Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

Search, filter, and prioritize proteins.

Export view
5572 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4576 PA4676 carbonic anhydrase PA4676 Experimental + AlphaFold
4.2.1.1
GO:0004089Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. GO:0008270Binding to a zinc ion (Zn). GO:0015976A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.
0.502 No Hit N/A —
4577 PA3307 hypothetical protein PA3307 AlphaFold – – 0.502 No Hit N/A —
4578 PA1070 ABC transporter ATP-binding protein braG, PA1070 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +58 total
0.502 Hit 32.2% 8.30e-21
4579 PA0937 hypothetical protein PA0937 AlphaFold – – 0.502 No Hit N/A —
4580 PA0126 hypothetical protein PA0126 AlphaFold – – 0.502 No Hit N/A —
4581 PA5556 ATP synthase subunit alpha atpA, PA5556 AlphaFold
7.1.2.2
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045259A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. GO:0043531Binding to ADP, adenosine 5'-diphosphate. +710 total
0.501 Hit 59.2% 1.17e-52
4582 PA5295 hypothetical protein PA5295 AlphaFold
3.1.4.52
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
0.501 No Hit N/A —
4583 PA4596 transcriptional regulator PA4596 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.501 No Hit N/A —
4584 PA1260 amino acid ABC transporter substrate-binding protein PA1260 AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. GO:0034589The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.501 No Hit N/A —
4585 PA0576 RNA polymerase sigma factor RpoD PA0576, rpoDA, rpoD AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1903865A protein complex which is capable of sigma factor antagonist activity. GO:0003899Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. +69 total
0.501 No Hit N/A —
4586 PA4881 hypothetical protein PA4881 AlphaFold – – 0.5 No Hit N/A —
4587 PA3711 transcriptional regulator PA3711 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.5 No Hit N/A —
4588 PA2037 hypothetical protein PA2037 AlphaFold – – 0.5 No Hit N/A —
4589 PA1001 anthranilate synthase component I trpE, PA1001, phnA AlphaFold
4.1.3.27
GO:0004049Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. GO:0046872Binding to a metal ion. GO:0000162The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate. +25 total
0.5 No Hit N/A —
4590 PA0895 acetylornithine aminotransferase astC, argD, aruC, PA0895 AlphaFold
2.6.1.11 2.6.1.81
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0042802Binding to an identical protein or proteins. GO:0003992Catalysis of the reaction: N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. +912 total
0.5 Hit 34.6% 1.54e-71
4591 PA0769 hypothetical protein PA0769 AlphaFold – – 0.5 No Hit N/A —
4592 PA0167 transcriptional regulator PA0167 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +25 total
0.5 No Hit N/A —
4593 PA4034 aquaporin Z PA4034, aqpZ AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015250Enables the energy-independent facilitated diffusion of water through a transmembrane aqueous pore or channel. GO:0006833The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
0.499 Hit 44.3% 1.91e-09
4594 PA4033 hypothetical protein PA4033 AlphaFold – – 0.499 No Hit N/A —
4595 PA2681 transcriptional regulator PA2681 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
0.499 No Hit N/A —
4596 PA2043 hypothetical protein PA2043 AlphaFold –
GO:0140098Catalytic activity that acts to modify RNA. GO:0009982Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. GO:0003723Binding to an RNA molecule or a portion thereof. +36 total
0.499 Hit 31.2% 2.55e-17
4597 PA4758 carbamoyl phosphate synthase small subunit carA, PA4758 AlphaFold
6.3.5.5
GO:0005951A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +710 total
0.498 Hit 38.9% 5.30e-67
4598 PA4477 cytoplasmic axial filament protein cafA, PA4477 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +912 total
0.498 No Hit N/A —
4599 PA2866 secretion protein MttC PA2866, mttC AlphaFold –
GO:0004527Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. GO:0046872Binding to a metal ion. GO:0016788Catalysis of the hydrolysis of any ester bond.
0.498 Hit 35.8% 3.13e-13
4600 PA1501 hypothetical protein PA1501 AlphaFold –
GO:0008903Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate. GO:0046487The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.
0.498 Hit 43.1% 4.29e-57
Page of 223 · 5572 total proteins