Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_00088 transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.000 0.29 No Hit 0.0% —
2 KP13_00990 NADH-quinone oxidoreductase subunit E nuoE AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. +25 total
No map 0.000 0.506 Hit 35.0% 6.27e-27
3 KP13_04277 Biofilm regulator bssR bssR AlphaFold DB model + ColabFold model – – No map 0.001 0.34 No Hit 0.0% —
4 KP13_05719 Propanediol utilization protein pduA AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.001 0.532 No Hit 0.0% —
5 KP13_32001 hypothetical protein ColabFold model – – No map 0.001 0.619 No Hit 0.0% —
6 KP13_32140 hypothetical protein ColabFold model – – No map 0.001 0.687 No Hit 0.0% —
7 KP13_00394 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.002 0.128 No Hit 0.0% —
8 KP13_00490 suppressor of F exclusion of phage T7 fxsA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.002 0.945 No Hit 0.0% —
9 KP13_01403 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.002 0.668 No Hit 0.0% —
10 KP13_01560 putative septum site-determining protein minC minC AlphaFold DB model + ColabFold model –
GO:0051302Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. GO:0051726Any process that modulates the rate or extent of progression through the cell cycle. GO:0000902The developmental process in which the size or shape of a cell is generated and organized. +25 total
No map 0.002 0.596 No Hit 0.0% —
11 KP13_01787 peptidyl-tRNA hydrolase domain-containing protein AlphaFold DB model + ColabFold model
3.1.1.29
GO:0003747Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. GO:0006415The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
No map 0.002 0.212 No Hit 0.0% —
12 KP13_02168 hypothetical protein ColabFold model – – No map 0.002 0.794 No Hit 0.0% —
13 KP13_02601 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.002 0.482 No Hit 0.0% —
14 KP13_02687 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.002 0.45 No Hit 0.0% —
15 KP13_02750 putative transposase AlphaFold DB model + ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.002 0.164 No Hit 0.0% —
16 KP13_03082 putative transmembrane protein ColabFold model – – No map 0.002 0.3 No Hit 0.0% —
17 KP13_03620 nucleoid-associated protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.002 0.328 No Hit 0.0% —
18 KP13_03629 Acriflavine resistance protein A acrA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +47 total
No map 0.002 0.448 No Hit 0.0% —
19 KP13_04012 putative lysozyme from lambdoid prophage DLP12 arrD AlphaFold DB model + ColabFold model –
GO:0009253The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0003796Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. GO:0016998The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall.
No map 0.002 0.476 No Hit 0.0% —
20 KP13_04197 Integration host factor subunit beta ihfB AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. +47 total
No map 0.002 0.367 No Hit 0.0% —
21 KP13_04308 DNA protection during starvation protein dps AlphaFold DB model + ColabFold model
1.16.-.-
GO:0008199Binding to a ferric iron ion, Fe(III). GO:0016722Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
No map 0.002 0.725 No Hit 0.0% —
22 KP13_04934 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.002 0.585 No Hit 0.0% —
23 KP13_05245 Putative prolyl endopeptidase AlphaFold DB model + ColabFold model – – No map 0.002 0.564 No Hit 0.0% —
24 KP13_01917 Acetolactate synthase isozyme 3 small subunit ilvH AlphaFold DB model + ColabFold model
2.2.1.6
GO:1990610Binds to and modulates the activity of acetolactate synthase. GO:0009082The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No map 0.003 0.712 No Hit 0.0% —
25 KP13_02345 putative sufE-like protein AlphaFold DB model + ColabFold model – – No map 0.003 0.598 No Hit 0.0% —
Page of 234 · 5842 total proteins