Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1376 PA1876 ABC transporter ATP-binding protein/permease PA1876 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +69 total
0.854 Hit 52.5% 2.43e-06
1377 PA1581 succinate dehydrogenase subunit C sdhC, PA1581 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0046872Binding to a metal ion. +58 total
0.854 Hit 31.4% 7.58e-06
1378 PA1163 glycosyl transferase PA1163, ndvB AlphaFold
2.4.1.336
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +36 total
0.854 No Hit N/A —
1379 PA0238 hypothetical protein PA0238 AlphaFold – – 0.854 No Hit N/A —
1380 PA3831 leucyl aminopeptidase PA3831, phpA, pepA AlphaFold
3.4.11.1 3.4.11.10
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004177Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. GO:0030145Binding to a manganese ion (Mn). +58 total
0.853 Hit 40.3% 7.40e-26
1381 PA3508 transcriptional regulator PA3508 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.853 No Hit N/A —
1382 PA3447 ABC transporter ATP-binding protein ssuB2, PA3447 AlphaFold
7.6.2.14
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.853 Hit 35.5% 1.20e-18
1383 PA3086 hypothetical protein PA3086 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
0.853 No Hit N/A —
1384 PA2382 L-lactate dehydrogenase lldA, PA2382 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0004459Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. +25 total
0.853 Hit 35.7% 1.17e-78
1385 PA1660 hypothetical protein PA1660 AlphaFold –
GO:0033103The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
0.853 No Hit N/A —
1386 PA4725 two-component sensor CbrA PA4725, cbrA AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +1013 total
0.852 No Hit N/A —
1387 PA4167 2,5-diketo-D-gluconate reductase B PA4167 AlphaFold –
GO:1990002Catalysis of the reaction: hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH. GO:0051596The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.852 Hit 44.1% 1.68e-22
1388 PA4154 hypothetical protein PA4154 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.852 No Hit N/A —
1389 PA3788 hypothetical protein PA3788 AlphaFold – – 0.852 No Hit N/A —
1390 PA1891 hypothetical protein PA1891 AlphaFold – – 0.852 No Hit N/A —
1391 PA1855 hypothetical protein PA1855 AlphaFold – – 0.852 No Hit N/A —
1392 PA1729 hypothetical protein PA1729 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.852 No Hit N/A —
1393 PA1685 enolase-phosphatase masA ColabFold –
GO:0000287Binding to a magnesium (Mg) ion. GO:0019509OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. GO:0043874Catalysis of the reactions:5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate.
0.852 Hit 41.4% 8.42e-36
1394 PA1125 NAD-dependent protein deacylase PA1125, cobB1 AlphaFold
2.3.1.286
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0017136Catalysis of the reaction: N(6)-acetyl-L-lysyl-[histone] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a histone to NAD, producing nicotinamide. GO:0070403Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. +36 total
0.852 Hit 45.2% 2.15e-28
1395 PA0984 colicin immunity protein PA0984 AlphaFold –
GO:0015643Binding to a toxic substance, a poisonous substance that causes damage to biological systems. GO:0030153A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.
0.852 No Hit N/A —
1396 PA0393 pyrroline-5-carboxylate reductase proC, PA0393 AlphaFold
1.5.1.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004735Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. GO:0055129The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. +14 total
0.852 Hit 45.6% 2.96e-13
1397 PA0172 hypothetical protein PA0172 Experimental + AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0046872Binding to a metal ion. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. +14 total
0.852 No Hit N/A —
1398 PA5560 ATP synthase subunit A PA5560, atpB AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045259A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. GO:0046933Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + phosphate + 5 H+(out) => ATP + H2O + 4 H+(in). +47 total
0.851 No Hit N/A —
1399 PA4155 hypothetical protein PA4155 AlphaFold –
GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
0.851 No Hit N/A —
1400 PA3558 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF PA3558, arnF AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1901505Enables the transfer of carbohydrate derivative from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +47 total
0.851 No Hit N/A —
Page of 223 · 5572 total proteins