Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1951 KP13_04762 hypothetical protein AlphaFold + ColabFold – – 0.667 No Hit 0.0% —
1952 KP13_04281 Glutathione transport system permease protein gsiD gsiD AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.667 No Hit 0.0% —
1953 KP13_03378 HTH-type transcriptional repressor purR purR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.667 No Hit 0.0% —
1954 KP13_04632 FeS cluster assembly protein sufB sufB AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
0.666 No Hit 0.0% —
1955 KP13_01753 hypothetical protein AlphaFold + ColabFold – – 0.666 No Hit 0.0% —
1956 KP13_01525 High-affinity branched-chain amino acid transport ATP-binding protein braG braG AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +14 total
0.666 Hit 34.4% 4.84e-09
1957 KP13_01077 Ribosomal RNA small subunit methyltransferase I rsmI AlphaFold + ColabFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule.
0.666 No Hit 0.0% —
1958 KP13_04488 Putative transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.665 No Hit 0.0% —
1959 KP13_04190 kinase-like domain-containing protein AlphaFold + ColabFold – – 0.665 No Hit 0.0% —
1960 KP13_03725 hypothetical protein AlphaFold + ColabFold – – 0.665 No Hit 0.0% —
1961 KP13_02092 Extensin-like protein AlphaFold + ColabFold – – 0.665 No Hit 0.0% —
1962 KP13_00820 hypothetical protein AlphaFold + ColabFold
3.1.3.27
GO:0046872Binding to a metal ion. GO:0008962Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.
0.665 No Hit 0.0% —
1963 KP13_00330 Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF arnF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:1901505Enables the transfer of carbohydrate derivative from one side of a membrane to the other. +14 total
0.665 No Hit 0.0% —
1964 KP13_31536 putative transposase AlphaFold + ColabFold – – 0.664 No Hit 0.0% —
1965 KP13_03224 Mannonate dehydratase uxuA AlphaFold + ColabFold
4.2.1.8
GO:0008927Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. GO:0006064The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid. GO:0008198Binding to a ferrous iron ion, Fe(II). +25 total
0.664 No Hit 0.0% —
1966 KP13_01810 Elongation factor Ts tsf AlphaFold + ColabFold –
GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0005515Binding to a protein. GO:0006414The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. +14 total
0.664 Hit 36.1% 3.51e-12
1967 KP13_05517 Nitronate monooxygenase AlphaFold + ColabFold –
GO:0018580Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite.
0.663 No Hit 0.0% —
1968 KP13_05363 HTH-type transcriptional regulator ttuA AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
0.663 No Hit 0.0% —
1969 KP13_05355 Anthranilate synthase component 1 trpE AlphaFold + ColabFold
4.1.3.27
GO:0004049Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0046872Binding to a metal ion. +14 total
0.663 No Hit 0.0% —
1970 KP13_05259 putative transport protein AlphaFold + ColabFold
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate. +25 total
0.663 No Hit 0.0% —
1971 KP13_05106 putative dioxygenase AlphaFold + ColabFold –
GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0046872Binding to a metal ion.
0.663 No Hit 0.0% —
1972 KP13_04985 RND efflux system, membrane fusion protein AlphaFold + ColabFold –
GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.663 No Hit 0.0% —
1973 KP13_04955 Glyoxylate/hydroxypyruvate reductase A bifunctional protein ghrA AlphaFold + ColabFold
1.1.1.79 1.1.1.81
GO:0016618Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0030267Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. +36 total
0.663 Hit 37.5% 2.30e-06
1974 KP13_32079 hypothetical protein AlphaFold + ColabFold – – 0.662 No Hit 0.0% —
1975 KP13_05547 Phosphotriesterase family protein AlphaFold + ColabFold –
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0008270Binding to a zinc ion (Zn). GO:0009056A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
0.662 Hit 35.5% 3.60e-35
Page of 208 · 5192 total proteins