Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 / 5842 proteins

Scoring formula None

Sorted by Druggability (ascending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
376 KP13_02755 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.131 No Hit 0.0% —
377 KP13_03267 Protein tolR tolR AlphaFold DB model + ColabFold model –
GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +36 total
No map 0.131 No Hit 0.0% —
378 KP13_04519 Catechol 1,2-dioxygenase AlphaFold DB model + ColabFold model
1.13.11.1
GO:0016702Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. GO:0009712The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. +69 total
No map 0.131 No Hit 0.0% —
379 KP13_03400 hypothetical protein ColabFold model – – No map 0.132 No Hit 0.0% —
380 KP13_04322 putative transketolase family protein AlphaFold DB model + ColabFold model
2.2.1.7
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008661Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2.
No map 0.132 Hit 35.3% 9.40e-24
381 KP13_04354 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.132 No Hit 0.0% —
382 KP13_04674 50S ribosomal protein L20 rplT AlphaFold DB model + ColabFold model –
GO:0019843Binding to a ribosomal RNA. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +14 total
No map 0.132 Hit 40.4% 1.69e-07
383 KP13_05276 Multiple antibiotic resistance protein marA marA AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.132 No Hit 0.0% —
384 KP13_06667 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.132 No Hit 0.0% —
385 KP13_31874 putative cobalt-precorrin-6Y C(5)-methyltransferase cbiE AlphaFold DB model + ColabFold model –
GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +14 total
No map 0.132 No Hit 0.0% —
386 KP13_32012 hypothetical protein ColabFold model – – No map 0.132 No Hit 0.0% —
387 KP13_01848 Type 4 prepilin-like proteins leader peptide-processing enzyme bifunctional protein pulO AlphaFold DB model + ColabFold model
2.1.1.- 3.4.23.43
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004190Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
No map 0.133 No Hit 0.0% —
388 KP13_02855 Autoinducer 2-degrading protein lsrG lsrG AlphaFold DB model + ColabFold model
5.3.1.32
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0002952Catalysis of the reaction: (2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.133 No Hit 0.0% —
389 KP13_02973 HTH-type transcriptional activator aaeR aaeR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.133 No Hit 0.0% —
390 KP13_03393 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.133 No Hit 0.0% —
391 KP13_04297 putative ABC transporter ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.133 Hit 38.7% 4.19e-18
392 KP13_31860 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.133 No Hit 0.0% —
393 KP13_02359 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. +58 total
No map 0.134 No Hit 0.0% —
394 KP13_05475 TIM barrel domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.134 No Hit 0.0% —
395 KP13_00266 Ankyrin repeat domain-containing protein AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein.
No map 0.135 Hit 38.6% 4.07e-06
396 KP13_01881 Pyruvate dehydrogenase complex repressor pdhR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.135 No Hit 0.0% —
397 KP13_02195 Tyrosine recombinase xerD xerD AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0009009Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences. +69 total
No map 0.135 No Hit 0.0% —
398 KP13_02636 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.135 No Hit 0.0% —
399 KP13_01153 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.136 No Hit 0.0% —
400 KP13_01755 ATPase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046872Binding to a metal ion.
No map 0.136 No Hit 0.0% —
Page of 234 · 5842 total proteins