Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

Search, filter, and prioritize proteins.

Export view
5572 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
626 PA5183 hypothetical protein PA5183 AlphaFold – – 0.911 No Hit N/A —
627 PA5112 esterase estA, PA5112, papA Experimental + AlphaFold
3.1.1.1
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0106435Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+. GO:0052689Catalysis of the hydrolysis of a carboxylic ester bond. +912 total
0.911 No Hit N/A —
628 PA5094 ABC transporter ATP-binding protein PA5094 AlphaFold
7.6.2.9
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0015418Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H+ + phosphate + quaternary ammonium(in). GO:0005275Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. +69 total
0.911 Hit 41.4% 7.39e-06
629 PA4396 two-component response regulator PA4396 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +14 total
0.911 No Hit N/A —
630 PA3787 hypothetical protein PA3787 Experimental + AlphaFold –
GO:0046872Binding to a metal ion. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
0.911 No Hit N/A —
631 PA3494 electron transport complex subunit E PA3494, rnfE AlphaFold
7.-.-.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.911 No Hit N/A —
632 PA3301 hypothetical protein PA3301 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016298Catalysis of the hydrolysis of a lipid.
0.911 Hit 35.4% 8.57e-06
633 PA3042 hypothetical protein PA3042 AlphaFold – – 0.911 No Hit N/A —
634 PA3027 transcriptional regulator PA3027 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.911 No Hit N/A —
635 PA2628 hypothetical protein PA2628 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.911 Hit 25.4% 3.54e-15
636 PA2026 hypothetical protein PA2026 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.911 Hit 28.5% 1.45e-25
637 PA1032 acyl-homoserine lactone acylase QuiP quiP, PA1032 AlphaFold
3.5.1.97
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0017000The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. +25 total
0.911 No Hit N/A —
638 PA1004 quinolinate synthetase nadA, PA1004 AlphaFold
2.5.1.72
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. +47 total
0.911 No Hit N/A —
639 PA0573 hypothetical protein PA0573 AlphaFold – – 0.911 No Hit N/A —
640 PA0446 hypothetical protein PA0446 AlphaFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.911 Hit 47.2% 2.04e-107
641 PA0333 hypothetical protein PA0333 AlphaFold –
GO:0044877Binding to a macromolecular complex. GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
0.911 No Hit N/A —
642 PA5504 D-methionine ABC transporter PA5504 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0048473The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other. GO:1903810The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol. +25 total
0.91 No Hit N/A —
643 PA5216 iron ABC transporter substrate-binding protein PA5216 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.91 No Hit N/A —
644 PA4997 transporter MsbA msbA, PA4997 AlphaFold
7.5.2.6
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +811 total
0.91 Hit 58.4% 9.74e-23
645 PA4649 hypothetical protein PA4649 AlphaFold – – 0.91 No Hit N/A —
646 PA3921 transcriptional regulator PA3921 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005515Binding to a protein.
0.91 No Hit N/A —
647 PA2076 transcriptional regulator PA2076 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.91 No Hit N/A —
648 PA1961 transcriptional regulator PA1961 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.91 No Hit N/A —
649 PA1819 amino acid permease PA1819 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0043862Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.91 Hit 38.6% 8.36e-07
650 PA1286 major facilitator superfamily transporter PA1286 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.91 Hit 27.8% 3.89e-08
Page of 223 · 5572 total proteins