Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2201 PA1545 hypothetical protein PA1545 AlphaFold – – 0.783 No Hit N/A —
2202 PA1373 3-oxoacyl-ACP synthase fabF2, PA1373 AlphaFold
2.3.1.179
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +25 total
0.783 Hit 44.8% 8.03e-112
2203 PA1000 thioesterase PqsE pqsE, PA1000 Experimental + AlphaFold
3.1.2.32
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0044550The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
0.783 No Hit N/A —
2204 PA5259 uroporphyrinogen-III synthase PA5259, hemD Experimental + AlphaFold
4.2.1.75
GO:0004852Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III. GO:0006782The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. GO:0006780The chemical reactions and pathways resulting in the formation of uroporphyrinogen III. +14 total
0.782 No Hit N/A —
2205 PA5188 3-hydroxyacyl-CoA dehydrogenase PA5188 AlphaFold –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0070403Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. +36 total
0.782 Hit 40.3% 2.38e-99
2206 PA4591 hypothetical protein PA4591 AlphaFold –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.
0.782 No Hit N/A —
2207 PA4324 hypothetical protein PA4324 AlphaFold –
GO:0035438Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
0.782 No Hit N/A —
2208 PA4217 hypothetical protein phzS, PA4217 Experimental + AlphaFold
1.14.13.218
GO:0102169Catalysis of the reaction: 5-methyl-phenazine-1-carboxylate + 2 H+ + NADH + O2 = CO2 + H2O + NAD+ + pyocyanin. Also converts phenazine-1-carboxylate into 1-hydroxyphenazine. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
0.782 No Hit N/A —
2209 PA4002 rod shape-determining protein mrdB, rodA, PA4002 AlphaFold
2.4.99.28
GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015648Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells. +69 total
0.782 No Hit N/A —
2210 PA3409 transmembrane sensor PA3409 AlphaFold –
GO:0016989The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.
0.782 No Hit N/A —
2211 PA2903 precorrin-3 methylase CobJ PA2903, cobJ AlphaFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0032259The process in which a methyl group is covalently attached to a molecule.
0.782 No Hit N/A —
2212 PA2381 hypothetical protein PA2381 AlphaFold – – 0.782 No Hit N/A —
2213 PA0836 acetate kinase ackA, PA0836 AlphaFold
2.7.2.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008776Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +710 total
0.782 No Hit N/A —
2214 PA0054 RNA 2'-phosphotransferase-like protein kptA, PA0054 AlphaFold
2.7.1.-
GO:0003950Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. GO:0000215Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. +25 total
0.782 Hit 40.0% 7.43e-06
2215 PA5202 hypothetical protein PA5202 Experimental + AlphaFold –
GO:0016289Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+. GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
0.781 No Hit N/A —
2216 PA4729 3-methyl-2-oxobutanoate hydroxymethyltransferase panB ColabFold –
GO:0015940The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0003864Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate.
0.781 No Hit N/A —
2217 PA4152 branched-chain alpha-keto acid dehydrogenase subunit E2 PA4152 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.781 Hit 35.6% 1.60e-07
2218 PA3845 transcriptional regulator PA3845 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +25 total
0.781 No Hit N/A —
2219 PA3608 polyamine ABC transporter permease PotB PA3608, potB AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015417Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in). GO:1903711The process in which spermidine is transported across a membrane. +25 total
0.781 No Hit N/A —
2220 PA3469 hypothetical protein PA3469 AlphaFold –
GO:0008703Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + H+ + NADPH. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
0.781 No Hit N/A —
2221 PA3045 two-component response regulator PA3045 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0051051Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.781 No Hit N/A —
2222 PA3002 transcription-repair coupling factor PA3002, mfd AlphaFold
3.6.4.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003684Binding to damaged DNA. +912 total
0.781 Hit 30.5% 1.07e-06
2223 PA2597 hypothetical protein PA2597 AlphaFold –
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
0.781 Hit 33.0% 3.26e-08
2224 PA2592 spermidine/putrescine-binding protein PA2592 AlphaFold –
GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0019810Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. +58 total
0.781 No Hit N/A —
2225 PA2425 pyoverdine biosynthesis protein PvdG PA2425, pvdG AlphaFold –
GO:0008610The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0002049The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
0.781 Hit 33.9% 1.70e-16
Page of 223 · 5572 total proteins