Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2226 PA2035 thiamine pyrophosphate protein PA2035 AlphaFold –
GO:0005948A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate. GO:0003984Catalysis of the reaction: H+ + 2 pyruvate = (2S)-2-acetolactate + CO2. Can also convert 2-oxobutanoate and pyruvate to (S)-2-ethyl-2-hydroxy-3-oxobutanoate. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +58 total
0.781 Hit 36.1% 1.99e-14
2227 PA1941 hypothetical protein PA1941 AlphaFold –
GO:0004130Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +14 total
0.781 No Hit N/A —
2228 PA1111 hypothetical protein PA1111 AlphaFold – – 0.781 No Hit N/A —
2229 PA0658 short-chain dehydrogenase PA0658 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.781 Hit 37.6% 1.05e-09
2230 PA5429 aspartate ammonia-lyase PA5429, aspA AlphaFold
4.3.1.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008797Catalysis of the reaction: L-aspartate = fumarate + NH4+. GO:0045548Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate. +47 total
0.78 Hit 42.3% 1.54e-106
2231 PA4903 major facilitator superfamily transporter PA4903 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046943Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). GO:0046942The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). +36 total
0.78 Hit 37.4% 1.87e-06
2232 PA3683 hypothetical protein PA3683 AlphaFold – – 0.78 No Hit N/A —
2233 PA3490 electron transport complex subunit B rnfB, PA3490 AlphaFold
7.-.-.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. +36 total
0.78 No Hit N/A —
2234 PA1733 hypothetical protein PA1733 AlphaFold –
GO:0005839A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. GO:0051603OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
0.78 No Hit N/A —
2235 PA1596 chaperone protein HtpG htpG, PA1596 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +58 total
0.78 Hit 67.6% 2.51e-10
2236 PA1514 ureidoglycolate hydrolase PA1514, allA AlphaFold
4.3.2.3
GO:0004848Catalysis of the reaction: (S)-ureidoglycolate + H2O + 2 H+ = CO2 + glyoxylate + 2 NH4. GO:0050385Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea. GO:0000256The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. +14 total
0.78 No Hit N/A —
2237 PA1233 hypothetical protein PA1233 AlphaFold – – 0.78 No Hit N/A —
2238 PA0839 transcriptional regulator PA0839 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
0.78 No Hit N/A —
2239 PA0277 hypothetical protein PA0277 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0046872Binding to a metal ion. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +25 total
0.78 No Hit N/A —
2240 PA0268 transcriptional regulator PA0268 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +36 total
0.78 Hit 28.1% 1.96e-06
2241 PA4914 transcriptional regulator PA4914 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +36 total
0.779 No Hit N/A —
2242 PA4061 thioredoxin PA4061 AlphaFold –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. GO:0006950Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). +14 total
0.779 Hit 41.2% 3.14e-12
2243 PA3670 hypothetical protein PA3670 AlphaFold – – 0.779 No Hit N/A —
2244 PA3207 hypothetical protein PA3207 AlphaFold – – 0.779 No Hit N/A —
2245 PA2764 hypothetical protein PA2764 AlphaFold – – 0.779 No Hit N/A —
2246 PA0286 delta-9 fatty acid desaturase DesA desA, PA0286 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016717Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. +14 total
0.779 No Hit N/A —
2247 PA0115 hypothetical protein PA0115 Experimental + AlphaFold –
GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.779 No Hit N/A —
2248 PA5528 hypothetical protein PA5528 AlphaFold – – 0.778 No Hit N/A —
2249 PA5476 citrate transporter citA, PA5476 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +36 total
0.778 No Hit N/A —
2250 PA5299 hypothetical protein PA5299 AlphaFold –
GO:0008775Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. GO:0006083The chemical reactions and pathways involving acetate, the anion of acetic acid.
0.778 No Hit N/A —
Page of 223 · 5572 total proteins