Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4426 KP13_04670 hypothetical protein AlphaFold + ColabFold – – No map 0.13 No Hit 0.0% —
4427 KP13_04671 Integration host factor subunit alpha ihfA AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.673 No Hit 0.0% —
4428 KP13_04675 50S ribosomal protein L35 rpmI AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
No map 0.477 No Hit 0.0% —
4429 KP13_04676 Translation initiation factor IF-3 infC AlphaFold + ColabFold –
GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. GO:0006413The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No map 0.351 No Hit 0.0% —
4430 KP13_04679 hypothetical protein AlphaFold + ColabFold – – No map 0.49 No Hit 0.0% —
4431 KP13_04680 putative salt-induced outer membrane protein AlphaFold + ColabFold – – No map 0.724 No Hit 0.0% —
4432 KP13_04681 6-phosphofructokinase isozyme 2 pfkB AlphaFold + ColabFold –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +36 total
No map 0.925 No Hit 0.0% —
4433 KP13_04682 hypothetical protein AlphaFold + ColabFold –
GO:0004521Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.
No map 0.291 No Hit 0.0% —
4434 KP13_04684 Protein tonB tonB AlphaFold + ColabFold –
GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
No map 0.038 No Hit 0.0% —
4435 KP13_04685 hypothetical protein AlphaFold + ColabFold – – No map 0.388 No Hit 0.0% —
4436 KP13_04686 hypothetical protein ColabFold – – No map 0.529 No Hit 0.0% —
4437 KP13_04687 YceI-like domain-containing protein AlphaFold + ColabFold – – No map 0.991 No Hit 0.0% —
4438 KP13_04688 hypothetical protein AlphaFold + ColabFold – – No map 0.84 No Hit 0.0% —
4439 KP13_04689 Cardiolipin synthase cls AlphaFold + ColabFold
2.7.8.-
GO:0008808Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. GO:0032049The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. GO:0016780Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). +25 total
No map 0.412 No Hit 0.0% —
4440 KP13_04690 hypothetical protein AlphaFold + ColabFold – – No map 0.373 No Hit 0.0% —
4441 KP13_04694 Oligopeptide transport system permease protein oppC oppC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.74 No Hit 0.0% —
4442 KP13_04695 Oligopeptide transport system permease protein oppB oppB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.642 No Hit 0.0% —
4443 KP13_04696 Periplasmic oligopeptide-binding protein oppA oppA AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +36 total
No map 0.862 No Hit 0.0% —
4444 KP13_04697 hypothetical protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.923 No Hit 0.0% —
4445 KP13_04698 hypothetical protein AlphaFold + ColabFold – – No map 0.407 No Hit 0.0% —
4446 KP13_04700 Thymidine kinase tdk AlphaFold + ColabFold
2.7.1.21
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004797Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No map 0.903 No Hit 0.0% —
4447 KP13_04701 DNA-binding protein H-NS AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +811 total
No map 0.96 No Hit 0.0% —
4448 KP13_04703 Protein hnr hnr AlphaFold + ColabFold –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0097588Cell motility due to movement of bacterial- or archaeal-type flagella. GO:0045862Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. +14 total
No map 0.785 No Hit 0.0% —
4449 KP13_04705 hypothetical protein AlphaFold + ColabFold – – No map 0.635 No Hit 0.0% —
4450 KP13_04707 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043200Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
No map 0.318 No Hit 0.0% —
Page of 234 · 5842 total proteins