Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4351 PA2440 hypothetical protein PA2440 AlphaFold – – 0.548 No Hit N/A —
4352 PA4465 hypothetical protein PA4465 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005525Binding to GTP, guanosine triphosphate. GO:0060090The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
0.547 No Hit N/A —
4353 PA4326 hypothetical protein PA4326 AlphaFold –
GO:0005515Binding to a protein.
0.547 No Hit N/A —
4354 PA3759 aminotransferase PA3759 AlphaFold –
GO:0097367Binding to a carbohydrate derivative. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:1901135The chemical reactions and pathways involving carbohydrate derivative.
0.547 Hit 26.8% 2.12e-22
4355 PA2213 porin PA2213 Experimental + AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
0.547 No Hit N/A —
4356 PA2012 methylcrotonyl-CoA carboxylase subunit alpha liuD, PA2012 Experimental + AlphaFold –
GO:1905202A protein complex capable of methylcrotonoyl-CoA carboxylase activity. In mammals, it is a mitochondrial complex comprising a dodecamer of 6 alpha and 6 beta subunits: MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation; MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004075Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. +58 total
0.547 Hit 57.4% 4.47e-11
4357 PA1511 hypothetical protein vgrG2a, PA1511 AlphaFold –
GO:0033104A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence. GO:0033103The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
0.547 No Hit N/A —
4358 PA0045 hypothetical protein PA0045 AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.547 No Hit N/A —
4359 PA3989 DNA polymerase III subunit delta PA3989, holA AlphaFold
2.7.7.7
GO:0009360The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. +25 total
0.546 No Hit N/A —
4360 PA3407 heme acquisition protein HasA PA3407, hasAp Experimental + AlphaFold –
GO:0046872Binding to a metal ion.
0.546 No Hit N/A —
4361 PA2755 ecotin PA2755, eco AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0004867Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase.
0.546 No Hit N/A —
4362 PA2225 hypothetical protein PA2225 AlphaFold – – 0.546 No Hit N/A —
4363 PA5176 ADP-ribose diphosphatase NudE PA5176 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019144Catalysis of the reaction: ADP-sugar + H2O = AMP + alpha-D-aldose 1-phosphate. GO:0006753The chemical reactions and pathways involving any phosphorylated nucleoside. +25 total
0.545 Hit 33.7% 6.06e-06
4364 PA5080 prolyl aminopeptidase PA5080 AlphaFold
3.4.11.5
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004177Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +14 total
0.545 Hit 37.0% 7.83e-06
4365 PA3471 NAD-dependent malic enzyme maeA, PA3471 AlphaFold
1.1.1.38
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004471Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. GO:0004470Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. +47 total
0.545 Hit 50.2% 9.13e-82
4366 PA2917 transcriptional regulator PA2917 AlphaFold –
GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.545 No Hit N/A —
4367 PA2192 hypothetical protein PA2192 AlphaFold – – 0.545 No Hit N/A —
4368 PA1988 coenzyme PQQ synthesis protein D PA1988, pqqD AlphaFold –
GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. GO:0018189The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed.
0.545 No Hit N/A —
4369 PA1770 phosphoenolpyruvate synthase PA1770, ppsA AlphaFold
2.7.9.2
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. GO:0008986Catalysis of the reaction: ATP + H2O + pyruvate = AMP + 2 H+ + phosphate + phosphoenolpyruvate. +69 total
0.545 No Hit N/A —
4370 PA1701 hypothetical protein PA1701 AlphaFold –
GO:0030254The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
0.545 No Hit N/A —
4371 PA1428 hypothetical protein PA1428 AlphaFold –
GO:0061733Catalysis of the reaction: L-lysyl-[protein] + acetyl-CoA = N6-acetyl-L-lysyl-[protein] + CoA + H+. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.545 No Hit N/A —
4372 PA0323 ABC transporter PA0323 AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0019810Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. GO:0019809Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. +47 total
0.545 No Hit N/A —
4373 PA2479 two-component response regulator PA2479 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +47 total
0.544 No Hit N/A —
4374 PA2774 hypothetical protein PA2774, tse4 AlphaFold –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0033644Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction.
0.543 No Hit N/A —
4375 PA2050 RNA polymerase sigma factor PA2050 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. +47 total
0.543 No Hit N/A —
Page of 223 · 5572 total proteins