Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
301 KP13_05252 Putative type VI secretion system effector, Hcp1 family ColabFold model – – No map 0.107 No Hit 0.0% —
302 KP13_00793 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.108 No Hit 0.0% —
303 KP13_03574 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.108 No Hit 0.0% —
304 KP13_05606 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.108 No Hit 0.0% —
305 KP13_01027 USG-1 protein usg AlphaFold DB model + ColabFold model –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0046983The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. +14 total
No map 0.109 No Hit 0.0% —
306 KP13_02712 FAD-dependent pyridine nucleotide-disulfide oxidoreductase family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.109 Hit 26.6% 1.22e-29
307 KP13_03905 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.109 No Hit 0.0% —
308 KP13_04521 Benzoate 1,2-dioxygenase subunit beta AlphaFold DB model + ColabFold model –
GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0019380The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid.
No map 0.109 No Hit 0.0% —
309 KP13_05333 Putative iron compound ABC transport system periplasmic binding component AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1901678The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.109 No Hit 0.0% —
310 KP13_00182 HTH-type protein slmA slmA Experimental + ColabFold model –
GO:0010974Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.11 No Hit 0.0% —
311 KP13_01187 Transcriptional regulatory protein dcuR dcuR AlphaFold DB model + ColabFold model –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.11 No Hit 0.0% —
312 KP13_16605 Modification methylase EcoRII AlphaFold DB model + ColabFold model
2.1.1.37
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0003886Catalysis of the reaction: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H+ + S-adenosyl-L-homocysteine. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
No map 0.11 Hit 23.8% 4.05e-07
313 KP13_32060 DNA-binding plasmid partition protein KorB AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.11 No Hit 0.0% —
314 KP13_00478 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.111 No Hit 0.0% —
315 KP13_02815 Urease subunit beta ureB Experimental + ColabFold model
3.5.1.5
GO:0043419The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2. GO:0035550A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide). GO:0009039Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+.
No map 0.111 No Hit 0.0% —
316 KP13_05310 Cytochrome c biogenesis ATP-binding export protein CcmA ccmA AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +14 total
No map 0.111 Hit 33.5% 2.27e-12
317 KP13_03157 putative oligopeptide/dipeptide ABC transporter AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.112 Hit 42.9% 8.35e-06
318 KP13_03316 Protein nagD nagD AlphaFold DB model + ColabFold model
3.1.3.5
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008253Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. GO:0046872Binding to a metal ion.
No map 0.112 Hit 41.3% 3.13e-12
319 KP13_32220 Osmotically-inducible protein Y osmY AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.112 No Hit 0.0% —
320 KP13_01185 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.113 No Hit 0.0% —
321 KP13_01923 3-isopropylmalate dehydratase large subunit leuC AlphaFold DB model + ColabFold model
4.2.1.33
GO:0003861Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0009098The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid. +25 total
No map 0.113 Hit 26.8% 2.05e-23
322 KP13_03356 Alkyl hydroperoxide reductase subunit F ahpF AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008785Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +69 total
No map 0.113 No Hit 0.0% —
323 KP13_04179 putative transposase AlphaFold DB model + ColabFold model – – No map 0.113 No Hit 0.0% —
324 KP13_04494 putative acyltransferase AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.113 No Hit 0.0% —
325 KP13_32185 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.113 No Hit 0.0% —
Page of 234 · 5842 total proteins