Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1026 PA0212 malonate decarboxylase subunit gamma PA0212, mdcE Experimental + AlphaFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
0.882 No Hit N/A —
1027 PA0211 malonate decarboxylase subunit beta mdcD, PA0211 Experimental + AlphaFold –
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +14 total
0.882 Hit 28.6% 2.08e-06
1028 PA5458 acyltransferase PA5458 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. +14 total
0.881 No Hit N/A —
1029 PA4844 chemotaxis transducer ctpL, PA4844 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). +47 total
0.881 No Hit N/A —
1030 PA4504 ABC transporter permease PA4504 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.881 No Hit N/A —
1031 PA2786 hypothetical protein PA2786 AlphaFold –
GO:0005515Binding to a protein.
0.881 No Hit N/A —
1032 PA2418 quercetin 2,3-dioxygenase PA2418 AlphaFold
1.13.11.24
GO:0046872Binding to a metal ion. GO:0008127Catalysis of the reaction: H+ + O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO.
0.881 Hit 36.2% 9.29e-42
1033 PA2079 amino acid permease PA2079 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015185Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). GO:0015291Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters. +36 total
0.881 Hit 26.2% 4.70e-12
1034 PA1851 hypothetical protein PA1851 AlphaFold
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species. +14 total
0.881 No Hit N/A —
1035 PA1276 threonine-phosphate decarboxylase cobC, PA1276 AlphaFold
4.1.1.81
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0048472Catalysis of the reaction: O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2. +36 total
0.881 No Hit N/A —
1036 PA0616 hypothetical protein PA0616, VR2 Experimental + AlphaFold – – 0.881 No Hit N/A —
1037 PA5397 hypothetical protein PA5397 AlphaFold –
GO:0042426The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. GO:0031457The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine.
0.88 No Hit N/A —
1038 PA4839 arginine decarboxylase speA, PA4839 AlphaFold
4.1.1.19
GO:0008792Catalysis of the reaction: L-arginine + H+ = agmatine + CO2. GO:0046872Binding to a metal ion. GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. +36 total
0.88 No Hit N/A —
1039 PA4178 hypothetical protein PA4178 AlphaFold –
GO:0008425Catalysis of the reaction: a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-homocysteine + H+. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0017000The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. +25 total
0.88 No Hit N/A —
1040 PA3547 alginate lyase algL, PA3547 Experimental + AlphaFold
4.2.2.3
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0045135Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. GO:0004794Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4. +36 total
0.88 No Hit N/A —
1041 PA2651 hypothetical protein PA2651 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.88 No Hit N/A —
1042 PA1910 ferric-mycobactin receptor FemA femA, PA1910 Experimental + AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0015344Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). +710 total
0.88 No Hit N/A —
1043 PA1748 enoyl-CoA hydratase PA1748 AlphaFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006635A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
0.88 Hit 28.6% 8.94e-17
1044 PA1237 multidrug resistance efflux pump PA1237 AlphaFold – – 0.88 No Hit N/A —
1045 PA1054 monovalent cation/H+ antiporter subunit A PA1054 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015385Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). GO:0035725A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
0.88 Hit 33.1% 2.78e-48
1046 PA5296 ATP-dependent DNA helicase Rep rep, PA5296 AlphaFold
5.6.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043138Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +811 total
0.879 No Hit N/A —
1047 PA5215 glycine cleavage system aminomethyltransferase T gcvT1 ColabFold –
GO:0006546The chemical reactions and pathways resulting in the breakdown of glycine. GO:0004047Catalysis of the reaction: N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4+. GO:0005515Binding to a protein.
0.879 Hit 39.4% 2.44e-25
1048 PA5027 hypothetical protein PA5027 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006950Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
0.879 No Hit N/A —
1049 PA4734 hypothetical protein PA4734 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.879 No Hit N/A —
1050 PA4062 hypothetical protein PA4062 AlphaFold – – 0.879 No Hit N/A —
Page of 223 · 5572 total proteins