Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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701 / 5572 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
176 PA1119 hypothetical protein PA1119, yfiB Experimental + AlphaFold DB model –
GO:0120101A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0071973Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. +14 total
No map 0.834 No Hit N/A —
177 PA1097 transcriptional regulator FleQ PA1097, fleQ Experimental + AlphaFold DB model –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. +1417 total
No map 0.834 No Hit N/A —
178 PA4006 nicotinic acid mononucleotide adenylyltransferase PA4006, nadD Experimental + AlphaFold DB model
2.7.7.18
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000309Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + ATP + H+ = diphosphate + NAD+. GO:0004515Catalysis of the reaction: nicotinate beta-D-ribonucleotide + ATP + H+ = deamido-NAD+ + diphosphate. +47 total
No map 0.833 Hit 58.8% 4.30e-06
179 PA1610 3-hydroxydecanoyl-ACP dehydratase PA1610, fabA Experimental + AlphaFold DB model
4.2.1.59 5.3.3.14
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019171Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O. GO:0034017Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]. +47 total
No map 0.833 No Hit N/A —
180 PA4137 porin PA4137 Experimental + AlphaFold DB model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
No map 0.832 No Hit N/A —
181 PA4081 fimbrial subunit CupB6 PA4081, cupB6 Experimental + AlphaFold DB model –
GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species. GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
No map 0.832 No Hit N/A —
182 PA4183 hypothetical protein PA4183 Experimental + AlphaFold DB model – – No map 0.831 No Hit N/A —
183 PA4221 Fe(III)-pyochelin outer membrane receptor fptA, PA4221 Experimental + AlphaFold DB model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:1903981Binding to enterobactin. GO:0015344Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). +47 total
No map 0.83 No Hit N/A —
184 PA2939 aminopeptidase lap, PA2939 Experimental + AlphaFold DB model
3.4.11.1
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0004177Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. GO:0046872Binding to a metal ion. +47 total
No map 0.83 Hit 35.9% 4.80e-06
185 PA1314 hypothetical protein PA1314 Experimental + AlphaFold DB model – – No map 0.83 No Hit N/A —
186 PA4079 short-chain dehydrogenase PA4079 Experimental + AlphaFold DB model –
GO:0004090Catalysis of the reaction: a secondary alcohol + NADP+ = a ketone + H+ + NADPH. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
No map 0.827 No Hit N/A —
187 PA1712 exoenzyme S synthesis protein ExsB PA1712, exsB Experimental + AlphaFold DB model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
No map 0.827 No Hit N/A —
188 PA3005 beta-hexosaminidase PA3005, nagZ Experimental + AlphaFold DB model
3.2.1.52
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016231Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +811 total
No map 0.825 No Hit N/A —
189 PA5516 pyridoxamine kinase PA5516, pdxY Experimental + AlphaFold DB model
2.7.1.35
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000287Binding to a magnesium (Mg) ion. +25 total
No map 0.824 Hit 50.0% 3.11e-09
190 PA0510 uroporphyrin-III C-methyltransferase nirE, PA0510, cobA, cysG_1 Experimental + AlphaFold DB model
2.1.1.107
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +69 total
No map 0.824 No Hit N/A —
191 PA3645 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ fabZ, PA3645 Experimental + AlphaFold DB model
4.2.1.59
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0019171Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O. +36 total
No map 0.822 No Hit N/A —
192 PA2788 chemotaxis transducer PA2788, mcpN Experimental + AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. +14 total
No map 0.822 No Hit N/A —
193 PA1984 NAD+ dependent aldehyde dehydrogenase ExaC exaC, PA1984 Experimental + AlphaFold DB model –
GO:0004030Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
No map 0.822 Hit 45.5% 3.24e-08
194 PA3479 rhamnosyltransferase subunit A PA3479, rhlA Experimental + AlphaFold DB model
2.3.1.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0090499Catalysis of the reaction: 6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H+ + methanol. +25 total
No map 0.821 No Hit N/A —
195 PA3499 hypothetical protein PA3499 Experimental + AlphaFold DB model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
No map 0.819 No Hit N/A —
196 PA0572 hypothetical protein PA0572, impA Experimental + AlphaFold DB model
3.4.24.-
GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0046872Binding to a metal ion. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +58 total
No map 0.819 No Hit N/A —
197 PA4872 hypothetical protein PA4872 Experimental + AlphaFold DB model
4.1.1.112
GO:0000287Binding to a magnesium (Mg) ion. GO:0046421Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. GO:0008948Catalysis of the reaction: H+ + oxaloacetate = CO2 + pyruvate. +47 total
No map 0.818 No Hit N/A —
198 PA0577 DNA primase PA0577, dnaG Experimental + AlphaFold DB model
2.7.7.101
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000428A protein complex that possesses DNA-directed RNA polymerase activity. GO:1990077Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. +710 total
No map 0.818 No Hit N/A —
199 PA0762 RNA polymerase sigma factor AlgU algU, algT, PA0762 Experimental + AlphaFold DB model –
GO:0000345The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. +1619 total
No map 0.817 No Hit N/A —
200 PA0254 hypothetical protein hudA, PA0254 Experimental + AlphaFold DB model
4.1.1.93
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008694Catalysis of the reaction: a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + H+ = a 2-(all-trans-polyprenyl)phenol + CO2. +47 total
No map 0.817 No Hit N/A —
Page of 29 · 701 total proteins