0% —
1825 KP13_00864 Lipoprotein Experimental + ColabFold –
GO:0005515Binding to a protein. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. +14 total
0.438 No Hit 0.0% —
Page of 234 · 5842 total proteins