Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4626 KP13_01869 putative isomerase AlphaFold DB model + ColabFold model
5.2.1.8
GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
No map 0.155 0.298 No Hit 0.0% —
4627 KP13_01494 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.155 0.177 No Hit 0.0% —
4628 KP13_32094 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.154 0.906 No Hit 0.0% —
4629 KP13_02119 branched-chain amino acid transport ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +14 total
No map 0.154 0.67 Hit 29.4% 7.56e-08
4630 KP13_04043 Antitermination protein ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map N/A 0.153 No Hit 0.0% —
4631 KP13_02654 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.153 0.805 No Hit 0.0% —
4632 KP13_02122 Amino acid ABC superfamily ATP binding cassette transporter, binding protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015276Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. +25 total
No map 0.153 0.294 Hit 42.5% 3.55e-06
4633 KP13_01746 Protoporphyrinogen oxidase hemG AlphaFold DB model + ColabFold model
1.3.5.3
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0006783The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. +47 total
No map 0.153 0.918 No Hit 0.0% —
4634 KP13_01460 Protein sirB1 sirB1 AlphaFold DB model + ColabFold model – – No map 0.153 0.377 No Hit 0.0% —
4635 KP13_01448 Chorismate mutase aroH AlphaFold DB model + ColabFold model
5.4.99.5
GO:0046417The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid. GO:0004106Catalysis of the reaction: chorismate = prephenate. GO:0009697The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid.
No map 0.153 0.525 No Hit 0.0% —
4636 KP13_04475 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.152 No Hit 0.0% —
4637 KP13_02751 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.152 No Hit 0.0% —
4638 KP13_02545 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.152 No Hit 0.0% —
4639 KP13_01275 Antitoxin RelB relB AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template.
No map N/A 0.152 No Hit 0.0% —
4640 KP13_00212 Protein-export protein secB secB AlphaFold DB model + ColabFold model –
GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0051082Binding to an unfolded protein. GO:0051262The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. +25 total
No map 0.152 0.834 No Hit 0.0% —
4641 KP13_12802 L-serine dehydratase 1 sdaA AlphaFold DB model + ColabFold model
4.3.1.17
GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003941Catalysis of the reaction: L-serine = pyruvate + NH4+. +25 total
No map 0.151 0.365 No Hit 0.0% —
4642 KP13_05407 putative ABC transporter ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.151 0.217 Hit 42.9% 3.56e-06
4643 KP13_05371 Outer membrane protein W ompW AlphaFold DB model + ColabFold model –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.151 0.998 No Hit 0.0% —
4644 KP13_05152 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.151 No Hit 0.0% —
4645 KP13_04511 Respiratory nitrate reductase 2 beta chain narY AlphaFold DB model + ColabFold model
1.7.5.1
GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0042126The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid. GO:0008940Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. +811 total
No map 0.151 0.613 No Hit 0.0% —
4646 KP13_04193 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.151 0.149 No Hit 0.0% —
4647 KP13_01454 Replication protein repA repA AlphaFold DB model + ColabFold model –
GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0006270The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
No map 0.151 0.604 No Hit 0.0% —
4648 KP13_04819 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.15 No Hit 0.0% —
4649 KP13_04815 hypothetical protein ColabFold model – – No map 0.150 0.663 No Hit 0.0% —
4650 KP13_01653 nucleic acid binding domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.150 0.71 No Hit 0.0% —
Page of 234 · 5842 total proteins