Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4601 KP13_01877 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.159 No Hit 0.0% —
4602 KP13_00434 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.159 No Hit 0.0% —
4603 KP13_03876 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.158 0.859 No Hit 0.0% —
4604 KP13_03254 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.158 0.273 No Hit 0.0% —
4605 KP13_01613 HTH-type transcriptional regulator hexR hexR AlphaFold DB model + ColabFold model –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.158 0.617 No Hit 0.0% —
4606 KP13_01138 hypothetical protein ColabFold model – – No map N/A 0.158 No Hit 0.0% —
4607 KP13_31983 Thiosulfate sulfurtransferase AlphaFold DB model + ColabFold model –
GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+.
No map 0.157 0.696 No Hit 0.0% —
4608 KP13_31568 Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE arnE AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:1901505Enables the transfer of carbohydrate derivative from one side of a membrane to the other. +36 total
No map 0.157 0.74 No Hit 0.0% —
4609 KP13_02291 Exodeoxyribonuclease V gamma chain recC AlphaFold DB model + ColabFold model –
GO:0009338An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA. GO:0008854Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
No map 0.157 0.581 No Hit 0.0% —
4610 KP13_00617 D-tyrosyl-tRNA(Tyr) deacylase dtd AlphaFold DB model + ColabFold model
3.1.1.96 3.1.1.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051499Catalysis of the reaction: a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H+. Removal of a D-amino acid from a charged tRNA. GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. +58 total
No map 0.157 0.778 Hit 37.4% 3.65e-24
4611 KP13_05551 Periplasmic binding protein/LacI transcriptional regulator family protein Experimental + ColabFold model – – No map 0.156 0.5 No Hit 0.0% —
4612 KP13_04800 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.156 0.37 No Hit 0.0% —
4613 KP13_02946 hypothetical protein ColabFold model – – No map 0.156 0.731 No Hit 0.0% —
4614 KP13_02896 hypothetical protein ColabFold model – – No map N/A 0.156 No Hit 0.0% —
4615 KP13_02729 Endonuclease-1 endA AlphaFold DB model + ColabFold model –
GO:0004518Catalysis of the cleavage of ester linkages within nucleic acids. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.156 0.82 No Hit 0.0% —
4616 KP13_01781 D-methionine-binding lipoprotein metQ metQ AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015821The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.156 0.597 No Hit 0.0% —
4617 KP13_01500 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.156 0.154 No Hit 0.0% —
4618 KP13_01349 Bifunctional protein birA birA Experimental + ColabFold model
6.3.4.15
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). GO:0004077Catalysis of the reaction: ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H+ + N(6)-biotinyl-L-lysyl-[protein]. +36 total
No map 0.156 0.976 Hit 31.7% 4.92e-06
4619 KP13_01161 Twin-arginine leader-binding protein dmsD dmsD AlphaFold DB model + ColabFold model –
GO:0005048Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.
No map 0.156 0.346 No Hit 0.0% —
4620 KP13_01030 Flagellar regulator flk flk AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0010468Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
No map 0.156 0.481 No Hit 0.0% —
4621 KP13_00483 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.156 0.243 No Hit 0.0% —
4622 KP13_00056 2-oxo-3-deoxygalactonate kinase dgoK Experimental + ColabFold model –
GO:0008671Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+. GO:0034194The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid.
No map 0.156 0.709 No Hit 0.0% —
4623 KP13_20485 Cytochrome o ubiquinol oxidase subunit 3 cyoC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0022904A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. +47 total
No map 0.155 0.043 Hit 27.9% 1.56e-09
4624 KP13_03783 O-antigen export system ATP-binding protein rfbB rfbB AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +14 total
No map 0.155 0.881 Hit 33.5% 5.68e-26
4625 KP13_02100 hypothetical protein ColabFold model – – No map N/A 0.155 No Hit 0.0% —
Page of 234 · 5842 total proteins