Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
201 KP13_00850 2Fe-2S ferredoxin fdx AlphaFold + ColabFold –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0140647A electron transport chain in which one or more electron carriers operate to transfer electrons from donors to a cytochrome P450 protein or domain. Electron carriers operating in this chain include FAD-containing flavoproteins or domains, FMN domains, ferredoxins and cytochrome b5. The reduced cytochrome P450 functions as the terminal oxidase and participates in a wide range of biochemical pathways. +36 total
0.563 Hit 41.1% 5.00e-14
202 KP13_00855 3-mercaptopyruvate sulfurtransferase sseA AlphaFold + ColabFold –
GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.404 Hit 41.4% 1.62e-67
203 KP13_00856 putative lipoprotein AlphaFold + ColabFold –
GO:0004866Binds to and stops, prevents or reduces the activity of an endopeptidase. GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
0.307 Hit 26.1% 3.54e-06
204 KP13_00858 Nucleoside diphosphate kinase ndk AlphaFold + ColabFold
2.7.4.6
GO:0006183The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. GO:0006241The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. GO:0004550Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. +47 total
0.721 Hit 51.4% 1.87e-18
205 KP13_00862 Histidyl-tRNA synthetase hisS AlphaFold + ColabFold
6.1.1.21
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004821Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.645 Hit 25.3% 6.26e-11
206 KP13_00865 GTP-binding protein engA engA AlphaFold + ColabFold –
GO:0005525Binding to GTP, guanosine triphosphate. GO:0043022Binding to a ribosome. GO:0042254A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
0.754 Hit 27.7% 4.35e-10
207 KP13_00869 Inosine-5'-monophosphate dehydrogenase guaB AlphaFold + ColabFold
1.1.1.205
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003938Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
0.501 Hit 50.4% 6.61e-27
208 KP13_00870 GMP synthase guaA AlphaFold + ColabFold –
GO:0006164The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0003922Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +25 total
0.019 Hit 36.5% 2.23e-93
209 KP13_00926 Alkaline-phosphatase-like protein AlphaFold + ColabFold –
GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. GO:0004065Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. GO:0015024Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate.
0.756 Hit 32.4% 7.52e-06
210 KP13_00936 GDP-mannose pyrophosphatase nudK nudK AlphaFold + ColabFold –
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0046872Binding to a metal ion. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.491 Hit 33.1% 2.04e-09
211 KP13_00946 putative ABC transporter ATP-binding protein AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. +69 total
0.79 Hit 44.6% 2.44e-09
212 KP13_00947 Alpha-ketoglutarate-dependent dioxygenase alkB alkB AlphaFold + ColabFold
1.14.11.33
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0035516Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA. GO:0008198Binding to a ferrous iron ion, Fe(II). +36 total
0.856 Hit 32.5% 4.06e-14
213 KP13_00948 Regulatory protein ada ada AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +811 total
0.233 Hit 30.7% 3.70e-15
214 KP13_00955 DNA gyrase subunit A gyrA AlphaFold + ColabFold
5.6.2.2
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. +811 total
0.336 Hit 27.6% 1.59e-15
215 KP13_00956 3-demethylubiquinone-9 3-methyltransferase ubiG AlphaFold + ColabFold
2.1.1.222 2.1.1.64
GO:0008425Catalysis of the reaction: a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-homocysteine + H+. GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. GO:0102208Catalysis of the reaction: a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H+ + S-adenosyl-L-homocysteine. +36 total
0.997 Hit 33.1% 1.62e-46
216 KP13_00958 Ribonucleoside-diphosphate reductase 1 subunit alpha nrdA AlphaFold + ColabFold
1.17.4.1
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0004748Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. +25 total
0.354 Hit 27.6% 6.44e-51
217 KP13_00959 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB AlphaFold + ColabFold
1.17.4.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0009263The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0046872Binding to a metal ion. +14 total
0.425 Hit 24.2% 5.75e-11
218 KP13_00960 Glycerophosphoryl diester phosphodiesterase glpQ AlphaFold + ColabFold
3.1.4.46
GO:0008081Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +25 total
0.642 Hit 32.6% 4.60e-07
219 KP13_00961 Glycerol-3-phosphate transporter glpT AlphaFold + ColabFold –
GO:0015794The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015169Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol. +58 total
0.564 Hit 29.5% 1.84e-33
220 KP13_00962 Anaerobic glycerol-3-phosphate dehydrogenase subunit A glpA AlphaFold + ColabFold
1.1.5.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0009331An enzyme complex that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate, with concurrent reduction of flavin adenine dinucleotide (FAD) to FADH2. In E. coli, the complex is either a GlpA-GlpB-GlpC heterotrimer that functions in anaerobic conditions, or a GlpD homodimer that functions in aerobic conditions. +710 total
0.822 Hit 50.0% 5.53e-06
221 KP13_00966 Inner membrane transport protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.797 Hit 24.1% 2.35e-11
222 KP13_00969 CinA-like protein AlphaFold + ColabFold – – 0.43 Hit 28.1% 7.07e-09
223 KP13_00973 2-succinylbenzoate--CoA ligase menE AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008756Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate. GO:0009234The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2.
0.121 Hit 31.0% 3.20e-12
224 KP13_00975 Naphthoate synthase menB AlphaFold + ColabFold
4.1.3.36
GO:0009234The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008935Catalysis of the reaction: 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O. +14 total
0.936 Hit 34.8% 2.50e-17
225 KP13_00976 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase menH AlphaFold + ColabFold
4.2.99.20
GO:0009234The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2. GO:0070205Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate.
0.728 Hit 21.5% 4.34e-08
Page of 234 · 5842 total proteins