Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2826 KP13_02304 Aldehyde dehydrogenase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
No map 0.719 No Hit 0.0% —
2827 KP13_02308 putative propanediol utilization protein AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.005 No Hit 0.0% —
2828 KP13_02309 putative propanediol utilization protein AlphaFold DB model + ColabFold model –
GO:0005198The action of a molecule that contributes to the structural integrity of a complex.
No map 0.66 No Hit 0.0% —
2829 KP13_02310 Phosphate propanoyltransferase pduL AlphaFold DB model + ColabFold model
2.3.1.222
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy. GO:0046872Binding to a metal ion. +14 total
No map 0.733 No Hit 0.0% —
2830 KP13_02311 putative propanediol utilization protein AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.247 No Hit 0.0% —
2831 KP13_02312 Propanediol utilization protein pduA pduA AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.512 No Hit 0.0% —
2832 KP13_02313 Propanediol utilization protein PduH pduH AlphaFold DB model + ColabFold model – – No map 0.136 No Hit 0.0% —
2833 KP13_02314 Diol dehydratase-reactivating factor alpha subunit ddrA AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion.
No map 0.638 No Hit 0.0% —
2834 KP13_02315 Propanediol dehydratase small subunit pduE AlphaFold DB model + ColabFold model – – No map 0.604 No Hit 0.0% —
2835 KP13_02316 Propanediol dehydratase medium subunit pduD AlphaFold DB model + ColabFold model – – No map 0.754 No Hit 0.0% —
2836 KP13_02317 Propanediol dehydratase large subunit pduC AlphaFold DB model + ColabFold model –
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0031419Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
No map 0.451 No Hit 0.0% —
2837 KP13_02323 hypothetical protein ColabFold model – – No map 0.748 No Hit 0.0% —
2838 KP13_02324 Cobyrinic acid A,C-diamide synthase cbiA AlphaFold DB model + ColabFold model
6.3.5.11
GO:0042242Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
No map 0.906 No Hit 0.0% —
2839 KP13_02325 Cobalamin biosynthesis protein cobD AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0048472Catalysis of the reaction: O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2. +25 total
No map 0.865 No Hit 0.0% —
2840 KP13_02326 Cobalt-precorrin-8X methylmutase cbiC AlphaFold DB model + ColabFold model –
GO:0016993Catalysis of the reaction: precorrin-8X = hydrogenobyrinate. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
No map 0.374 No Hit 0.0% —
2841 KP13_02327 Putative cobalt-precorrin-6A synthase cbiD AlphaFold DB model + ColabFold model
2.1.1.195
GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0043780Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A. +25 total
No map 0.142 No Hit 0.0% —
2842 KP13_02329 putative cobalt-precorrin-6Y C(15)-methyltransferase cbiT AlphaFold DB model + ColabFold model –
GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +14 total
No map 0.386 No Hit 0.0% —
2843 KP13_02331 Protein cbiG cbiG AlphaFold DB model + ColabFold model –
GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
No map 0.926 No Hit 0.0% —
2844 KP13_02332 Cobalt-precorrin-3B C(17)-methyltransferase cbiH AlphaFold DB model + ColabFold model –
GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
No map 0.27 No Hit 0.0% —
2845 KP13_02333 Cobalt-precorrin-6A reductase cbiJ AlphaFold DB model + ColabFold model –
GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0016994Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+.
No map 0.55 No Hit 0.0% —
2846 KP13_02334 Sirohydrochlorin cobaltochelatase cbiK AlphaFold DB model + ColabFold model
4.99.1.3
GO:0019251The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen. GO:0016852Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+. GO:0046872Binding to a metal ion.
No map 0.61 No Hit 0.0% —
2847 KP13_02335 Cobalt-precorrin-2 C(20)-methyltransferase cbiL AlphaFold DB model + ColabFold model –
GO:0030788Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H+ + precorrin-3A. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0008757Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. +25 total
No map 0.742 No Hit 0.0% —
2848 KP13_02336 Protein cbiM cbiM AlphaFold DB model + ColabFold model –
GO:0000041The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006824The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
No map 0.651 No Hit 0.0% —
2849 KP13_02337 Cobalt transport protein cbiN cbiN AlphaFold DB model + ColabFold model –
GO:0006824The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015087Enables the transfer of cobalt (Co2+) ions from one side of a membrane to the other. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +25 total
No map 0.352 No Hit 0.0% —
2850 KP13_02338 Cobalt transport protein CbiQ cbiQ AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006824The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
No map 0.409 No Hit 0.0% —
Page of 234 · 5842 total proteins