Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4226 VK055_1887 parB-like nuclease domain protein AlphaFold + ColabFold –
GO:0071453Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
0.261 No Hit 0.0% —
4227 VK055_1358 glycine-zipper containing OmpA-like membrane domain protein AlphaFold + ColabFold –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
0.261 No Hit 0.0% —
4228 VK055_1214 acyl-CoA thioesterase yciA AlphaFold + ColabFold –
GO:0016790Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0052816Catalysis of the reaction: a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. +25 total
0.261 Hit 31.0% 1.42e-09
4229 VK055_0643 hypothetical protein AlphaFold + ColabFold – – 0.261 No Hit 0.0% —
4230 VK055_3772 ribosomal protein S5 rpsE AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0015935The smaller of the two subunits of a ribosome. GO:0003723Binding to an RNA molecule or a portion thereof. +25 total
0.26 Hit 29.2% 4.60e-08
4231 VK055_2684 ribosyldihydronicotinamide dehydrogenase (quinone) nqo2 Experimental + ColabFold – – 0.26 Hit 51.9% 1.59e-10
4232 VK055_2109 hypothetical protein AlphaFold + ColabFold – – 0.26 No Hit 0.0% —
4233 VK055_2469 preprotein translocase, SecA subunit secA AlphaFold + ColabFold
7.4.2.8
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0017038The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. +912 total
0.259 No Hit 0.0% —
4234 VK055_0589 helix-turn-helix family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.259 No Hit 0.0% —
4235 VK055_0582 bacterial extracellular solute-binding, 3 familyprotein AlphaFold + ColabFold – – 0.259 No Hit 0.0% —
4236 VK055_3060 bacterial transferase hexapeptide family protein AlphaFold + ColabFold – – 0.258 No Hit 0.0% —
4237 VK055_2985 molybdopterin oxidoreductase family protein AlphaFold + ColabFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.258 No Hit 0.0% —
4238 VK055_2421 2'-5' RNA ligase AlphaFold + ColabFold
3.1.4.58
GO:0008664Catalysis the reaction: a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H+. GO:0004113Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. GO:0016874Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
0.258 No Hit 0.0% —
4239 VK055_2139 GlnK glnK AlphaFold + ColabFold –
GO:0006808Any process that modulates the frequency, rate or extent of nitrogen utilization. GO:0030234A molecular function regulator that modulates a catalytic activity. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.258 No Hit 0.0% —
4240 VK055_1470 glycerol dehydratase dhaB1 AlphaFold + ColabFold
2.3.1.54 4.1.1.83
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043722Catalysis of the reaction: (4-hydroxyphenyl)acetate + H+ = 4-cresol + CO2. +14 total
0.258 No Hit 0.0% —
4241 VK055_4403 cysN cysN AlphaFold + ColabFold
2.7.7.4
GO:0005525Binding to GTP, guanosine triphosphate. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0006790The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. +47 total
0.257 Hit 37.1% 2.19e-28
4242 VK055_2316 gpt gpt AlphaFold + ColabFold
2.4.2.22
GO:0000310Catalysis of the reaction: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
0.257 No Hit 0.0% —
4243 VK055_1104 type VI secretion system protein impJ AlphaFold + ColabFold – – 0.257 No Hit 0.0% —
4244 VK055_5057 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT2 AlphaFold + ColabFold
2.4.2.21
GO:0008939Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
0.256 No Hit 0.0% —
4245 VK055_4775 protein mrkE mrkE AlphaFold + ColabFold –
GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +14 total
0.256 No Hit 0.0% —
4246 VK055_3759 30S ribosomal subunit protein S19 rpsS ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +14 total
0.256 No Hit 0.0% —
4247 VK055_4548 agmatinase speB2 AlphaFold + ColabFold
3.5.3.7
GO:0016813Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. GO:0046872Binding to a metal ion. GO:0008783Catalysis of the reaction: agmatine + H2O = putrescine + urea. +25 total
0.255 Hit 61.0% 1.05e-134
4248 VK055_2175 nucleotide binding protein yajQ AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.255 No Hit 0.0% —
4249 VK055_3286 PIN domain protein AlphaFold + ColabFold –
GO:0004540Catalysis of the cleavage of phosphodiester bonds in chains of RNA.
0.254 No Hit 0.0% —
4250 VK055_1415 putative cysteine hydrolase predicted hydrolase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.254 Hit 28.9% 4.41e-06
Page of 204 · 5081 total proteins