Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4601 KP13_04410 hypothetical protein AlphaFold + ColabFold – – 0.296 No Hit 0.0% —
4602 KP13_04177 hypothetical protein ColabFold – – 0.296 No Hit 0.0% —
4603 KP13_03127 hypothetical protein ColabFold – – 0.296 No Hit 0.0% —
4604 KP13_01986 Molybdopterin adenylyltransferase mog AlphaFold + ColabFold
2.7.7.75
GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0061598Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.
0.296 Hit 40.0% 5.91e-18
4605 KP13_01851 sugar fermentation stimulation protein sfsA AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.296 No Hit 0.0% —
4606 KP13_00898 hypothetical protein ColabFold – – 0.296 No Hit 0.0% —
4607 KP13_00188 Formamidopyrimidine-DNA glycosylase bifunctional protein mutM AlphaFold + ColabFold
3.2.2.23 4.2.99.18
GO:0008270Binding to a zinc ion (Zn). GO:0003684Binding to damaged DNA. GO:0003906Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). +912 total
0.296 Hit 28.9% 2.44e-06
4608 KP13_05536 putative PTS family enzyme IIA/ enzyme IIBC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
0.295 No Hit 0.0% —
4609 KP13_05226 5-hydroxyisourate hydrolase hpxT Experimental + ColabFold –
GO:0006144The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. GO:0033971Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+.
0.295 No Hit 0.0% —
4610 KP13_03832 thioredoxin domain-containing protein AlphaFold + ColabFold – – 0.295 No Hit 0.0% —
4611 KP13_03504 putative extracellular solute-binding protein AlphaFold + ColabFold –
GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.295 No Hit 0.0% —
4612 KP13_02417 hypothetical protein AlphaFold + ColabFold – – 0.295 No Hit 0.0% —
4613 KP13_01517 Cold-shock DNA-binding domain-containing protein AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid.
0.295 No Hit 0.0% —
4614 KP13_05627 hypothetical protein AlphaFold + ColabFold – – 0.294 No Hit 0.0% —
4615 KP13_04645 Fe(3+) dicitrate transport ATP-binding protein fecE fecE AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.294 Hit 36.2% 6.90e-07
4616 KP13_04628 Cysteine desulfuration protein sufE sufE AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0006790The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.294 No Hit 0.0% —
4617 KP13_04520 2-halobenzoate 1,2-dioxygenase large subunit cbdA AlphaFold + ColabFold –
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0005506Binding to an iron (Fe) ion. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. +14 total
0.294 No Hit 0.0% —
4618 KP13_04318 hypothetical protein AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.294 No Hit 0.0% —
4619 KP13_03681 putative lipoprotein AlphaFold + ColabFold – – 0.294 No Hit 0.0% —
4620 KP13_03330 putative Filamentous hemagglutinin AlphaFold + ColabFold – – 0.294 No Hit 0.0% —
4621 KP13_02725 hypothetical protein AlphaFold + ColabFold – – 0.294 No Hit 0.0% —
4622 KP13_02145 hypothetical protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.294 No Hit 0.0% —
4623 KP13_02122 Amino acid ABC superfamily ATP binding cassette transporter, binding protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015276Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. +25 total
0.294 Hit 42.5% 3.55e-06
4624 KP13_00692 33 kDa chaperonin hslO AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051082Binding to an unfolded protein. GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +25 total
0.294 No Hit 0.0% —
4625 KP13_00272 Dipeptide transport ATP-binding protein dppF dppF AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.294 Hit 39.1% 6.48e-08
Page of 234 · 5842 total proteins