Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4551 KP13_32399 hypothetical protein ColabFold model – – No map N/A 0.169 No Hit 0.0% —
4552 KP13_05363 HTH-type transcriptional regulator ttuA AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
No map 0.169 0.663 No Hit 0.0% —
4553 KP13_04000 Protease degS degS AlphaFold DB model + ColabFold model
3.4.21.107
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +36 total
No map 0.169 0.322 Hit 36.9% 1.45e-18
4554 KP13_00217 Putative L-lactate dehydrogenase operon regulatory protein lldR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.169 0.138 No Hit 0.0% —
4555 KP13_04650 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.168 No Hit 0.0% —
4556 KP13_04341 Hcp family type VI secretion system protein AlphaFold DB model + ColabFold model – – No map 0.168 0.2 No Hit 0.0% —
4557 KP13_03934 Transcriptional regulator, LysR family ColabFold model – – No map 0.168 0.381 No Hit 0.0% —
4558 KP13_01713 putative HAD-superfamily hydrolase AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
No map 0.168 0.344 Hit 24.7% 2.06e-11
4559 KP13_01431 Alpha-D-phosphohexomutase N-terminal domain-containing protein AlphaFold DB model + ColabFold model
5.4.2.10
GO:0016868Catalysis of the transfer of a phosphate group from one position to another within a single molecule. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
No map 0.168 0.424 No Hit 0.0% —
4560 KP13_05645 hypothetical protein ColabFold model – – No map 0.167 0.503 No Hit 0.0% —
4561 KP13_02214 Arsenate reductase arsC AlphaFold DB model + ColabFold model
1.20.4.1
GO:0008794Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. GO:0046685Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
No map N/A 0.167 No Hit 0.0% —
4562 KP13_02088 Phosphate starvation-inducible protein psiF psiF AlphaFold DB model + ColabFold model – – No map 0.167 0.267 No Hit 0.0% —
4563 KP13_01001 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.167 0.12 No Hit 0.0% —
4564 KP13_00896 PBSX phage terminase small subunit AlphaFold DB model + ColabFold model –
GO:0051276A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
No map N/A 0.167 No Hit 0.0% —
4565 KP13_16560 S-ribosylhomocysteine lyase luxS AlphaFold DB model + ColabFold model
4.4.1.21
GO:0043768Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine. GO:0005506Binding to an iron (Fe) ion. GO:0046872Binding to a metal ion. +14 total
No map 0.166 0.563 No Hit 0.0% —
4566 KP13_04410 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.166 0.296 No Hit 0.0% —
4567 KP13_02323 hypothetical protein ColabFold model – – No map 0.166 0.748 No Hit 0.0% —
4568 KP13_02290 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map N/A 0.166 No Hit 0.0% —
4569 KP13_01267 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.166 No Hit 0.0% —
4570 KP13_00717 Peptidyl-prolyl cis-trans isomerase A ppiA AlphaFold DB model + ColabFold model
5.2.1.8
GO:0000413The modification of a protein by cis-trans isomerization of a proline residue. GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +14 total
No map 0.166 0.631 Hit 44.2% 2.78e-09
4571 KP13_03825 Lipoprotein 34 nlpB AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0051205The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.
No map 0.165 0.558 No Hit 0.0% —
4572 KP13_02526 Phenolic acid decarboxylase subunit B AlphaFold DB model + ColabFold model
2.5.1.129
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0106141Catalysis of the reaction: dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2. +14 total
No map 0.165 0.547 No Hit 0.0% —
4573 KP13_01655 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase pgsA AlphaFold DB model + ColabFold model
2.7.8.5
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016780Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). GO:0008444Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+. +36 total
No map 0.165 0.939 Hit 41.3% 1.90e-08
4574 KP13_01137 CinA family protein Experimental + ColabFold model – – No map 0.165 0.781 No Hit 0.0% —
4575 KP13_00185 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No map 0.165 0.7 No Hit 0.0% —
Page of 234 · 5842 total proteins