Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 / 5842 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4576 KP13_31636 Membrane-bound lytic murein transglycosylase D mltD AlphaFold DB model + ColabFold model
4.2.2.n1
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000270The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008933Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. +36 total
No map 0.164 0.311 No Hit 0.0% —
4577 KP13_06932 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.163 No Hit 0.0% —
4578 KP13_02732 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.163 0.485 No Hit 0.0% —
4579 KP13_01939 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.163 0.833 No Hit 0.0% —
4580 KP13_01008 putative disulfide bond reductase AlphaFold DB model + ColabFold model –
GO:0015036Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
No map 0.163 0.592 No Hit 0.0% —
4581 KP13_00541 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.163 No Hit 0.0% —
4582 KP13_04466 Inner membrane ABC transporter permease protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.162 0.999 No Hit 0.0% —
4583 KP13_04209 Anaerobic dimethyl sulfoxide reductase chain B AlphaFold DB model + ColabFold model –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
No map 0.162 0.528 No Hit 0.0% —
4584 KP13_03909 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.162 No Hit 0.0% —
4585 KP13_03712 Cation efflux system protein cusC cusC AlphaFold DB model + ColabFold model –
GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.162 0.713 No Hit 0.0% —
4586 KP13_03148 Multidrug resistance protein mdtA mdtA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map N/A 0.162 No Hit 0.0% —
4587 KP13_01983 Ubiquinol-cytochrome c chaperone AlphaFold DB model + ColabFold model – – No map 0.162 0.51 No Hit 0.0% —
4588 KP13_01266 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.162 No Hit 0.0% —
4589 KP13_31925 Glutamine-binding periplasmic protein glnH AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015276Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
No map 0.161 0.516 Hit 35.6% 4.48e-07
4590 KP13_04487 L-asparagine permease ansP AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.161 0.278 Hit 23.6% 3.76e-07
4591 KP13_01404 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.161 0.302 No Hit 0.0% —
4592 KP13_04070 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.16 No Hit 0.0% —
4593 KP13_02144 hypothetical protein ColabFold model – – No map 0.160 0.753 No Hit 0.0% —
4594 KP13_02064 Fructose-bisphosphate aldolase fba AlphaFold DB model + ColabFold model –
GO:0030388The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis. GO:0008270Binding to a zinc ion (Zn). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +36 total
No map 0.160 0.946 No Hit 0.0% —
4595 KP13_01215 Ascorbate-specific phosphotransferase enzyme IIB component ulaB AlphaFold DB model + ColabFold model
2.7.1.194
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.160 0.46 No Hit 0.0% —
4596 KP13_01041 Phosphohistidine phosphatase sixA sixA AlphaFold DB model + ColabFold model
3.1.3.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0101006Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
No map 0.160 0.26 No Hit 0.0% —
4597 KP13_00111 oxaloacetate decarboxylase AlphaFold DB model + ColabFold model
4.1.3.17
GO:0047443Catalysis of the reactions: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate, and 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate. GO:0046872Binding to a metal ion. GO:0042537The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. +25 total
No map 0.160 0.231 No Hit 0.0% —
4598 KP13_06620 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.159 0.566 No Hit 0.0% —
4599 KP13_03819 putative arsenate reductase AlphaFold DB model + ColabFold model
1.20.4.1
GO:0008794Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
No map N/A 0.159 No Hit 0.0% —
4600 KP13_03758 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.159 0.199 No Hit 0.0% —
Page of 234 · 5842 total proteins