Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 / 5081 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4226 VK055_4559 rnfH Ubiquitin family protein AlphaFold DB model + ColabFold model – – No map N/A 0.121 No Hit 0.0% —
4227 VK055_4204 crcB-like family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0062054Enables the energy-independent facilitated diffusion of a fluoride ion through a transmembrane aqueous pore or channel. +25 total
No map 0.121 0.733 No Hit 0.0% —
4228 VK055_5154 hypothetical protein ColabFold model – – No map N/A 0.12 No Hit 0.0% —
4229 VK055_4483 putative adhesin Experimental + ColabFold model –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0046872Binding to a metal ion. +14 total
No map 0.120 0.193 No Hit 0.0% —
4230 VK055_3464 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.120 0.315 No Hit 0.0% —
4231 VK055_2970 carbon-phosphorous lyase complex subunit AlphaFold DB model + ColabFold model –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0019700The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.
Chokepoint 2 0.120 0.282 No Hit 0.0% —
4232 VK055_2064 S4 domain protein AlphaFold DB model + ColabFold model –
GO:0003723Binding to an RNA molecule or a portion thereof.
No map N/A 0.12 No Hit 0.0% —
4233 VK055_0559 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.12 No Hit 0.0% —
4234 VK055_0463 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.120 0.446 No Hit 0.0% —
4235 VK055_0415 3-oxoacid CoA-transferase, A subunit AlphaFold DB model + ColabFold model –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
Chokepoint 2 0.120 0.676 Hit 60.0% 8.31e-33
4236 VK055_4512 nrdI protein nrdI AlphaFold DB model + ColabFold model –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
No map 0.119 0.67 No Hit 0.0% —
4237 VK055_1004 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.119 0.279 No Hit 0.0% —
4238 VK055_0008 GDSL-like Lipase/Acylhydrolase family protein AlphaFold DB model + ColabFold model –
GO:0016788Catalysis of the hydrolysis of any ester bond.
No map 0.119 0.299 No Hit 0.0% —
4239 VK055_4825 phosphodiesterase, MJ0936 family protein AlphaFold DB model + ColabFold model
3.1.4.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
No map 0.118 0.105 No Hit 0.0% —
4240 VK055_2468 8-oxo-dGTPase mutT Experimental + ColabFold model
3.6.1.55
GO:0008413Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +58 total
Chokepoint 2 0.118 0.417 No Hit 0.0% —
4241 VK055_1627 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.118 0.552 No Hit 0.0% —
4242 VK055_1517 ssuC ycbM AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.118 0.709 No Hit 0.0% —
4243 VK055_3615 nickel-responsive transcriptional regulator NikR nikR AlphaFold DB model + ColabFold model –
GO:0010045Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus. GO:0016151Binding to a nickel (Ni) cation. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
No map 0.117 0.272 No Hit 0.0% —
4244 VK055_5178 hypothetical protein ColabFold model – – No map N/A 0.116 No Hit 0.0% —
4245 VK055_4661 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.116 No Hit 0.0% —
4246 VK055_2693 ABC-2 type transporter family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
No map 0.116 0.763 No Hit 0.0% —
4247 VK055_1761 molybdenum-pterin binding domain protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0030151Binding to a molybdenum ion (Mo). GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. +25 total
No map N/A 0.116 No Hit 0.0% —
4248 VK055_1323 adenylosuccinate lyase purB AlphaFold DB model + ColabFold model
4.3.2.2
GO:0006188The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004018Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. +58 total
Chokepoint 4 0.116 0.248 Hit 23.2% 5.01e-07
4249 VK055_4510 ribonucleoside-diphosphate reductase subunit beta nrdF2 nrdF2 AlphaFold DB model + ColabFold model
1.17.4.1
GO:0005971An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor. GO:0009263The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +25 total
Mapped 8 0.115 0.548 Hit 22.0% 5.93e-07
4250 VK055_1332 potC potC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.115 0.482 No Hit 0.0% —
Page of 204 · 5081 total proteins