Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
976 PA2091 hypothetical protein PA2091 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.886 Hit 26.3% 2.66e-07
977 PA2056 transcriptional regulator PA2056 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
0.886 No Hit N/A —
978 PA1990 peptidase pqqH, PA1990 AlphaFold –
GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.886 Hit 26.2% 3.76e-12
979 PA0736 hypothetical protein PA0736 AlphaFold – – 0.886 No Hit N/A —
980 PA0485 hypothetical protein PA0485 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.886 No Hit N/A —
981 PA0261 hypothetical protein PA0261, tli3 AlphaFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.886 No Hit N/A —
982 PA4631 hypothetical protein PA4631 Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004029Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.
0.885 No Hit N/A —
983 PA4301 type II secretion system protein TadB PA4301, tadB AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.885 No Hit N/A —
984 PA4027 hypothetical protein PA4027 AlphaFold – – 0.885 No Hit N/A —
985 PA3712 hypothetical protein PA3712 AlphaFold – – 0.885 No Hit N/A —
986 PA3124 transcriptional regulator PA3124 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
0.885 No Hit N/A —
987 PA3028 molybdenum cofactor biosynthesis protein A PA3028, moeA2 AlphaFold
2.10.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046872Binding to a metal ion. +36 total
0.885 Hit 34.0% 5.75e-48
988 PA2988 hypothetical protein PA2988 AlphaFold –
GO:0098797Any protein complex that is part of the plasma membrane. GO:0044874A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. GO:0042953The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.885 No Hit N/A —
989 PA1598 3-methyl-2-oxobutanoate hydroxymethyltransferase PA1598, panB1 AlphaFold
2.1.2.11
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003864Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate. GO:0000287Binding to a magnesium (Mg) ion. +25 total
0.885 No Hit N/A —
990 PA0765 positive regulator for alginate biosynthesis MucC mucC, PA0765 AlphaFold –
GO:1990204Any protein complex that possesses oxidoreductase activity. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0032885Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.
0.885 No Hit N/A —
991 PA0647 hypothetical protein PA0647 AlphaFold – – 0.885 No Hit N/A —
992 PA4525 type 4 fimbrial protein PilA fimA, pilA, PA4525 AlphaFold –
GO:0009986The external part of the cell wall and/or plasma membrane. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0044167The lipid bilayer surrounding the host cell endoplasmic reticulum. +811 total
0.884 No Hit N/A —
993 PA3908 hypothetical protein PA3908 Experimental + AlphaFold – – 0.884 No Hit N/A —
994 PA3821 preprotein translocase subunit SecD PA3821, secD AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015450Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. GO:0065002The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. +47 total
0.884 No Hit N/A —
995 PA3615 hypothetical protein PA3615 AlphaFold
3.2.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008714Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine.
0.884 No Hit N/A —
996 PA3590 3-hydroxyacyl-CoA dehydrogenase PA3590 AlphaFold –
GO:0008691Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+. GO:0070403Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. GO:0006635A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). +36 total
0.884 Hit 41.7% 8.01e-55
997 PA1810 ABC transporter PA1810 AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. +58 total
0.884 No Hit N/A —
998 PA1361 multidrug resistance protein PmpM norM, PA1361, pmpM AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0098567The leaflet of the plasma membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +58 total
0.884 Hit 27.8% 1.44e-13
999 PA0732 hypothetical protein PA0732 AlphaFold –
GO:0071972Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +25 total
0.884 No Hit N/A —
1000 PA0683 type II secretion system protein PA0683 AlphaFold –
GO:0009276The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. +14 total
0.884 No Hit N/A —
Page of 223 · 5572 total proteins