Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5501 PA5406 hypothetical protein PA5406 AlphaFold – – No pocket No Hit N/A —
5502 PA0768 signal peptidase I lepB, PA0768 AlphaFold
3.4.21.89
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +58 total
No pocket No Hit N/A —
5503 PA5540 hypothetical protein PA5540 AlphaFold – – No pocket No Hit N/A —
5504 PA4060 hypothetical protein PA4060 AlphaFold – – No pocket No Hit N/A —
5505 PA5049 50S ribosomal protein L31 rpmE, PA5049 AlphaFold –
GO:1990904A macromolecular complex that contains both RNA and protein molecules. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0046872Binding to a metal ion. +36 total
No pocket No Hit N/A —
5506 PA3585 membrane protein GlpM glpM, PA3585 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042121The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).
No pocket No Hit N/A —
5507 PA4253 50S ribosomal protein L14 PA4253, rplN AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0070180Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +36 total
No pocket Hit 40.6% 1.30e-08
5508 PA3351 protein FlgM PA3351, flgM AlphaFold –
GO:0016989The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. GO:0044781A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
No pocket No Hit N/A —
5509 PA1048 hypothetical protein PA1048 AlphaFold –
GO:0120101A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. GO:0071973Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
No pocket No Hit N/A —
5510 PA2673 type II secretion system protein PA2673 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No pocket No Hit N/A —
5511 PA0184 ABC transporter ATP-binding protein PA0184 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No pocket Hit 45.6% 5.11e-06
5512 PA0038 hypothetical protein PA0038 AlphaFold – – No pocket No Hit N/A —
5513 PA0612 repressor PtrB PA0612, ptrB AlphaFold –
GO:0008270Binding to a zinc ion (Zn). GO:1900378Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.
No pocket No Hit N/A —
5514 PA4108a hypothetical protein ColabFold – – No pocket No Hit N/A —
5515 PA0408 pilus biosynthesis/twitching motility protein PilG PA0408, pilG AlphaFold –
GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
No pocket No Hit N/A —
5516 PA3520 hypothetical protein PA3520 AlphaFold –
GO:0046872Binding to a metal ion.
No pocket No Hit N/A —
5517 PA1965 hypothetical protein PA1965 AlphaFold – – No pocket No Hit N/A —
5518 PA5359 hypothetical protein PA5359 AlphaFold –
GO:0043448The chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2.
No pocket No Hit N/A —
5519 PA1985 coenzyme PQQ synthesis protein A PA1985, pqqA AlphaFold –
GO:0018189The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed.
No pocket No Hit N/A —
5520 PA4736 hypothetical protein PA4736 AlphaFold – – No pocket No Hit N/A —
5521 PA1866a hypothetical protein ColabFold – – No pocket No Hit N/A —
5522 PA4247 50S ribosomal protein L18 PA4247, rplR AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0008097Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +25 total
No pocket No Hit N/A —
5523 PA1058 monovalent cation/H+ antiporter subunit F PA1058 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015385Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). GO:0035725A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. +36 total
No pocket No Hit N/A —
5524 PA3370 hypothetical protein PA3370 AlphaFold – – No pocket No Hit N/A —
5525 PA0022 threonylcarbamoyl-AMP synthase PA0022, rimN, tsaC AlphaFold
2.7.7.87
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003725Binding to double-stranded RNA. +58 total
No pocket Hit 30.3% 2.70e-06
Page of 223 · 5572 total proteins