Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4626 KP13_32238 Ethanolamine ammonia-lyase heavy chain eutB AlphaFold + ColabFold
4.3.1.7
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0008851Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
0.293 No Hit 0.0% —
4627 KP13_04253 Putrescine transport ATP-binding protein potG potG AlphaFold + ColabFold
7.6.2.11
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015417Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in). +58 total
0.293 Hit 34.7% 4.90e-24
4628 KP13_04064 Glyoxalase/bleomycin resistance protein/dioxygenase AlphaFold + ColabFold –
GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.
0.293 No Hit 0.0% —
4629 KP13_02348 Glycine cleavage system transcriptional activator gcvA AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.293 No Hit 0.0% —
4630 KP13_01816 Carbohydrate diacid regulator cdaR AlphaFold + ColabFold – – 0.293 No Hit 0.0% —
4631 KP13_01035 hypothetical protein AlphaFold + ColabFold – – 0.293 No Hit 0.0% —
4632 KP13_00587 Superoxide dismutase Mn sodA AlphaFold + ColabFold
1.15.1.1
GO:0004784Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. GO:0006801The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. GO:0046872Binding to a metal ion. +25 total
0.293 Hit 54.3% 2.20e-11
4633 KP13_31998 Glutathione S-transferase GstB gstB AlphaFold + ColabFold
2.5.1.18
GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+.
0.292 Hit 26.2% 5.20e-09
4634 KP13_05582 thermonuclease family protein AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.292 No Hit 0.0% —
4635 KP13_04838 Very short patch repair protein vsr AlphaFold + ColabFold
3.1.-.-
GO:0006298A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.292 No Hit 0.0% —
4636 KP13_02860 Autoinducer 2 import ATP-binding protein LsrA lsrA AlphaFold + ColabFold
7.6.2.13
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.292 Hit 35.7% 3.51e-10
4637 KP13_02730 Ribosomal RNA small subunit methyltransferase E rsmE AlphaFold + ColabFold
2.1.1.193
GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.292 No Hit 0.0% —
4638 KP13_00550 Inner membrane protein AlphaFold + ColabFold – – 0.292 No Hit 0.0% —
4639 KP13_04682 hypothetical protein AlphaFold + ColabFold –
GO:0004521Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.
0.291 No Hit 0.0% —
4640 KP13_04388 hypothetical protein AlphaFold + ColabFold – – 0.291 No Hit 0.0% —
4641 KP13_03767 ATP phosphoribosyltransferase hisG AlphaFold + ColabFold
2.4.2.17
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0003879Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. +25 total
0.29 No Hit 0.0% —
4642 KP13_03290 Allophanate hydrolase subunit 1 domain-containing protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.29 No Hit 0.0% —
4643 KP13_03064 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.29 No Hit 0.0% —
4644 KP13_02476 PTS system protein, mannose/fructose/sorbose family, IIA component Experimental + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
0.29 No Hit 0.0% —
4645 KP13_02141 Glutamate 5-kinase proB AlphaFold + ColabFold
2.7.2.11
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006561OBSOLETE. The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +58 total
0.29 Hit 33.4% 3.33e-32
4646 KP13_01616 putative metalloprotease AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +14 total
0.29 No Hit 0.0% —
4647 KP13_01271 putative selenocysteine synthase AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004125Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate.
0.29 No Hit 0.0% —
4648 KP13_00868 Exodeoxyribonuclease 7 large subunit xseA AlphaFold + ColabFold
3.1.11.6
GO:0008855Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides. GO:0003676Binding to a nucleic acid. GO:0006308The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. +25 total
0.29 No Hit 0.0% —
4649 KP13_00088 transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.29 No Hit 0.0% —
4650 KP13_32040 hypothetical protein AlphaFold + ColabFold – – 0.289 No Hit 0.0% —
Page of 234 · 5842 total proteins